Adv Sci (Weinh) June 2023 PMID 37072673

Systemic Tumor Suppression via Macrophage-Driven Automated Homing of Metal-Phenolic-Gated Nanosponges for Metastatic Melanoma.

Xue Liao, Guidong Gong, Mengyuan Dai, Zhenyu Xiang, Jiezhou Pan, Xianglian He, Jiaojiao Shang, Anna Maria Blocki, Zongmin Zhao, C Wyatt Shields, Junling Guo

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The discussions express strong enthusiasm, exemplified by phrases like 'thrilled to share' and 'exploring the supramolecular network,' highlighting excitement over the novel nanosponges. Technical references and acknowledgment of prior work suggest meaningful engagement, although the overall tone remains optimistic rather than definitive about long-term impact.

AgreementModerate agreement

Most discussions convey strong approval and enthusiasm for the research, acknowledging its innovative aspects.

InterestHigh interest

Posts show high interest, with comments celebrating progress and potential, indicating engagement with cutting-edge methods.

EngagementModerate engagement

Comments include technical references such as supramolecular networks and nanogates, reflecting active participation.

ImpactModerate impact

The discussions highlight the promising therapeutic potential and scientific significance of the publication, albeit in preliminary or conceptual terms.

Abstract in brief

The study introduces a macrophage-based drug delivery system called MAGN, which uses genetically modified macrophages with nanosponges that can target tumors effectively, especially for metastatic melanoma.
The nanosponges are engineered with iron-tannic acid gatekeepers that respond to the acidic tumor environment, controlling drug release through a mechanism studied using molecular simulations.
Experiments show that this system can deliver drugs precisely to tumors, reducing tumor growth and metastasis, making it a promising approach for treating advanced cancers with high drug-loading capabilities.]

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Macrophage-Driven Nanosponges for Tumor Suppression in Melanoma

STEM RTCL TV · Sep 19, 2023 542 views

H. Zhao

@zhao_h · X

RT @WyattShieldsIV:

Aug 22, 2023 · 5 shares · 65 followers View post →

Junling Guo

@junling_g · X

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Apr 28, 2023 · 5 shares · 135 followers View post →

Junling Guo

@junling_g · X

Apr 28, 2023 · 4 likes · 135 followers View post →

MelanomaResearchPapers

@MelanRes_papers · X

Systemic Tumor Suppression via Macrophage-Driven Automated Homing of Metal-Phenolic-Gated Nanosponges for Metastatic Melanoma https://t.co/mf2CKCxSqO

Apr 23, 2023 · 111 followers View post →

Ingentium Melanoma

@ingentium_mel · X

Systemic Tumor Suppression via Macrophage-Driven Automated Homing of Metal-Phenolic-Gated Nanosponges for Metastatic Melanoma. https://t.co/82oFxSMhxA https://t.co/U0zuvzUfFE

Apr 19, 2023 · 205 followers View post →

Amit Kumar Rajora

@drchemistrajora · X

RT @WyattShieldsIV:

Apr 19, 2023 · 5 shares · 676 followers View post →

Zongmin Zhao

@zongmin_zhao · X

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Apr 19, 2023 · 5 shares · 1,168 followers View post →

Devika S Manickam (she/her)

@manickam_lab · X

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Apr 19, 2023 · 5 shares · 999 followers View post →

Wyatt Shields

@WyattShieldsIV · X

Apr 19, 2023 · 17 likes · 5 shares · 1,106 followers View post →

Systemic Tumor Suppression via Macrophage-Driven Automated Homing of Metal-Phenolic-Gated Nanosponges for Metastatic Melanoma.

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Macrophage-Driven Nanosponges for Tumor Suppression in Melanoma