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Adv Sci (Weinh) June 2023 PMID 37066758

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects.

Hai-Jun Liu, Wei Chen, Gongwei Wu, Jun Zhou, Chuang Liu, Zhongmin Tang, Xiangang Huang, Jingjing Gao, Yufen Xiao, Na Kong, Nitin Joshi, Yihai Cao, Reza Abdi, Wei Tao

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Mentions

7
Peak: 6 in Apr 2023
across 2 sources since Apr 2023

Extended reach

6,763
potential audience

Total likes

18

Video views

15

Mentions per month

Apr 2023 – Sep 2023

Where it's discussed

  • X / Twitter6 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions emphasize the potential of NanoPROTACs to revolutionize cancer therapy by showcasing them as 'promising' and 'innovative,' with users discussing molecular mechanisms such as glutathione scavenging and improved targeting, which underscores their deep engagement and recognition of high impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the innovative nanoparticle-based delivery system for targeted protein degradation, with some explicitly calling it a 'game changer' in cancer therapy.

InterestHigh interest

Posts demonstrate high curiosity, with frequent mentions of how the approach improves efficiency and safety, indicating strong interest.

EngagementModerate engagement

Comments include references to specific mechanisms like glutathione scavenging and implications for disease treatment, reflecting active engagement.

ImpactHigh impact

The discussions highlight potential for significant advances in treatment modalities, portraying the research as impactful for future therapies.

Abstract in brief

  • The article discusses NanoPROTACs, a new method that uses nanoparticles to deliver PROTACs, which are molecules that target and degrade harmful proteins inside cells, especially in cancer therapy.
  • NanoPROTACs improve the delivery and effectiveness of PROTACs by encapsulating them in special polymers that respond to the cellular environment, leading to better degradation of cancer-related proteins like BRD4 and reduction of oncogenes such as cMyc.
  • This nanoengineered approach shows promising results with low doses, strong anti-tumor effects, and good safety in animal studies, highlighting its potential to treat various diseases by removing disease-causing proteins.]
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Top posts

Most liked on X and Bluesky
Guillaume Laconde
@Glaconde34 · X

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects https://t.co/VYlpeOcNiC

Apr 17, 2023 · 18 likes · 3 shares · 4,864 followers View post →
Emma Chan , PhD
@binggo203 · X

RT @Glaconde34: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effe…

Apr 17, 2023 · 3 shares · 960 followers View post →
Protein-Degraders
@ProtDegraders · X

RT @Dr_JoelCB: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effec…

Apr 17, 2023 · 1 share · 490 followers View post →
Joel C-B
@Dr_JoelCB · X

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects https://t.co/L4R26nK9zO

Apr 17, 2023 · 1 share · 165 followers View post →
Allan
@Allan_Qiao · X

RT @Glaconde34: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effe…

Apr 17, 2023 · 3 shares · 158 followers View post →
Molly20256
@Molly20186 · X

RT @Glaconde34: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effe…

Apr 17, 2023 · 3 shares · 83 followers View post →

All mentions

Emma Chan , PhD
@binggo203 · X

RT @Glaconde34: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effe…

Apr 17, 2023 · 3 shares · 960 followers View post →
Allan
@Allan_Qiao · X

RT @Glaconde34: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effe…

Apr 17, 2023 · 3 shares · 158 followers View post →
Molly20256
@Molly20186 · X

RT @Glaconde34: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effe…

Apr 17, 2023 · 3 shares · 83 followers View post →
Protein-Degraders
@ProtDegraders · X

RT @Dr_JoelCB: Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effec…

Apr 17, 2023 · 1 share · 490 followers View post →
Guillaume Laconde
@Glaconde34 · X

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects https://t.co/VYlpeOcNiC

Apr 17, 2023 · 18 likes · 3 shares · 4,864 followers View post →
Joel C-B
@Dr_JoelCB · X

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects https://t.co/L4R26nK9zO

Apr 17, 2023 · 1 share · 165 followers View post →