Nat Aging December 2021 PMID 37117524

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice.

Masayoshi Suda, Ippei Shimizu, Goro Katsuumi, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Naomi Matsumoto, Yutaka Yoshida, Ryuta Mikawa, Akihiro Katayama, Jun Wada, Masahide Seki, Yutaka Suzuki, Atsushi Iwama, Hironori Nakagami

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Mentions

372
Peak: 42 in Dec 2021
across 6 sources since Dec 2021

Extended reach

235,159
potential audience

Total likes

927

Video views

22,788

Mentions per month

Dec 2021 – Sep 2025

Where it's discussed

  • News286 articles
  • X / Twitter60 posts
  • Blogs16 articles
  • Reddit5 posts
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many discussions highlight key findings from the research, such as the role of GPNMB in aging and the vaccine's ability to improve health and lifespan in mice. Words like 'impressive' and 'game-changing' suggest a tone of enthusiasm, while terms such as 'potential breakthrough' highlight the transformative implications of the findings.

AgreementStrong agreement

The majority of the discussions express strong support for the findings of the publication, often echoing its conclusions about the positive effects of senolytic vaccination.

InterestHigh interest

Participants show a high level of curiosity about the potential applications and implications of the research.

EngagementModerate engagement

While many posts provide summaries or basic reactions, some delve into more detailed aspects of the study, suggesting varying levels of engagement.

ImpactHigh impact

There is a consensus among users that this research could significantly influence the future of treatments for age-related ailments.

Abstract in brief

  • Recent research shows that eliminating senescent cells (senolysis) can enhance health during aging in mice.
  • A new potential target for senolytic therapy is the glycoprotein GPNMB, which is found in higher amounts in senescent cells and is linked to conditions like atherosclerosis.
  • Immunizing mice against GPNMB reduced these senescent cells and improved various aging-related health issues, indicating that targeting seno-antigens through vaccination might lead to innovative senolytic treatments.

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/nJq27aYICe

Dec 11, 2021 · 46 likes · 7 shares · 30,511 followers View post →
Maria Grazia Vizioli
@MG_Vizioli · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://t.co/SDfVwvqHkm

Dec 11, 2021 · 30 likes · 3 shares · 1,763 followers View post →
Nature Aging
@NatureAging · X

NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led to improvements in several #aging-related phenotypes and prolonged the #lifespan of a progeroid mouse model. https://t.co/V7BtTt5q11

Dec 13, 2021 · 21 likes · 5 shares · 18,632 followers View post →
Agingdoc
@agingdoc1 · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/ZiRnNssxv1

Dec 11, 2021 · 19 likes · 5 shares · 41,341 followers View post →
Taiki Baba
@babataiki326 · X

加齢性疾患の治療を目指した老化細胞ワクチン! 老化マウスの血管内皮から老化抗原としてGPNMBを同定。その抗原に対するワクチンを作成し、糖尿病、動脈硬化モデルマウスの病態、フレイルの改善! 昨年の12月にNature Agingにて掲載された論文を今頃。 #2022年論文紹介70 https://t.co/c6ARnPglaZ

May 13, 2022 · 11 likes · 1 share · 2,706 followers View post →
Han Li Pasteur
@HanLi_Pasteur · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/70McLurOKs

Dec 12, 2021 · 7 likes · 577 followers View post →

All mentions

Aubrai
@Aubrai_ · X

@SchonfeldGaston @BioProtocol

Sep 20, 2025 · 10,811 followers View post →
七夕
@K212462681 · X

現実的には「がん化しない」老化細胞除去剤の開発が必須。 そこで、老化細胞抗原 #SAGP を特定しそれを標的とした老化細胞除去ワクチンを開発。 (SAGPはストレスによって増加し老化細胞のsurvial factorとして働く。これを除去することで組織が再生されるというメカニズム) https://t.co/t9wKZhjnvb https://t.co/bZJEEmGc5X

Dec 25, 2023 · 236 followers View post →
john morley
@drjohnmorley · X

Suda, M., Shimizu, I., Katsuumi, G. et al. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging 1, 1117–1126 (2021). https://t.co/Lp5kgtlTYo

Sep 19, 2023 · 1 like · 8,322 followers View post →
Sanath Janaka Gunawardena
@5anath666 · X

RT @LifeboatHQ: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…

Aug 12, 2023 · 2 shares · 687 followers View post →
The ReNeural Project
@ReNeural · X

RT @LifeboatHQ: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…

Aug 12, 2023 · 2 shares · 405 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/qWDPMzTBa5

Aug 12, 2023 · 3 likes · 2 shares · 31,615 followers View post →
The Journal of Cardiovascular Aging
@JCA_Journal · X

