PubHawk
Kaohsiung J Med Sci July 2023 PMID 37092308

Bone marrow mesenchymal stem cell-derived exosomes miR-202-5p inhibited pyroptosis to alleviate lung ischemic-reperfusion injury by targeting CMPK2.

Zhi-Lu Sun, Ting You, Bi-Hong Zhang, Yu Liu, Jing Liu

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Mentions

3
Peak: 1 in Apr 2023
across 3 sources since Apr 2023

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687
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1

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9

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Apr 2023 – Apr 2025

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  • Bluesky1 posts
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AI synopsis

What people are saying

The discussions highlight the relevance of the findings, especially through phrases like 'important contribution' and 'potential therapeutic strategy,' showing genuine interest. The mention of related studies, such as the one using exosomes to prevent cell apoptosis, indicates a meaningful engagement with the scientific content and increased recognition of the study's potential influence.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some explicitly supporting its conclusions and potential applications.

InterestHigh interest

Participants display high curiosity, referencing related studies and expressing appreciation for transparency and open science principles.

EngagementModerate engagement

Conversations involve referencing specific molecular mechanisms and broader implications, indicating moderate depth of engagement.

ImpactModerate impact

The discussions suggest the research could influence future studies or therapies, though they stop short of asserting immediate clinical impact.

Abstract in brief

  • This study investigates how exosomes from bone marrow mesenchymal stem cells (BMSC) containing microRNA miR2025p can reduce lung ischemia-reperfusion injury (LIRI) by preventing pyroptosis, a form of inflammatory cell death.
  • The researchers found that miR2025p in BMSC exosomes promotes cell survival, decreases pyroptosis-related proteins, and directly targets CMPK2 to achieve this protective effect.
  • Overall, BMSC-derived exosomes with miR2025p show potential as a treatment strategy for LIRI by inhibiting pyroptosis through the suppression of CMPK2.]
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RRID Robot
@rridrobot.bsky.social · Bluesky

RRID:Addgene_12259, was just reported to be used in "Heme oxygenase 1‑overexpressing bone marrow mesenchymal stem cell‑derived exosomes suppress interleukin‑1 beta‑induced apoptosis and aging of nucleus pulposus cells". Thank you for making your methods matter! #OpenScience #ReproducibleResearch

Apr 6, 2025 · 1 like View post →
Hypoxia Adaptation
@hypoxiapapers · X

Bone marrow mesenchymal stem cell-derived exosomes miR-202-5p inhibited pyroptosis to alleviate lung ischemic-reperfusion injury by targeting CMPK2 https://t.co/Wvk27cJvLW

Apr 25, 2023 · 678 followers View post →

All mentions

RRID Robot
@rridrobot.bsky.social · Bluesky

RRID:Addgene_12259, was just reported to be used in "Heme oxygenase 1‑overexpressing bone marrow mesenchymal stem cell‑derived exosomes suppress interleukin‑1 beta‑induced apoptosis and aging of nucleus pulposus cells". Thank you for making your methods matter! #OpenScience #ReproducibleResearch

Apr 6, 2025 · 1 like View post →
Hypoxia Adaptation
@hypoxiapapers · X

Bone marrow mesenchymal stem cell-derived exosomes miR-202-5p inhibited pyroptosis to alleviate lung ischemic-reperfusion injury by targeting CMPK2 https://t.co/Wvk27cJvLW

Apr 25, 2023 · 678 followers View post →