Nat Commun April 2023 PMID 37076519

Latent generative landscapes as maps of functional diversity in protein sequence space.

Cheyenne Ziegler, Jonathan Martin, Claude Sinner, Faruck Morcos

Mentions

11
Peak: 5 in Apr 2023
across 3 sources since Apr 2023

Extended reach

15,141
potential audience

Total likes

12

Video views

26

Mentions per month

Apr 2023 – Jul 2023

Where it's discussed

  • X / Twitter8 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone is positive, with comments emphasizing the innovative integration of VAEs and coevolutionary models for mapping protein diversity, including phrases like 'maps of functional diversity' and hashtags like #MachineLearning and #AI. The words and context demonstrate genuine interest and a belief that this research could have meaningful impact on protein engineering and evolutionary studies.

AgreementModerate agreement

Most discussions recognize the significance of the research, with some explicitly supporting its potential applications.

InterestHigh interest

The topic is highly engaging for those interested in bioinformatics, machine learning, and protein engineering, as reflected by the enthusiastic hashtags and positive tone.

EngagementModerate engagement

Posts mention specifics like the use of generative landscapes and integration with coevolutionary models, indicating active participation and understanding.

ImpactModerate impact

The discussions highlight the potential of this approach to advance the field, describing it as 'important' or 'innovative,' which suggests a recognition of its significance.

Abstract in brief

  • This study explores how variational autoencoders (VAEs) can be used to map and analyze the "latent landscape" of protein sequences, helping to understand their evolutionary relationships, functions, and fitness.
  • By combining VAEs with coevolutionary models like the Potts Hamiltonian, researchers can capture important features such as phylogenetic groupings and functional properties across different protein systems like Globins and ion channels.
  • The findings suggest that this integrated approach of generative modeling and coevolutionary analysis can improve protein engineering and design by revealing how sequence variations influence protein function and evolution.

Top posts

Most liked on X and Bluesky
BioDecoded
@BioDecoded · X

Latent generative landscapes as maps of functional diversity in protein sequence space | Nature Communications https://t.co/rl7qaEvAOt #Bioinformatics https://t.co/7Z4b12S376

May 2, 2023 · 10 likes · 3 shares · 8,901 followers View post →
Paul Lopez
@lopezunwired · X

Latent generative landscapes as maps of functional diversity in protein sequence space https://t.co/dj7DEwedv9 #MachineLearning #NatureJournal #AI https://t.co/F1xfw8xHaA

Apr 19, 2023 · 1 like · 2,480 followers View post →
UT Dallas Biology
@UTD_Biology · X

New publication from UTD_Biology. https://t.co/v7LzeZy7ff. Latent generative landscapes as maps of functional diversity in protein sequence space

Apr 20, 2023 · 1 like · 1,239 followers View post →
Reluctant Quant
@DrMattCrowson · X

RT Latent generative landscapes as maps of functional diversity in protein sequence space https://t.co/xWgZVvLAWG https://t.co/N1jjKZl4dp

Apr 19, 2023 · 1,259 followers View post →
J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @BioDecoded: Latent generative landscapes as maps of functional diversity in protein sequence space | Nature Communications https://t.co…

May 2, 2023 · 3 shares · 705 followers View post →
Protein Engineering and Directed Evolution Papers
@and_protein · X

Latent generative landscapes as maps of functional diversity in protein sequence space https://t.co/iCy4NqWt7g

Apr 21, 2023 · 236 followers View post →

All mentions

J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @BioDecoded: Latent generative landscapes as maps of functional diversity in protein sequence space | Nature Communications https://t.co…

May 2, 2023 · 3 shares · 705 followers View post →
Bodhi Dharma
@dharma92biol · X

RT @BioDecoded: Latent generative landscapes as maps of functional diversity in protein sequence space | Nature Communications https://t.co…

May 2, 2023 · 3 shares · 165 followers View post →
BioDecoded
@BioDecoded · X

Latent generative landscapes as maps of functional diversity in protein sequence space | Nature Communications https://t.co/rl7qaEvAOt #Bioinformatics https://t.co/7Z4b12S376

May 2, 2023 · 10 likes · 3 shares · 8,901 followers View post →
Protein Engineering and Directed Evolution Papers
@and_protein · X

Latent generative landscapes as maps of functional diversity in protein sequence space https://t.co/iCy4NqWt7g

Apr 21, 2023 · 236 followers View post →
UT Dallas Biology
@UTD_Biology · X

New publication from UTD_Biology. https://t.co/v7LzeZy7ff. Latent generative landscapes as maps of functional diversity in protein sequence space

Apr 20, 2023 · 1 like · 1,239 followers View post →
DTHSTR
@CDADeathStar · X

Latent generative landscapes as maps of functional diversity in protein sequence space null https://t.co/D8GkEeM2Nw #DTHSTR

Apr 19, 2023 · 113 followers View post →
Paul Lopez
@lopezunwired · X

Latent generative landscapes as maps of functional diversity in protein sequence space https://t.co/dj7DEwedv9 #MachineLearning #NatureJournal #AI https://t.co/F1xfw8xHaA

Apr 19, 2023 · 1 like · 2,480 followers View post →
Reluctant Quant
@DrMattCrowson · X

RT Latent generative landscapes as maps of functional diversity in protein sequence space https://t.co/xWgZVvLAWG https://t.co/N1jjKZl4dp

Apr 19, 2023 · 1,259 followers View post →