Genome Biol April 2023 PMID 37085823

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets.

Gerard A Bouland, Ahmed Mahfouz, Marcel J T Reinders

Mentions

38
Peak: 33 in Apr 2023
across 2 sources since Apr 2023

Extended reach

72,601
potential audience

Total likes

111

Video views

18

Mentions per month

Apr 2023 – Jul 2023

Where it's discussed

  • X / Twitter37 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions around the article reveal a focus on both the challenges posed by larger, sparser datasets and the innovative solutions proposed, such as binary data analysis. For instance, terms like 'representation and modelling' and phrases like 'little differences to counts' illustrate that posters are engaging with specific methodological aspects, indicating both curiosity and recognition of the work's potential impact.

AgreementModerate agreement

Most discussions express alignment with the publication’s perspective, highlighting both the challenges (like increased sparsity) and the potential solutions such as binary data representation.

InterestHigh interest

Posts convey high curiosity, as seen in phrases like 'super excited' and 'check our recent piece,' indicating genuine interest in the topic and its implications.

EngagementModerate engagement

Participants engage by referencing specific concepts like 'binary representation' and 'large-scale studies,' demonstrating a moderate depth of understanding and discussion around methods and opportunities.

ImpactModerate impact

The discussions suggest that the publication is perceived as meaningful, as multiple posts highlight how the research could influence advanced data analysis approaches in bioinformatics.

Abstract in brief

  • As the number of cells in single-cell RNA sequencing (scRNAseq) datasets increases, the data becomes sparser with more zero counts, but converting gene expression data to a binary (present/absent) format produces similar results to traditional count-based methods.
  • Using binary representation allows researchers to analyze up to 50 times more cells with the same computational resources, making large-scale studies more feasible.
  • Developing specialized tools for binary (bit-aware) analysis of scRNAseq data could improve the detection of biological differences and heterogeneity at a more detailed level.]

Top posts

Most liked on X and Bluesky
Ahmed Mahfouz
@ahmedElkoussy · X

If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGerard on binary representation. https://t.co/Cireu72wWR We show that many common analysis steps can be done on binarized data with little differences to counts

Apr 24, 2023 · 62 likes · 14 shares · 1,486 followers View post →
BioDecoded
@BioDecoded · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets | Genome Biology https://t.co/s1IvR0Xiol #Bioinformatics https://t.co/7i62LoS7z5

May 2, 2023 · 14 likes · 1 share · 8,901 followers View post →
antisense.
@razoralign · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGNgGyEtWo

Apr 21, 2023 · 12 likes · 6 shares · 15,928 followers View post →
Javier Santoyo
@jsantoyo · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @GenomeBiology https://t.co/MniUvasB71

Apr 29, 2023 · 11 likes · 8 shares · 6,103 followers View post →
Gerard-Bouland
@BoulandGerard · X

Super excited to share our latest work online! In this short report in @GenomeBiology we discuss the consequences and opportunities arising due to sparser single-cell RNAseq datasets. @ahmedElkoussy https://t.co/RsYM0Hu9N4

Apr 21, 2023 · 9 likes · 2 shares · 61 followers View post →
RNAseq_software
@RnaseqS · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets: With the number of cells measured in single-cell RNA sequencing (scRNA-seq) datasets increasing exponentially and concurrent increased sparsity due to more zero counts… https://t.co/bV6w4WNAHa

Apr 25, 2023 · 3 likes · 313 followers View post →

All mentions

Dieter Stoker
@MasjienLurning · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

May 17, 2023 · 14 shares · 15 followers View post →
Thomas Blein
@BleinThomas · X

RT @jsantoyo: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @…

May 3, 2023 · 8 shares · 390 followers View post →
Bodhi Dharma
@dharma92biol · X

RT @BioDecoded: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets | Genome Biology https://t.co/s1IvR0Xiol…

May 2, 2023 · 1 share · 165 followers View post →
BioDecoded
@BioDecoded · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets | Genome Biology https://t.co/s1IvR0Xiol #Bioinformatics https://t.co/7i62LoS7z5

May 2, 2023 · 14 likes · 1 share · 8,901 followers View post →
Zhe Wang
@WangWaud · X

RT @jsantoyo: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @…

Apr 30, 2023 · 8 shares · 189 followers View post →
Bozeng Tang
@BozengTang · X

RT @jsantoyo: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @…

Apr 30, 2023 · 8 shares · 1,093 followers View post →
Tong
@kurilung · X

RT @jsantoyo: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @…

Apr 30, 2023 · 8 shares · 18 followers View post →
PH
@parham350 · X

RT @jsantoyo: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @…

Apr 29, 2023 · 8 shares · 173 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @jsantoyo: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @…

