PLoS Genet April 2023 PMID 37079639

Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption.

Rachael Thomas, Claire A Wiley, Emma L Droste, James Robertson, Brant A Inman, Matthew Breen

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Peak: 7 in Apr 2023

across 3 sources since Apr 2023

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Apr 2023 – Sep 2023

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What people are saying

Several comments highlight the discovery of short in-frame deletions in BRAF and MAP2K1 as critical to understanding molecular mechanisms in canine urothelial carcinomas, with expressions like 'new genetic culprit' emphasizing their significance. The tone and context reflect a focus on technological advances and clinical relevance, demonstrating strong interest and engagement in the research's implications.

AgreementModerate agreement

Most discussions acknowledge the significance of identifying new genetic factors in canine bladder cancers, showing general support for the findings.

InterestHigh interest

Posts demonstrate high curiosity about the genetic mechanisms and implications, reflecting strong scientific interest.

EngagementHigh engagement

The discussions include specific references to the study details and potential applications, indicating active engagement.

ImpactModerate impact

The conversations suggest that these findings could influence diagnostic approaches and cross-species cancer research, hinting at meaningful impact.

Abstract in brief

Whole exome sequencing of canine urothelial carcinomas (UC) without the BRAF V595E mutation revealed that nearly half of these cases have short inframe deletions in BRAF or MAP2K1 genes, which could activate the MAPK pathway similarly to the mutated cases.
These findings highlight alternative molecular mechanisms driving UC in dogs and may influence targeted therapy options, especially for cases lacking the common BRAF V595E mutation.
A cost-effective genotyping test was developed to detect these deletions, providing a useful tool for diagnostics and offering insights into cross-species cancer research related to MAPK pathway alterations.

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Alternative Mechanisms in Canine Urothelial Carcinoma Revealed by Exome Sequencing

Whole exome sequencing of canine urothelial carcinomas without BRAF V595E mutation revealed short in-frame deletions in BRAF and MAP2K1, suggesting alternative mechanisms for MAPK pathway disruption and potential…

Social RTCL TV · Sep 6, 2023 218 views

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