April 2023 PMID 37068229

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice.

Yi-Zhou Quan, Wei Wei, Volkan Ergin, Arun Prabhu Rameshbabu, Mingqian Huang, Chunjie Tian, Srinivas Vinod Saladi, Artur A Indzhykulian, Zheng-Yi Chen

Mentions

87
Peak: 29 in Apr 2023
across 5 sources since Apr 2023

Extended reach

2,168,058
potential audience

Total likes

11,912

Video views

831,740

Mentions per month

Apr 2023 – Feb 2024

Where it's discussed

  • X / Twitter41 posts
  • News32 articles
  • Reddit8 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

Several posts emphasize the groundbreaking nature of the research, using words like 'potential,' 'hope,' and 'game changer,' which reflect high interest and perceived importance. The tone varies from enthusiastic support to scientific acknowledgment, indicating that the audience recognizes the study's potential impact and engages deeply with both its methods and implications.

AgreementStrong agreement

Most discussions express strong support and optimism for the research, highlighting its potential to revolutionize hearing loss treatment.

InterestHigh interest

The discussions demonstrate high curiosity, with many comments emphasizing new scientific breakthroughs and potential cures.

EngagementHigh engagement

Posts frequently reference specific scientific aspects, such as molecular cocktails and cellular pathways, showing deep engagement with the research details.

ImpactHigh impact

Many discussions underscore the significant implications for people suffering from hearing loss, suggesting the work could lead to transformative therapies.

Abstract in brief

  • The study explores a new method to regenerate cochlear hair cell-like cells in adult mice using drug-like molecules that activate specific cellular pathways, potentially offering a solution for irreversible hearing loss.
  • Researchers used single-cell RNA sequencing to show that activating MYCNICD, along with pathways such as Wnt and cAMP, can rejuvenate supporting cells and promote hair cell-like regeneration, even in mature, non-transgenic mice.
  • A cocktail of small molecules and small interfering RNAs was developed to replace genetic modifications, successfully reprogramming mature supporting cells into hair cell-like cells both in vitro and in living mice, paving the way for potential hearing restoration therapies.]

Top posts

Most liked on X and Bluesky
Eric Klein
@EricKLein_ · X

Le chercheur Zheng-Yi Chen et son équipe de la Harvard Medical School ont mis au point une thérapie génique permettant la régénération des cellules ciliées. Un espoir pour tous ceux souffrant de surdité neurosensorielle https://t.co/YcAZ3vGPYi

Apr 28, 2023 · 10 likes · 3 shares · 22,174 followers View post →
Medical Xpress
@medical_xpress · X

Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1gzUs0PTS2 https://t.co/QrDuTTmiwx

Apr 18, 2023 · 7 likes · 8 shares · 173,000 followers View post →
Artur Indzhykulian
@IndArtur · X

Yay! Congrats to the Chen lab for getting this collaborative work published! https://t.co/eDMHBw0oQa

Apr 17, 2023 · 6 likes · 3 shares · 81 followers View post →
Agingdoc
@agingdoc1 · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice https://t.co/f5PhuTNLp5 @PNASNews https://t.co/NDOvqvage6

May 18, 2023 · 3 likes · 2 shares · 41,342 followers View post →
fj
@gecko39 · X

https://t.co/qBP2jc4CP6

Apr 28, 2023 · 1 like · 2,137 followers View post →
fj
@gecko39 · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice | Proceedings of the National Academy of Sciences https://t.co/qBP2jc4CP6

Apr 28, 2023 · 1 like · 1 share · 2,137 followers View post →

All mentions

Ramin Nayersina
@biotechinvent · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice Yi-Zhou Quan et al. https://t.co/WhmQaGX2qE PNAS April 17, 2023 120 (17) e2215253120

Feb 28, 2024 · 1 like · 4 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @agingdoc1: Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice https://t.co/f5Ph…

May 18, 2023 · 2 shares · 6,644 followers View post →
Catalina Vasilescu, PhD
@_CVasilescu · X

RT @agingdoc1: Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice https://t.co/f5Ph…