Apr 29, 2023 · 8 shares · 8,159 followers View post →
Yiliang Ding
@YiliangDing · X

RT @jsantoyo: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @…

Apr 29, 2023 · 8 shares · 3,812 followers View post →
Javier Santoyo
@jsantoyo · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets. #scRNAseq #DataAnalysis #Bioinformatics @GenomeBiology https://t.co/MniUvasB71

Apr 29, 2023 · 11 likes · 8 shares · 6,103 followers View post →
RNAseq_software
@RnaseqS · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets: With the number of cells measured in single-cell RNA sequencing (scRNA-seq) datasets increasing exponentially and concurrent increased sparsity due to more zero counts… https://t.co/bV6w4WNAHa

Apr 25, 2023 · 3 likes · 313 followers View post →
Luis J. Castro-Vega
@LuisJaimeCastr3 · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 25, 2023 · 14 shares · 657 followers View post →
Szu Shuo Lee
@ShuoSzu · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 25, 2023 · 14 shares · 155 followers View post →
Jeroen Gilis
@GilisJeroen · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 25, 2023 · 14 shares · 222 followers View post →
biotech archives
@bot_biotech · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 162 followers View post →
Amarinder
@amarinder_thind · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 172 followers View post →
Edoardo Giacopuzzi
@Supergecko · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 225 followers View post →
Lukas Valihrach
@LukasValihrach · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 3,422 followers View post →
ZheFrench
@ZheFrench · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 411 followers View post →
Lavanya Muthukrishnan
@LavanyaMuthukr3 · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 72 followers View post →
antisense.
@razoralign · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/LibpCbMJvB

Apr 24, 2023 · 15,928 followers View post →
Austin A Varela
@AustinAVarela · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 54 followers View post →
Peter
@BiotechPedro · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 754 followers View post →
Gerard-Bouland
@BoulandGerard · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 61 followers View post →
Soufiane Mourragui
@souf_mourra · X

RT @ahmedElkoussy: If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGer…

Apr 24, 2023 · 14 shares · 498 followers View post →
Ahmed Mahfouz
@ahmedElkoussy · X

If you are interested in representation and modelling of single-cell RNA-seq data, check our recent piece by @BoulandGerard on binary representation. https://t.co/Cireu72wWR We show that many common analysis steps can be done on binarized data with little differences to counts

Apr 24, 2023 · 62 likes · 14 shares · 1,486 followers View post →
casix
@casix_xisac · X

RT @razoralign: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGN…

Apr 23, 2023 · 6 shares · 255 followers View post →
lmthart
@lmthart1 · X

RT @BoulandGerard: Super excited to share our latest work online! In this short report in @GenomeBiology we discuss the consequences and op…

Apr 23, 2023 · 2 shares · 20 followers View post →
ddhb
@ddhb80180543 · X

RT @razoralign: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGN…

Apr 22, 2023 · 6 shares · 15 followers View post →
Soufiane Mourragui
@souf_mourra · X

RT @BoulandGerard: Super excited to share our latest work online! In this short report in @GenomeBiology we discuss the consequences and op…

Apr 22, 2023 · 2 shares · 498 followers View post →
Pavel Honsa
@padza21 · X

RT @razoralign: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGN…

Apr 22, 2023 · 6 shares · 58 followers View post →
Seungho Oh @seunghooh@genomic.social
@dancewithsun · X

RT @razoralign: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGN…

Apr 22, 2023 · 6 shares · 98 followers View post →
AiiHC International Ltd.
@AiihcLtd2022 · X

RT @razoralign: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGN…

Apr 21, 2023 · 6 shares · 818 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @razoralign: Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGN…

Apr 21, 2023 · 6 shares · 574 followers View post →
antisense.
@razoralign · X

Consequences and opportunities arising due to sparser single-cell RNA-seq datasets https://t.co/EfGCoja2kq https://t.co/dGNgGyEtWo

Apr 21, 2023 · 12 likes · 6 shares · 15,928 followers View post →
Gerard-Bouland
@BoulandGerard · X

Super excited to share our latest work online! In this short report in @GenomeBiology we discuss the consequences and opportunities arising due to sparser single-cell RNAseq datasets. @ahmedElkoussy https://t.co/RsYM0Hu9N4

Apr 21, 2023 · 9 likes · 2 shares · 61 followers View post →