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Adv Sci (Weinh) June 2023 PMID 37085663

In Situ Nitric Oxide Gas Nanogenerator Reprograms Glioma Immunosuppressive Microenvironment.

Yang Liu, Lin Cui, Xiao Wang, Weiling Miao, Yongxu Ju, Tiandong Chen, Huiting Xu, Ning Gu, Fang Yang

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Mentions

5
Peak: 1 in Apr 2023
across 3 sources since Apr 2023

Extended reach

5,362
potential audience

Total likes

8

Video views

21

Mentions per month

Apr 2023 – Dec 2024

Where it's discussed

  • News3 articles
  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions highlight the innovative use of nitric oxide to 'reprogram' tumor environments, with posts asking if this could treat 'cold' tumors and noting the significance of targeting the immunosuppressive microenvironment. The tone reflects a mix of curiosity and cautious optimism, exemplified by phrases like 'could be a breakthrough' and 'interesting approach,' which demonstrate both engagement and recognition of potential impact.

AgreementModerate agreement

Most discussions acknowledge the innovative potential of using nitric oxide gas to target glioma tumors, indicating general support.

InterestHigh interest

Posts show high curiosity about the treatment's applications, especially regarding 'cold' tumors and reprogramming the immune environment.

EngagementModerate engagement

Comments include questions and speculation about the methods and implications, reflecting moderate participation.

ImpactModerate impact

While the potential benefits are recognized, many consider it early-stage research with uncertain immediate impact.

Abstract in brief

  • The study describes a new type of nanoliposome that delivers both chemotherapy (temozolomide) and nitric oxide (NO) prodrug to glioma tumors, targeting their immunosuppressive environment.
  • The nanoliposomes are designed to quickly target tumor cells, escape lysosomes, and release their drugs in a controlled manner, helping to overcome chemoresistance and boost tumor immunogenicity.
  • Generating NO gas reprograms the tumor’s immune environment, reducing resistance to treatment and activating immune responses, making this approach promising for treating immunosuppressive tumors.]
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Top posts

Most liked on X and Bluesky
Extracellular Matrix News
@ExtracellMatrix · X

Could nitric oxide gas be used to treat "cold" tumors? ❄️ This recent paper explores how in situ nitric oxide gas nanogenerator reprogramed the glioma immunosuppressive #microenvironment: https://t.co/BMeff9dMyC https://t.co/Y5POidGMzK

Apr 25, 2023 · 8 likes · 5,311 followers View post →

All mentions

Extracellular Matrix News
@ExtracellMatrix · X

Could nitric oxide gas be used to treat "cold" tumors? ❄️ This recent paper explores how in situ nitric oxide gas nanogenerator reprogramed the glioma immunosuppressive #microenvironment: https://t.co/BMeff9dMyC https://t.co/Y5POidGMzK

Apr 25, 2023 · 8 likes · 5,311 followers View post →
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