May 18, 2023 · 2 shares · 1,048 followers View post →
Agingdoc
@agingdoc1 · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice https://t.co/f5PhuTNLp5 @PNASNews https://t.co/NDOvqvage6

May 18, 2023 · 3 likes · 2 shares · 41,342 followers View post →
Orlando_uy
@Orlando_uy · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice | Proceedings of the National Academy of Sciences https://t.co/XVw6OjpwJJ

May 18, 2023 · 690 followers View post →
Cathy Carlin
@CathyC4138 · X

@elonmusk Agreed. Also, money for hearing aids = great. Better hearing aids = amazing. Money for a CURE for hearing loss (and tinnitus) = what is really needed. https://t.co/2s1tCPBn73 https://t.co/l9U8wHls5N

May 8, 2023 · 1 followers View post →
John Topham
@John_P_Topham · X

Potential for reversal of hearing loss. https://t.co/appZtO12bO

May 4, 2023 · 628 followers View post →
localhostscience
@localhostsci · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice

May 3, 2023 · 34 followers View post →
Ken Gusler
@kgusler · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice - https://t.co/dG54yQ8So4

May 3, 2023 · 20,037 followers View post →
Mariano
@etmaroo · X

Que linda que es la ciencia https://t.co/3Vr6Xrjjjm

May 3, 2023 · 282 followers View post →
J₳zzwhistlΣ
@jazzwhistle · X

Princeton University researchers may have found a way to repair hearing loss by regrowing the sensory cells in the inner ear

May 3, 2023 · 894 followers View post →
Helene Keller-Lind
@keller_lind · X

RT @EricKLein_: Le chercheur Zheng-Yi Chen et son équipe de la Harvard Medical School ont mis au point une thérapie génique permettant la r…

May 1, 2023 · 3 shares · 4,332 followers View post →
אוליביה אוליביוש
@olivia220 · X

RT @EricKLein_: Le chercheur Zheng-Yi Chen et son équipe de la Harvard Medical School ont mis au point une thérapie génique permettant la r…

Apr 28, 2023 · 3 shares · 6,015 followers View post →
Dirk Diggler
@RoussetDauge · X

RT @EricKLein_: Le chercheur Zheng-Yi Chen et son équipe de la Harvard Medical School ont mis au point une thérapie génique permettant la r…

Apr 28, 2023 · 3 shares · 598 followers View post →
Eric Klein
@EricKLein_ · X

Le chercheur Zheng-Yi Chen et son équipe de la Harvard Medical School ont mis au point une thérapie génique permettant la régénération des cellules ciliées. Un espoir pour tous ceux souffrant de surdité neurosensorielle https://t.co/YcAZ3vGPYi

Apr 28, 2023 · 10 likes · 3 shares · 22,174 followers View post →
fj
@gecko39 · X

RT @gecko39: Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice 17APR2023 https://…

Apr 28, 2023 · 1 share · 2,137 followers View post →
fj
@gecko39 · X

RT @gecko39: Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice | Proceedings of the…

Apr 28, 2023 · 1 share · 2,137 followers View post →
fj
@gecko39 · X

https://t.co/qBP2jc4CP6

Apr 28, 2023 · 1 like · 2,137 followers View post →
fj
@gecko39 · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice | Proceedings of the National Academy of Sciences https://t.co/qBP2jc4CP6

Apr 28, 2023 · 1 like · 1 share · 2,137 followers View post →
fj
@gecko39 · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice 17APR2023 https://t.co/qBP2jc4CP6 Proceedings of the National Academy of Sciences

Apr 28, 2023 · 1 like · 1 share · 2,137 followers View post →
cagsei
@cagsei · X

Bilim insanları iç kulaktaki işitmeyi mümkün kılan tüy hücrelerini başarılı bir şekilde yenileyebileceğini söyledikleri moleküllerden oluşan yeni bir ilaç kokteyli geliştirdiklerini ve bunun işitme kaybı için çığır açabilecek bir tedavi olduğunu söylüyor. https://t.co/xsokNbv5P3 https://t.co/bKJh64NkHM

