Clin Transl Med May 2023 PMID 37132178

Sleep loss potentiates Th17-cell pathogenicity and promotes autoimmune uveitis.

Xiuxing Liu, Yuhan Su, Zhaohao Huang, Jianjie Lv, Chenyang Gu, Zhuang Li, Tianyu Tao, Yidan Liu, Qi Jiang, Runping Duan, Binyao Chen, Rong Ju, Xianggui Wang, Yingfeng Zheng, Wenru Su

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Mentions

Peak: 5 in May 2023

across 2 sources since May 2023

Extended reach

19,974

potential audience

Total likes

Video views

360

Mentions per month

May 2023 – Aug 2023

Where it's discussed

X / Twitter5 posts
YouTube1 videos

AI synopsis

What people are saying

Several posts highlight how sleep deprivation could intensify autoimmune responses, with phrases like 'potentially dangerous implications' reflecting concern and seriousness. The tone combines agreement with scientific significance, showing a balanced interest and moderate engagement via mentions of immune cells and therapeutic strategies, emphasizing the article's importance in health and autoimmune research.

AgreementStrong agreement

Most discussions recognize and support the study's findings that sleep loss worsens autoimmune uveitis through immune cell activity.

InterestModerate interest

There is moderate interest, with some users engaging with details but many simply acknowledging the relevance.

EngagementModerate engagement

Users show some engagement by referencing immune pathways like Th17 cells and potential therapeutic insights, but the overall depth remains moderate.

ImpactHigh impact

The discussions suggest that the publication has substantial implications for understanding autoimmune diseases and could influence future research or treatments.

Abstract in brief

Sleep loss (SL) increases the activity and pathogenicity of immune cells, especially Th17 cells and myeloid cells, which can lead to autoimmune diseases like uveitis, as shown in both human and mouse studies.
SL causes changes in immune cell composition and function, upregulates inflammatory factors like GMCSF, and promotes immune pathways that worsen autoimmune responses and disease severity.
Blocking GMCSF signaling with targeted treatment can reduce the harmful immune effects and mitigate SL-induced aggravation of autoimmune uveitis, highlighting potential therapeutic strategies.

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All mentions

Impact of Sleep Loss on Th17 Cells and Autoimmune Uveitis Risk

Sleep loss increases immune cell activity, especially Th17 cells, promoting autoimmune uveitis. It alters immune composition, upregulates inflammatory factors like GMCSF, and worsens disease severity. Blocking GMCSF can…

Medicine RTCL TV · Aug 25, 2023 360 views

Single Cell papers

@scell_papers · X

Sleep loss potentiates Th17-cell pathogenicity and promotes autoimmune uveitis https://t.co/9JM2U65g02

May 6, 2023 · 11,492 followers View post →

Sleep Research

@SleepResearch_ · X

Sleep loss potentiates Th17-cell pathogenicity and promotes autoimmune uveitis https://t.co/XeSirkuKuL

May 4, 2023 · 7,257 followers View post →

Cytof Manchester

@ManchesterCytof · X

Sleep loss potentiates Th17‐cell pathogenicity and promotes autoimmune uveitis - Liu - 2023 - Clinical and Translational Medicine - Wiley Online Library https://t.co/7u6tyqHZDK #cytofpub

May 3, 2023 · 555 followers View post →

-Seq Papers

@SeqTheWorld · X

Sleep loss potentiates Th17-cell pathogenicity and promotes autoimmune uveitis https://t.co/XbbSdP7Cq1

May 3, 2023 · 6 followers View post →

single cell papers

@sc_papers · X

Sleep loss potentiates Th17-cell pathogenicity and promotes autoimmune uveitis https://t.co/jkt6PkO8kF https://t.co/ucygpxpJwJ

May 3, 2023 · 304 followers View post →