Nat Aging March 2022 PMID 37118377

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice.

Kristen C Browder, Pradeep Reddy, Mako Yamamoto, Amin Haghani, Isabel Guillen Guillen, Sanjeeb Sahu, Chao Wang, Yosu Luque, Javier Prieto, Lei Shi, Kensaku Shojima, Tomoaki Hishida, Zijuan Lai, Qingling Li, Feroza K Choudhury

Mentions

230
Peak: 30 in Mar 2022
across 6 sources since Mar 2022

Extended reach

323,294
potential audience

Total likes

2,037

Video views

70,752

Mentions per month

Mar 2022 – Oct 2025

Where it's discussed

  • News158 articles
  • X / Twitter41 posts
  • Blogs18 articles
  • Facebook9 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Across the various discussions, commenters express excitement about the pioneering work on partial reprogramming, emphasizing phrases like 'reversing aging' and 'game changer,' which reflect both high interest and perceived high impact. The tone suggests a strong agreement on the significance of the findings, with some posts referencing the methodology and promising applications, indicating a moderate level of engagement.

AgreementModerate agreement

Most discussions recognize the significance of the study, with many expressing enthusiasm about the potential of partial reprogramming to reverse aging.

InterestHigh interest

Posts demonstrate high interest, highlighting the groundbreaking nature of the findings and its implications for aging research.

EngagementModerate engagement

Several social discussions reference specific methods (e.g., Yamanaka factors) and emphasize the transformative potential, indicating a moderate depth of engagement.

ImpactHigh impact

The majority agree that this research could have a substantial impact, with some calling it a 'game changer' and emphasizing its potential to revolutionize longevity studies.

Abstract in brief

  • Long-term partial reprogramming using factors like Oct4, Sox2, Klf4, and cMyc can reverse signs of aging in tissues and improve overall health in mice, with effects depending on how long the treatment lasts.
  • The process involves resetting the epigenetic clock and altering gene expression, particularly reducing inflammation, cell aging, and stress responses, leading to tangible rejuvenation in organs such as kidneys and skin.
  • Longer treatment durations are more effective than shorter ones in delaying aging-related changes, suggesting that carefully designed, extended reprogramming protocols could be a safe and promising approach to combat aging.

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @altos_labs off to a great start. https://t.co/bi8qedOoIE

Mar 7, 2022 · 19 likes · 7 shares · 41,779 followers View post →
Nature Japan
@NatureJapan · X

Juan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/IrZJbnUCHc https://t.co/xv4CdPqMVb https://t.co/pRNMPc2naW

Oct 15, 2025 · 12 likes · 2 shares · 91,183 followers View post →
Vicen Perez-Garcia
@Vicensella · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/iRzmC7xFIc

Mar 8, 2022 · 7 likes · 1,453 followers View post →
BüttnerLab
@ButtnerLab · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/qtxGlHk4sw

Mar 7, 2022 · 4 likes · 913 followers View post →
ShorterLab
@ShorterLab · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice: https://t.co/cW3lXRQ43T

Mar 7, 2022 · 3 likes · 1 share · 12,100 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/yxvofSFXMA

Mar 7, 2022 · 3 likes · 4,750 followers View post →

All mentions

PFR_18
@pfr_18 · X

RT @NatureJapan: Juan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alter…

Oct 16, 2025 · 2 shares · 15 followers View post →
Time crystal / Planck time
@TimePlanck · X

RT @NatureJapan: Juan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alter…

Oct 15, 2025 · 2 shares · 162 followers View post →
Nature Japan
@NatureJapan · X

Juan Carlos Izpisua Belmonte、山本 真子、庄嶋 健作、菱田 友昭 氏らのマウスの生理的老化に伴う分子変化に関する@NatureAging #論文 In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/IrZJbnUCHc https://t.co/xv4CdPqMVb https://t.co/pRNMPc2naW

Oct 15, 2025 · 12 likes · 2 shares · 91,183 followers View post →
ThruTheFog
@HyperSapient · X

@theodorus5 @MikhailBatin "Long-term partial reprogramming lead to rejuvenating effects in different tissues, such as the kidney and skin, and at the organismal level;" https://t.co/NVlBazrrTN Michael Levin leads an alternative higher level approach, albeit not as far along.

Jun 4, 2024 · 77 followers View post →
Andreea Nitescu RD MSc
@AndreeaNRD · X

Highlight – an older paper by Juan Carlos Izpisua Belmonte & colleagues published Mar 2022 in @NatureAging "In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice" https://t.co/e0dEzQZOzM

Aug 26, 2023 · 1 like · 1,304 followers View post →
Yotam Cohen
@Yot_Coh · X

RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…

Mar 21, 2023 · 7 shares · 878 followers View post →
Dr_Mombasa
@dr_mombasa · X

RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…

Mar 20, 2023 · 7 shares · 174 followers View post →
BIOCOACH
@BIOCOACHAPP · X

RT @NOMIX_AI: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice #longevity #CODIS #B…

May 29, 2022 · 2 shares · 144 followers View post →
michaelreuter
@michaelreuter · X

RT @NOMIX_AI: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice #longevity #CODIS #B…

May 29, 2022 · 2 shares · 4,303 followers View post →
NOMIX
@NOMIX_AI · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice #longevity #CODIS #BIOCLOCK https://t.co/5lxdvwZaeW

May 29, 2022 · 2 likes · 2 shares · 596 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/CCT7Ry2Zqa

Apr 23, 2022 · 31,603 followers View post →
QuantumAI+Crispr3D=QuInCy=QAI&C3D=LA
@1LEOOEL1 · X