Apr 25, 2023 · 56 followers View post →
Bipartisan Alliance
@jorgemata · X

https://t.co/LHljQa1PlC

Apr 24, 2023 · 187 followers View post →
Mariam Sherzad
@MariamSherzad · X

#Harvard being Harvard.. 1st #longevity, now they may have discovered a drug cocktail of molecules that can successfully #regenerate the (hair) #cells in the inner ear that enable hearing. Also 9/9 of these #scientists are Asian or Eastern European

Apr 24, 2023 · 1 like · 161 followers View post →
Wnt publications
@WntPublications · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice: Strategies to overcome irreversible cochlear hair cell (HC) damage and loss in mammals are of vital importance to hearing recovery in patients with… https://t.co/ieIsPP0DJZ

Apr 23, 2023 · 457 followers View post →
Azalush “森あざらし”
@align_centre · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice | PNAS (April 17, 2023) https://t.co/imtZkohXBD

Apr 22, 2023 · 2,317 followers View post →
CD BioSciences
@CDBioSciences · X

The researchers successfully regenerated cochlear hair cell-like cells in adult mice using a drug-like cocktail of molecules. https://t.co/U7DVaCibaJ

Apr 21, 2023 · 32 followers View post →
Emil Awad
@emilawad · X

#Hope for those suffering #HearingLoss this findings will eventually find their way to humans. Thank you @harvardmed https://t.co/eeK69iiJag

Apr 21, 2023 · 101 followers View post →
flosz
@floszcrxl · X

Drug-Like Cocktail Used by Researchers to Regenerate Hair Cells for Hearing Loss in Preclinical Study https://t.co/shW9O91Tho Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice https://t.co/CU7RwNpodZ https://t.co/l2cUnyxCzf

Apr 20, 2023 · 691 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice | Proceedings of the National Academy of Sciences https://t.co/Dg8mpvIOGl

Apr 18, 2023 · 2,569 followers View post →
Sumana Ghosh
@sumanaghosh85 · X

RT @IndArtur: Yay! Congrats to the Chen lab for getting this collaborative work published! https://t.co/eDMHBw0oQa

Apr 18, 2023 · 3 shares · 176 followers View post →
serrgv
@serrgv · X

RT @medical_xpress: Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1…

Apr 18, 2023 · 8 shares · 148 followers View post →
Manu Gupta
@guptam108 · X

RT @medical_xpress: Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1…

Apr 18, 2023 · 8 shares · 1,088 followers View post →
Dr. Samadov Aabdić
@samadovaabditch · X

RT @medical_xpress: Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1…

Apr 18, 2023 · 8 shares · 3,377 followers View post →
Religion and the world
@isarahyh · X

RT @medical_xpress: Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1…

Apr 18, 2023 · 8 shares · 996 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1…

Apr 18, 2023 · 8 shares · 7,104 followers View post →
Science X
@sciencex_com · X

RT @medical_xpress: Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1…

Apr 18, 2023 · 8 shares · 3,528 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1…

Apr 18, 2023 · 8 shares · 1,023,875 followers View post →
Medical Xpress
@medical_xpress · X

Scientists use drug-like cocktail to regenerate #haircells in preclinical study @masseyeandear @PNASNews https://t.co/1gzUs0PTS2 https://t.co/QrDuTTmiwx

Apr 18, 2023 · 7 likes · 8 shares · 173,000 followers View post →
Sora
@Sora_3690 · X

RT @IndArtur: Yay! Congrats to the Chen lab for getting this collaborative work published! https://t.co/eDMHBw0oQa

Apr 17, 2023 · 3 shares · 5 followers View post →
Pedro De-la-Torre, PhD.
@pedrodelatorrem · X

RT @IndArtur: Yay! Congrats to the Chen lab for getting this collaborative work published! https://t.co/eDMHBw0oQa

Apr 17, 2023 · 3 shares · 766 followers View post →
Artur Indzhykulian
@IndArtur · X

Yay! Congrats to the Chen lab for getting this collaborative work published! https://t.co/eDMHBw0oQa

Apr 17, 2023 · 6 likes · 3 shares · 81 followers View post →