Nat Commun May 2023 PMID 37142604

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease.

Jialiu Zeng, Rebeca Acin-Perez, Essam A Assali, Andrew Martin, Alexandra J Brownstein, Anton Petcherski, Lucía Fernández-Del-Rio, Ruiqing Xiao, Chih Hung Lo, Michaël Shum, Marc Liesa, Xue Han, Orian S Shirihai, Mark W Grinstaff

Mentions

23
Peak: 19 in May 2023
across 3 sources since May 2023

Extended reach

273,923
potential audience

Total likes

69

Video views

30

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter20 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions show high enthusiasm, with phrases like 'excited about our work' and 'promising new therapy,' indicating strong support and focus on the research's potential impact. The tone emphasizes significance and innovation, especially regarding nanotechnology and autophagy, reflecting deep engagement with the study's approach and implications.

AgreementStrong agreement

Most discussions express strong support and enthusiasm for the research findings and their potential implications.

InterestHigh interest

The posts demonstrate high interest, highlighting the significance of the study in advancing NAFLD treatments and nanotechnology applications.

EngagementModerate engagement

Comments reference specific aspects such as the method of restoring lysosomal acidity and the translation to therapy, indicating active engagement.

ImpactHigh impact

Participants believe the research could be transformative for NAFLD treatment and nanotechnology use in medicine.

Abstract in brief

  • NAFLD is the most common liver disease and is caused by high free fatty acids that disrupt lysosomal acidification and autophagy.
  • Researchers developed biodegradable acid-activating nanoparticles (acNPs) that specifically target and restore lysosomal acidity in liver cells, improving autophagy and mitochondrial function.
  • In mouse models with NAFLD, treatment with acNPs reversed liver fat buildup and metabolic issues, suggesting these nanoparticles could be a promising new therapy for NAFLD.

Top posts

Most liked on X and Bluesky
Lysosome Articles
@LysosomeJC · X

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. https://t.co/BUHgQqVDM5

May 5, 2023 · 48 likes · 18 shares · 2,039 followers View post →
Mark G.
@Grinstaff · X

Excited about our work being published in @NatureComms - @OrianShirihai @JialiuZeng @xuehan #nanotechnology applications in #NAFLD treatment https://t.co/CN7HgGNmgC #liverdisease #autophagy @BU_Tweets https://t.co/pU1XRKR8li https://t.co/ofKRJDorIc

May 9, 2023 · 20 likes · 2 shares · 1,790 followers View post →
BU Chemistry
@BUChemistry · X

Check out Professor Mark Grinstaff's recently co-authored a paper in Nature Communications, "Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease." https://t.co/iyskuYUUgj

Jun 2, 2023 · 1 like · 2,570 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 253,974 followers View post →
Marina García Macia
@Juanaloca2002 · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 2,810 followers View post →
BU Chemistry
@BUChemistry · X

RT @Grinstaff: Excited about our work being published in @NatureComms - @OrianShirihai @JialiuZeng @xuehan #nanotechnology applications in…

May 10, 2023 · 2 shares · 2,570 followers View post →

All mentions

BU Chemistry
@BUChemistry · X

Check out Professor Mark Grinstaff's recently co-authored a paper in Nature Communications, "Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease." https://t.co/iyskuYUUgj

Jun 2, 2023 · 1 like · 2,570 followers View post →
Boston University Biomedical Engineering
@BostonU_BME · X

RT @Grinstaff: Excited about our work being published in @NatureComms - @OrianShirihai @JialiuZeng @xuehan #nanotechnology applications in…

May 12, 2023 · 2 shares · 1,911 followers View post →
BU Chemistry
@BUChemistry · X

RT @Grinstaff: Excited about our work being published in @NatureComms - @OrianShirihai @JialiuZeng @xuehan #nanotechnology applications in…

May 10, 2023 · 2 shares · 2,570 followers View post →
Mark G.
@Grinstaff · X

Excited about our work being published in @NatureComms - @OrianShirihai @JialiuZeng @xuehan #nanotechnology applications in #NAFLD treatment https://t.co/CN7HgGNmgC #liverdisease #autophagy @BU_Tweets https://t.co/pU1XRKR8li https://t.co/ofKRJDorIc

May 9, 2023 · 20 likes · 2 shares · 1,790 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Nature Communications paper "Restoration of lysosomal acidification rescues aut…" (https://t.co/QDKa7sNXc0). We appreciate the author's support of reproducibility. #RRID #methodsmatter

May 7, 2023 · 161 followers View post →
Prof.Thomas Pulinilkunnil
@tpulinil · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 6, 2023 · 18 shares · 1,084 followers View post →
Aby Anand
@AbyAnand1 · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 6, 2023 · 18 shares · 212 followers View post →
Luiz Romeiro
@lasromeiro · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 183 followers View post →
Marina García Macia
@Juanaloca2002 · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 2,810 followers View post →
Attila Çakmak
@AttilaCakmak · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 98 followers View post →
Asila Al Mushaifri
@almuhalb97 · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 827 followers View post →
El Chepo Gwapo.BTC
@DrGwapoLeon · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 679 followers View post →
Darra Alfiyah
@DarraAlfiyah · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 37 followers View post →
Tasleem Arif
@tashu100 · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 87 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 253,974 followers View post →
Dawid Artur Jaślan,
@ArturJalan · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 115 followers View post →
Phenomics
@Phenomics_J · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 1,527 followers View post →
もろふし
@morofushi1230 · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 368 followers View post →
Mónica Muñoz
@soymonivega · X

RT @LysosomeJC: Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. h…

May 5, 2023 · 18 shares · 299 followers View post →
Lysosome Articles
@LysosomeJC · X

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. https://t.co/BUHgQqVDM5

May 5, 2023 · 48 likes · 18 shares · 2,039 followers View post →