‘ In Vivo Partial Reprogramming: Alters age-associated molecular changes, during physiological aging, in mice

Apr 19, 2022 · 2,960 followers View post →
ぜのぱす(初代_凍結から快復)
@Xenopus007 · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/YehyD8JVNM

Mar 21, 2022 · 850 followers View post →
Diego Delgado
@DiegoDoZr · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/GLk2eB1xGt

Mar 13, 2022 · 233 followers View post →
Toshihico Shiracawa
@candidusflumen · X

「In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice」 細胞を部分的に若返らせてマウスを若返らせる実験についての論文。様々な組織で若返りが認められ、効果の程度は投与期間によることが分かった。 → https://t.co/DofOFG3QEw

Mar 13, 2022 · 1,737 followers View post →
Ayşegül Hivda Tanrıverdi Kaya
@aysegul_eng · X

RT @gencivek: ‘’Bilimde Bu Hafta" köşemiz 06.03.2022 – 12.03.2022

Mar 12, 2022 · 1 share · 92 followers View post →
m. michele d'onofrio
@variedeventual · X

https://t.co/GDubVMGBrz In vivo partial #reprogramming alters age-associated molecular changes during physiological #aging in mice. #epigenetic #DNA #doxycycline #reversingAging #invecchiamento #Yamanaka #epigenetica

Mar 12, 2022 · 171 followers View post →
Rina Saltman
@rinatie_ceo · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging | It's really safe? #山中因子

Mar 11, 2022 · 3,560 followers View post →
blake smithson
@blakesmithson1 · X

RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…

Mar 10, 2022 · 7 shares · 25 followers View post →
British Society for Research on Ageing
@BSRAgeing · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. https://t.co/GBHlKmVDlB

Mar 9, 2022 · 2 likes · 2,283 followers View post →
BowTiedBiotech
@BowTiedBiotech · X

The fountain of youth…. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/bI15zeKYBk

Mar 9, 2022 · 1 like · 21,000 followers View post →
John Peacock
@JP12x · X

RT @JoelSercel: @PeterDiamandis Seminal new work published in Nature Aging just hit my inbox today. Yamanaka factor reprograming now PROVEN…

Mar 8, 2022 · 1 share · 36 followers View post →
Kursad Turksen
@kursadturksen · X

#STEMCELL #AGING Published: 07 March 2022 In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice Kristen C. Browder, Pradeep Reddy, …Juan Carlos Izpisua Belmonte Show authors Nature Aging (2022)

Mar 8, 2022 · 230 followers View post →
Joel C. Sercel, PhD
@JoelSercel · X

@PeterDiamandis Seminal new work published in Nature Aging just hit my inbox today. Yamanaka factor reprograming now PROVEN to basically reverse aging in wild type mice. See "In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice". This is HUGE

Mar 8, 2022 · 3 likes · 1 share · 4,110 followers View post →
Ariakas Enoreth
@Aenoreth · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/6A1ftmf2Ju

Mar 8, 2022 · 1,004 followers View post →
Vicen Perez-Garcia
@Vicensella · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/iRzmC7xFIc

Mar 8, 2022 · 7 likes · 1,453 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/sMYsPsaAKF 长期的部分重编程方案改变了小鼠生理衰老过程中与年龄相关的分子变化,使不同组织(例如肾脏和皮肤)恢复活力,效果取决于重编程持续时间。

Mar 8, 2022 · 700 followers View post →
@RegMeD_Brighton
@RegmedB · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/casVfFR0Da

Mar 8, 2022 · 142 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…

Mar 8, 2022 · 7 shares · 245 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/i4v1RoPAM7

Mar 7, 2022 · 1 like · 2,239 followers View post →
LIB
@L_I_B · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/Ywrq10EDVF 読めないんだがこれは結局寿命が伸びるという話なのかそうではないという話なのか

Mar 7, 2022 · 2,155 followers View post →
Jose Luis Andreu
@jlandreu2014 · X

Ah! Quién fuera ratón! In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/mABMWXJjNq

Mar 7, 2022 · 1 like · 8,574 followers View post →
Nutriop Longevity
@nutriop · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice Another paper by @alto... https://t.co/UzZqRDSMXG

Mar 7, 2022 · 80 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice | Nature Aging https://t.co/yxvofSFXMA

Mar 7, 2022 · 3 likes · 4,750 followers View post →
luis hernan graffe
@hernangraffe · X

RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…

Mar 7, 2022 · 7 shares · 3,154 followers View post →
E. P. pinea
@FanONegative · X

RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…

Mar 7, 2022 · 7 shares · 643 followers View post →
BüttnerLab
@ButtnerLab · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice https://t.co/qtxGlHk4sw

Mar 7, 2022 · 4 likes · 913 followers View post →
Will Hubbard
@wbhub · X

RT @agingdoc1: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @alt…

Mar 7, 2022 · 7 shares · 4,118 followers View post →
Agingdoc
@agingdoc1 · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice @NatureAging @altos_labs off to a great start. https://t.co/bi8qedOoIE

Mar 7, 2022 · 19 likes · 7 shares · 41,779 followers View post →
Charles Jourdan Reyes, Ph.D.
@reyes_jourdan · X

RT @ShorterLab: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice: https://t.co/cW3l…

Mar 7, 2022 · 1 share · 621 followers View post →
ShorterLab
@ShorterLab · X

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice: https://t.co/cW3lXRQ43T

Mar 7, 2022 · 3 likes · 1 share · 12,100 followers View post →