Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/nJq27aYICe
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice.
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Dec 2021 – Sep 2025Where it's discussed
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AI synopsis
What people are saying
Many discussions highlight key findings from the research, such as the role of GPNMB in aging and the vaccine's ability to improve health and lifespan in mice. Words like 'impressive' and 'game-changing' suggest a tone of enthusiasm, while terms such as 'potential breakthrough' highlight the transformative implications of the findings.
The majority of the discussions express strong support for the findings of the publication, often echoing its conclusions about the positive effects of senolytic vaccination.
Participants show a high level of curiosity about the potential applications and implications of the research.
While many posts provide summaries or basic reactions, some delve into more detailed aspects of the study, suggesting varying levels of engagement.
There is a consensus among users that this research could significantly influence the future of treatments for age-related ailments.
Abstract in brief
- Recent research shows that eliminating senescent cells (senolysis) can enhance health during aging in mice.
- A new potential target for senolytic therapy is the glycoprotein GPNMB, which is found in higher amounts in senescent cells and is linked to conditions like atherosclerosis.
- Immunizing mice against GPNMB reduced these senescent cells and improved various aging-related health issues, indicating that targeting seno-antigens through vaccination might lead to innovative senolytic treatments.
Top posts
Most liked on X and BlueskySenolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://t.co/SDfVwvqHkm
NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led to improvements in several #aging-related phenotypes and prolonged the #lifespan of a progeroid mouse model. https://t.co/V7BtTt5q11
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/ZiRnNssxv1
加齢性疾患の治療を目指した老化細胞ワクチン! 老化マウスの血管内皮から老化抗原としてGPNMBを同定。その抗原に対するワクチンを作成し、糖尿病、動脈硬化モデルマウスの病態、フレイルの改善! 昨年の12月にNature Agingにて掲載された論文を今頃。 #2022年論文紹介70 https://t.co/c6ARnPglaZ
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/70McLurOKs
All mentions
Exploring a Vaccine that Targets Senescent Cells to Combat Aging
The presence of senescent cells increases with age and may contribute to aging-related health decline. This video discusses a new study proposing a senolytic vaccine targeting Gpnmb, a glycoprotein linked to these…
How we might get a vaccine against aging
@SchonfeldGaston @BioProtocol
現実的には「がん化しない」老化細胞除去剤の開発が必須。 そこで、老化細胞抗原 #SAGP を特定しそれを標的とした老化細胞除去ワクチンを開発。 (SAGPはストレスによって増加し老化細胞のsurvial factorとして働く。これを除去することで組織が再生されるというメカニズム) https://t.co/t9wKZhjnvb https://t.co/bZJEEmGc5X
Suda, M., Shimizu, I., Katsuumi, G. et al. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging 1, 1117–1126 (2021). https://t.co/Lp5kgtlTYo
RT @LifeboatHQ: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…
RT @LifeboatHQ: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/qWDPMzTBa5
Original article: https://t.co/1aNN9GFLRi
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/ubA4vy3d6m
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/oNRg2cSKKV https://t.co/AtO0jZ4Dh1
Japanese scientists created a "vaccine" against getting old: Read more ⬇️⬇️⬇️ https://t.co/aSrKY10Cwu "Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice" https://t.co/9VN82KUvWb
RT @babataiki326: 加齢性疾患の治療を目指した老化細胞ワクチン! 老化マウスの血管内皮から老化抗原としてGPNMBを同定。その抗原に対するワクチンを作成し、糖尿病、動脈硬化モデルマウスの病態、フレイルの改善! 昨年の12月にNature Agingにて掲載さ…
https://t.co/sTMt8uflem
加齢性疾患の治療を目指した老化細胞ワクチン! 老化マウスの血管内皮から老化抗原としてGPNMBを同定。その抗原に対するワクチンを作成し、糖尿病、動脈硬化モデルマウスの病態、フレイルの改善! 昨年の12月にNature Agingにて掲載された論文を今頃。 #2022年論文紹介70 https://t.co/c6ARnPglaZ
RT @DrLBoominathan: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/bQg9OrAkmn
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. https://t.co/pORejg8J5Q
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/t9UMRcvnVI To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/XegoMa9H6D
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/mdY0Euf22P
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/e6Qf4s2rAE
RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…
RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…
Altmetric – Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/aMpby84RZy There I am XD This is a neat page. https://t.co/jNvgGj6ZdY
Recently, https://t.co/2BoCY8Ne3k in @NatureAging showed the development of a vaccine against senescent cells based on the surface protein GPNMB.
RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…
RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…
抗老化ワクチン
うちの大学は契約してないから全部読めんかった(/ω\) --- https://t.co/ZKl57BdKrs
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/YwBVfoKKyr
RT @Orlando_uy: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. htt…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. https://t.co/TpoqRPkZCA
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/VgLQPv4MpN
いずれも有意に減少。実際の老化の指標である敏捷性テストの成績も遥かに良く、わずかに寿命の延長も確認。副作用は特にありませんでしが、ヒトへの応用に際しては、GPNMBタンパク質が老化細胞以外の様々な細胞に存在するため、標的外効果の可能性を排除する必要がありますhttps://t.co/cUndN6NkW5
@ratwell0x Btw the extended lifespan was in male mice. Suda et al 2021: “Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice”
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/GugTNK2lKj
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/BjavcXQ2zU
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/AkSmurLXwG
RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…
NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led to improvements in several #aging-related phenotypes and prolonged the #lifespan of a progeroid mouse model. https://t.co/V7BtTt5q11
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/70McLurOKs
RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…
RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…
なんと、なんと、なんと! Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/TLqjfDbsZo
RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/xPaZjIQeJk
RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…
RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…
RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…
RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/J4vAjcdQO9
RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…
RT @MG_Vizioli: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/nJq27aYICe
RT @MG_Vizioli: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://…
RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/ZiRnNssxv1
RT @MG_Vizioli: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://…
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://t.co/SDfVwvqHkm
1/2 Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/t9UMRcdeHA "Genetic ablation of Gpnmb-positive cells attenuated senescence in adipose tissue and improved systemic metabolic abnormalities."
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/TD0Fnbe7HG
2021/12/10|順天堂大学リリース 老化細胞除去ワクチンの開発に成功 https://t.co/VtCJBQuoNA 2021/12/10|Nature Aging Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/92k5OEv3RF https://t.co/7TySsV6IRT