Nat Commun April 2023 PMID 37095084

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility.

Daiji Kiyozumi, Kentaro Shimada, Michael Chalick, Chihiro Emori, Mayo Kodani, Seiya Oura, Taichi Noda, Tsutomu Endo, Martin M Matzuk, Daniel H Wreschner, Masahito Ikawa

Mentions

23
Peak: 4 in May 2023
across 4 sources since Apr 2023

Extended reach

6,562
potential audience

Total likes

7

Video views

29

Mentions per month

Apr 2023 – Jul 2023

Where it's discussed

  • X / Twitter9 posts
  • News9 articles
  • Blogs4 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall discussions highlight the discovery of NICOL as a key factor in sperm maturation, with phrases such as 'regulates lumicrine-mediated sperm maturation' indicating technical appreciation, and words like 'discovered' and 'significant breakthrough' reflecting excitement and recognition of its potential impact on reproductive health research.

AgreementModerate agreement

Most discussions support the importance of NICOL in sperm maturation and male fertility, reflecting a consensus on the article's significance.

InterestHigh interest

Posts show high enthusiasm and curiosity about the discovery, with phrases like 'discovered the protein behind successful sperm maturation' and 'significant breakthrough.'

EngagementModerate engagement

Some posts reference specifics about the research teams and the journal publication, indicating a moderate level of detailed engagement.

ImpactHigh impact

The emphasis on the discovery's potential relevance to fertility research and the mention of awards suggest a high perceived impact.

Abstract in brief

  • Mammalian sperm must mature in the epididymis after being produced in the testis to be fully functional.
  • This maturation is influenced by lumicrine signalling, which involves signals from the testis promoting sperm differentiation in the epididymis, though the mechanisms were not well understood.
  • A protein called NICOL is shown to be vital for this process; without it, male mice become sterile due to issues with sperm maturation, but fertility can be restored by expressing NICOL in testicular cells.

Top posts

Most liked on X and Bluesky
DAIJI KIYOZUMI
@DaijiKiyozumi · X

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility | Nature Communications https://t.co/tWvsG8b13l 以下2021 NIKON JOICO AWARD受賞成果研究の続報となります。 https://t.co/p6B2PMHcSH

Apr 25, 2023 · 3 likes · 2 shares · 38 followers View post →
Gitter-Smolarz Library of Life Sciences & Medicine
@medliblibrary · X

A Joint Japanese-Israeli team led by Prof. Daniel Wreschner of @ShmunisR @LifeScienceTAU, @TelAvivUni discovered the protein behind successful sperm maturation and male fertility. Article in @NatureComms: https://t.co/JTblzzdDsY https://t.co/8jA4GUGBf9

Jun 27, 2023 · 2 likes · 1 share · 144 followers View post →
RIMD-Osaka Univ.
@Biken_RIMD_en · X

The Article from Ikawa Lab was published in Nat. Commun "A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility” https://t.co/14LbcKYzol #ResearchInstituteforMicrobialDiseases #osakauniversity #RIMD #sperm #NICOL https://t.co/Ol8AcMzxB5

May 11, 2023 · 2 likes · 1 share · 133 followers View post →
ニコンソリューションズ/バイオサイエンス
@nikonsolutions · X

RT @DaijiKiyozumi: A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility | Nature Communications…

Apr 26, 2023 · 2 shares · 3,674 followers View post →
ROGAPISS
@MISCH2281 · X

RT @DaijiKiyozumi: A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility | Nature Communications…

May 8, 2023 · 2 shares · 1,310 followers View post →
Cancer Papers
@CancerPapers · X

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility https://t.co/i12u8NdvWa

May 15, 2023 · 1,003 followers View post →

All mentions

Shmunis School of Biomedicine and Cancer Research
@ShmunisR · X

RT @medliblibrary: A Joint Japanese-Israeli team led by Prof. Daniel Wreschner of @ShmunisR @LifeScienceTAU, @TelAvivUni discovered the pro…

Jul 6, 2023 · 1 share · 136 followers View post →
Gitter-Smolarz Library of Life Sciences & Medicine
@medliblibrary · X

A Joint Japanese-Israeli team led by Prof. Daniel Wreschner of @ShmunisR @LifeScienceTAU, @TelAvivUni discovered the protein behind successful sperm maturation and male fertility. Article in @NatureComms: https://t.co/JTblzzdDsY https://t.co/8jA4GUGBf9

Jun 27, 2023 · 2 likes · 1 share · 144 followers View post →
Cancer Papers
@CancerPapers · X

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility https://t.co/i12u8NdvWa

May 15, 2023 · 1,003 followers View post →
DAIJI KIYOZUMI
@DaijiKiyozumi · X

RT @Biken_RIMD_en: The Article from Ikawa Lab was published in Nat. Commun "A small secreted protein NICOL regulates lumicrine-mediated spe…

May 11, 2023 · 1 share · 38 followers View post →
RIMD-Osaka Univ.
@Biken_RIMD_en · X

The Article from Ikawa Lab was published in Nat. Commun "A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility” https://t.co/14LbcKYzol #ResearchInstituteforMicrobialDiseases #osakauniversity #RIMD #sperm #NICOL https://t.co/Ol8AcMzxB5

May 11, 2023 · 2 likes · 1 share · 133 followers View post →
ROGAPISS
@MISCH2281 · X

RT @DaijiKiyozumi: A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility | Nature Communications…

May 8, 2023 · 2 shares · 1,310 followers View post →
ニコンソリューションズ/バイオサイエンス
@nikonsolutions · X

RT @DaijiKiyozumi: A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility | Nature Communications…

Apr 26, 2023 · 2 shares · 3,674 followers View post →
DAIJI KIYOZUMI
@DaijiKiyozumi · X

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility | Nature Communications https://t.co/tWvsG8b13l 以下2021 NIKON JOICO AWARD受賞成果研究の続報となります。 https://t.co/p6B2PMHcSH

Apr 25, 2023 · 3 likes · 2 shares · 38 followers View post →
DAIJI KIYOZUMI
@DaijiKiyozumi · X

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility | Nature Communications https://t.co/tWvsG8b13l https://t.co/OOGpqBvbEo

Apr 25, 2023 · 38 followers View post →