Original article: https://t.co/1aNN9GFLRi

Aug 1, 2023 · 1,842 followers View post →
Cardio-Targets
@CardioTargets · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/ubA4vy3d6m

Apr 29, 2023 · 153 followers View post →
Adipose Papers
@adipose_papers · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/oNRg2cSKKV https://t.co/AtO0jZ4Dh1

Apr 29, 2023 · 2,443 followers View post →
Shadira
@MsMonsanto · X

Japanese scientists created a "vaccine" against getting old: Read more ⬇️⬇️⬇️ https://t.co/aSrKY10Cwu "Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice" https://t.co/9VN82KUvWb

Dec 22, 2022 · 4,175 followers View post →
のた
@54xc8fwpRCO5igG · X

RT @babataiki326: 加齢性疾患の治療を目指した老化細胞ワクチン! 老化マウスの血管内皮から老化抗原としてGPNMBを同定。その抗原に対するワクチンを作成し、糖尿病、動脈硬化モデルマウスの病態、フレイルの改善! 昨年の12月にNature Agingにて掲載さ…

Sep 11, 2022 · 1 share · 18 followers View post →
晶洞II
@ishikoro_geo · X

https://t.co/sTMt8uflem

May 21, 2022 · 886 followers View post →
Taiki Baba
@babataiki326 · X

加齢性疾患の治療を目指した老化細胞ワクチン! 老化マウスの血管内皮から老化抗原としてGPNMBを同定。その抗原に対するワクチンを作成し、糖尿病、動脈硬化モデルマウスの病態、フレイルの改善! 昨年の12月にNature Agingにて掲載された論文を今頃。 #2022年論文紹介70 https://t.co/c6ARnPglaZ

May 13, 2022 · 11 likes · 1 share · 2,706 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

RT @DrLBoominathan: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice…

Feb 27, 2022 · 1 share · 877 followers View post →
ノリオ
@norioNY · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/bQg9OrAkmn

Feb 7, 2022 · 560 followers View post →
Glenn Vallecillos MD FACS
@GVMD · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. https://t.co/pORejg8J5Q

Jan 28, 2022 · 1,525 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/t9UMRcvnVI To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/XegoMa9H6D

Jan 19, 2022 · 1 like · 1 share · 877 followers View post →
ことだま
@cotodaman · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/mdY0Euf22P

Jan 15, 2022 · 478 followers View post →
Rina Saltman
@rinatie_ceo · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/e6Qf4s2rAE

Jan 13, 2022 · 3,558 followers View post →
np.dot(Daniel, Wiczew) + B
@DanielWiczew · X

RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…

Jan 4, 2022 · 5 shares · 877 followers View post →
Luis I. Prieto
@LuisIPrieto1 · X

RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…

Dec 28, 2021 · 5 shares · 115 followers View post →
Colonel Innomen • Ethical Hedonist
@Innomen · X

Altmetric – Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/aMpby84RZy There I am XD This is a neat page. https://t.co/jNvgGj6ZdY

Dec 27, 2021 · 1,483 followers View post →
cga
@cgagct · X

Recently, https://t.co/2BoCY8Ne3k in @NatureAging showed the development of a vaccine against senescent cells based on the surface protein GPNMB.

Dec 25, 2021 · 1 like · 459 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…

Dec 22, 2021 · 5 shares · 246 followers View post →
Nature Aging
@NatureAging · X

RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…

Dec 22, 2021 · 5 shares · 18,632 followers View post →
グク
@sanfranbays · X

抗老化ワクチン

Dec 21, 2021 · 1 like · 2,793 followers View post →
Kaamuland
@kaamuland · X

うちの大学は契約してないから全部読めんかった(/ω\) --- https://t.co/ZKl57BdKrs

Dec 20, 2021 · 144 followers View post →
Cecile Tamura
@ceciletamura · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/YwBVfoKKyr

Dec 19, 2021 · 2,868 followers View post →
Carlos Colmenero
@colme99 · X

RT @Orlando_uy: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. htt…

Dec 18, 2021 · 1 share · 77 followers View post →
Orlando_uy
@Orlando_uy · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. https://t.co/TpoqRPkZCA

Dec 18, 2021 · 1 share · 690 followers View post →
Oleg A. Chagin
@Oleg_A_Chagin · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/VgLQPv4MpN

Dec 17, 2021 · 1,128 followers View post →
サイエンスあれこれ
@sarekore · X

いずれも有意に減少。実際の老化の指標である敏捷性テストの成績も遥かに良く、わずかに寿命の延長も確認。副作用は特にありませんでしが、ヒトへの応用に際しては、GPNMBタンパク質が老化細胞以外の様々な細胞に存在するため、標的外効果の可能性を排除する必要がありますhttps://t.co/cUndN6NkW5

