In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @altos_labs off to a great start. https://t.co/bi8qedOoIE
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice.
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Mar 2022 – Oct 2025Where it's discussed
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News158 articles
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What people are saying
Across the various discussions, commenters express excitement about the pioneering work on partial reprogramming, emphasizing phrases like 'reversing aging' and 'game changer,' which reflect both high interest and perceived high impact. The tone suggests a strong agreement on the significance of the findings, with some posts referencing the methodology and promising applications, indicating a moderate level of engagement.
Most discussions recognize the significance of the study, with many expressing enthusiasm about the potential of partial reprogramming to reverse aging.
Posts demonstrate high interest, highlighting the groundbreaking nature of the findings and its implications for aging research.
Several social discussions reference specific methods (e.g., Yamanaka factors) and emphasize the transformative potential, indicating a moderate depth of engagement.
The majority agree that this research could have a substantial impact, with some calling it a 'game changer' and emphasizing its potential to revolutionize longevity studies.
Abstract in brief
- Long-term partial reprogramming using factors like Oct4, Sox2, Klf4, and cMyc can reverse signs of aging in tissues and improve overall health in mice, with effects depending on how long the treatment lasts.
- The process involves resetting the epigenetic clock and altering gene expression, particularly reducing inflammation, cell aging, and stress responses, leading to tangible rejuvenation in organs such as kidneys and skin.
- Longer treatment durations are more effective than shorter ones in delaying aging-related changes, suggesting that carefully designed, extended reprogramming protocols could be a safe and promising approach to combat aging.
Top posts
Most liked on X and BlueskyJuan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/IrZJbnUCHc https://t.co/xv4CdPqMVb https://t.co/pRNMPc2naW
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/iRzmC7xFIc
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/qtxGlHk4sw
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice: https://t.co/cW3lXRQ43T
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/yxvofSFXMA
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Key Breakthroughs in Longevity Research: Insights from 2022
What a year 2022 has been for longevity research. This video discusses crucial findings including the effects of old blood on young mice and how senolytic drugs can mitigate these impacts. Join us in exploring the…
Enhanced Rejuvenation Through Reprogramming in Aging Mice
This video explores recent research on in vivo partial reprogramming using Yamanaka factors in aging mice. It examines how varying treatment durations influence molecular and tissue-level rejuvenation, including effects…
RT @NatureJapan: Juan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alter…
RT @NatureJapan: Juan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alter…
Juan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/IrZJbnUCHc https://t.co/xv4CdPqMVb https://t.co/pRNMPc2naW
@theodorus5 @MikhailBatin "Long-term partial reprogramming lead to rejuvenating effects in different tissues, such as the kidney and skin, and at the organismal level;" https://t.co/NVlBazrrTN Michael Levin leads an alternative higher level approach, albeit not as far along.
Highlight – an older paper by Juan Carlos Izpisua Belmonte & colleagues published Mar 2022 in @NatureAging "In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice" https://t.co/e0dEzQZOzM
RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…
RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…
RT @NOMIX_AI: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice #longevity #CODIS #B…
RT @NOMIX_AI: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice #longevity #CODIS #B…
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice #longevity #CODIS #BIOCLOCK https://t.co/5lxdvwZaeW
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/CCT7Ry2Zqa
‘ In Vivo Partial Reprogramming: Alters age-associated molecular changes, during physiological aging, in mice
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/YehyD8JVNM
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/GLk2eB1xGt
「In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice」 細胞を部分的に若返らせてマウスを若返らせる実験についての論文。様々な組織で若返りが認められ、効果の程度は投与期間によることが分かった。 → https://t.co/DofOFG3QEw
RT @gencivek: ‘’Bilimde Bu Hafta" köşemiz 06.03.2022 – 12.03.2022
https://t.co/GDubVMGBrz In vivo partial #reprogramming alters age-associated molecular changes during physiological #aging in mice. #epigenetic #DNA #doxycycline #reversingAging #invecchiamento #Yamanaka #epigenetica
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging | It's really safe? #山中因子
RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. https://t.co/GBHlKmVDlB
The fountain of youth…. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/bI15zeKYBk
RT @JoelSercel: @PeterDiamandis Seminal new work published in Nature Aging just hit my inbox today. Yamanaka factor reprograming now PROVEN…
#STEMCELL #AGING Published: 07 March 2022 In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice Kristen C. Browder, Pradeep Reddy, …Juan Carlos Izpisua Belmonte Show authors Nature Aging (2022)
@PeterDiamandis Seminal new work published in Nature Aging just hit my inbox today. Yamanaka factor reprograming now PROVEN to basically reverse aging in wild type mice. See "In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice". This is HUGE
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/6A1ftmf2Ju
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/iRzmC7xFIc
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/sMYsPsaAKF 长期的部分重编程方案改变了小鼠生理衰老过程中与年龄相关的分子变化,使不同组织(例如肾脏和皮肤)恢复活力,效果取决于重编程持续时间。
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/casVfFR0Da
RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/i4v1RoPAM7
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/Ywrq10EDVF 読めないんだがこれは結局寿命が伸びるという話なのかそうではないという話なのか
Ah! Quién fuera ratón! In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/mABMWXJjNq
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice Another paper by @alto... https://t.co/UzZqRDSMXG
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/yxvofSFXMA
RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…
RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/qtxGlHk4sw
RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @altos_labs off to a great start. https://t.co/bi8qedOoIE
RT @ShorterLab: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice: https://t.co/cW3l…
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice: https://t.co/cW3lXRQ43T