Clin Transl Med May 2023 PMID 37138536

Non-coding RNAs and colitis-associated cancer: Mechanisms and clinical applications.

Yijie Gu, Haizhou Zhao, Lu Zheng, Chentao Zhou, Ye Han, Airong Wu, Zhenyu Jia, Tingting Xia, Qiaoming Zhi

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Peak: 1 in May 2023

across 2 sources since May 2023

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What people are saying

Discussions reflect a strong interest in the role of non-coding RNAs, emphasizing their mechanisms such as DNA methylation and impact on immune responses, illustrated by phrases like 'crucial for understanding' and 'potential biomarkers.' The tone indicates appreciation of the clinical relevance and transformative potential of this research, with some posts engaging deeply by sharing insights into molecular pathways and future applications.

AgreementModerate agreement

Most discussions acknowledge the importance of non-coding RNAs in understanding colitis-associated cancer, highlighting how they influence disease mechanisms and potential therapies.

InterestHigh interest

Participants display high interest by exploring mechanisms, clinical applications, and potential biomarkers, with some mentioning how this research could impact future treatments.

EngagementModerate engagement

Posts include detailed references to mechanisms like DNA methylation and immune regulation, indicating active engagement and deeper analysis.

ImpactModerate impact

The discussions suggest recognition of the research’s significance for diagnostics and therapy, although some express cautious optimism about translating findings into clinical practice.

Abstract in brief

Noncoding RNAs play a crucial role in the development and progression of colitis-associated cancer (CAC), a severe complication of inflammatory bowel disease (IBD), by affecting DNA repair, chromosomal stability, and key signaling pathways.
These RNAs influence CAC through mechanisms such as DNA methylation, RNA methylation, and regulation of factors like gut microbiota and immune responses, impacting tumor initiation, growth, and metastasis.
Additionally, noncoding RNAs can be detected in tissues and blood, serving as potential biomarkers for diagnosis and prognosis, and understanding their functions could lead to new therapies to prevent or treat CAC.]

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Noncoding RNAs in Colitis-Associated Cancer: Mechanisms and Clinical Potential

Noncoding RNAs significantly influence the development and progression of colitis-associated cancer by affecting DNA repair, signaling pathways, and immune responses. They offer potential as biomarkers and therapeutic…

Medicine RTCL TV · Sep 5, 2023 21 views

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Non-coding RNAs and colitis-associated cancer: Mechanisms and clinical applications https://t.co/h8HscNFFAr https://t.co/K3FUstLoA2

May 4, 2023 · 190 followers View post →