Dec 17, 2021 · 924 followers View post →
Hubert von Superluxus
@vonSuperluxus · X

@ratwell0x Btw the extended lifespan was in male mice. Suda et al 2021: “Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice”

Dec 16, 2021 · 153 followers View post →
IMCB_CBT
@CellbiologyT · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/GugTNK2lKj

Dec 16, 2021 · 51 followers View post →
David Charles ♋️
@David_CharlesDC · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/BjavcXQ2zU

Dec 15, 2021 · 3,398 followers View post →
antonella santuccione chadha
@ChadhaAnt · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/AkSmurLXwG

Dec 15, 2021 · 5 likes · 699 followers View post →
Maria Avrutsky
@MariaAvrutsky · X

RT @NatureAging: NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led…

Dec 13, 2021 · 5 shares · 126 followers View post →
Nature Aging
@NatureAging · X

NEW: Development of a #vaccine against a membrane-bound seno-antigen (GPNMB) as a new #senolytic approach. The vaccine led to improvements in several #aging-related phenotypes and prolonged the #lifespan of a progeroid mouse model. https://t.co/V7BtTt5q11

Dec 13, 2021 · 21 likes · 5 shares · 18,632 followers View post →
Han Li Pasteur
@HanLi_Pasteur · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/70McLurOKs

Dec 12, 2021 · 7 likes · 577 followers View post →
Alan Meng
@AlanMeng3 · X

RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…

Dec 12, 2021 · 7 shares · 17 followers View post →
Gonzalo’s Lab
@gonzalo_lab · X

RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…

Dec 12, 2021 · 7 shares · 472 followers View post →
ビビ
@bibinotsubuyaki · X

なんと、なんと、なんと! Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/TLqjfDbsZo

Dec 12, 2021 · 2 likes · 430 followers View post →
Filipe Rebello
@FilipeRebello1 · X

RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…

Dec 12, 2021 · 5 shares · 16 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/xPaZjIQeJk

Dec 12, 2021 · 1 like · 2,240 followers View post →
FVP
@FVPetro · X

RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…

Dec 11, 2021 · 5 shares · 1,165 followers View post →
Eduardo Silva-Pavez
@EduSilvaPavez · X

RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…

Dec 11, 2021 · 7 shares · 134 followers View post →
DomTheBoss
@uberrimaefidei1 · X

RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…

Dec 11, 2021 · 5 shares · 622 followers View post →
Daniel Klaus Fabian
@DK_Fabian · X

RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…

Dec 11, 2021 · 7 shares · 272 followers View post →
Diego Delgado
@DiegoDoZr · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice | Nature Aging https://t.co/J4vAjcdQO9

Dec 11, 2021 · 238 followers View post →
Juan Fafián-Labora
@fafian_juan · X

RT @AgingBiology: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice ht…

Dec 11, 2021 · 7 shares · 1,006 followers View post →
Claire E. Hills
@Chillslincoln79 · X

RT @MG_Vizioli: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://…

Dec 11, 2021 · 3 shares · 1,639 followers View post →
Aging Science News
@AgingBiology · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/nJq27aYICe

Dec 11, 2021 · 46 likes · 7 shares · 30,511 followers View post →
Yann F. Lecerf
@Yann_F_Lecerf · X

RT @MG_Vizioli: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://…

Dec 11, 2021 · 3 shares · 340 followers View post →
Babalola Joshua Adekunle Taiwo
@babalolaadekun1 · X

RT @agingdoc1: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice http…

Dec 11, 2021 · 5 shares · 1,275 followers View post →
Agingdoc
@agingdoc1 · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/ZiRnNssxv1

Dec 11, 2021 · 19 likes · 5 shares · 41,341 followers View post →
Juan Fafián-Labora
@fafian_juan · X

RT @MG_Vizioli: Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://…

Dec 11, 2021 · 3 shares · 1,006 followers View post →
Maria Grazia Vizioli
@MG_Vizioli · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in old mice. https://t.co/SDfVwvqHkm

Dec 11, 2021 · 30 likes · 3 shares · 1,763 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

1/2 Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/t9UMRcdeHA "Genetic ablation of Gpnmb-positive cells attenuated senescence in adipose tissue and improved systemic metabolic abnormalities."

Dec 11, 2021 · 877 followers View post →
Fútbol
@ikumen33 · X

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/TD0Fnbe7HG

Dec 10, 2021 · 1 like · 484 followers View post →
maru
@pap_maru · X

2021/12/10|順天堂大学リリース 老化細胞除去ワクチンの開発に成功 https://t.co/VtCJBQuoNA 2021/12/10|Nature Aging Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice https://t.co/92k5OEv3RF https://t.co/7TySsV6IRT

Dec 10, 2021 · 1 like · 35 followers View post →