Mol Biomed May 2023 PMID 37142850

Targeting bromodomain-containing proteins: research advances of drug discovery.

Zhaoping Pan, Yuxi Zhao, Xiaoyun Wang, Xin Xie, Mingxia Liu, Kaiyao Zhang, Lian Wang, Ding Bai, Leonard J Foster, Rui Shu, Gu He

Mentions

3
Peak: 2 in May 2023
across 2 sources since May 2023

Extended reach

183
potential audience

Total likes

0

Video views

17

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions show strong interest and support for the progress in targeting bromodomain proteins, with posts mentioning the promising inhibitors and research challenges. Words like 'advances', 'future directions', and 'potential' reflect optimism and recognition of the research's importance.

AgreementModerate agreement

Most discussions express support or positive acknowledgment of the research advances, indicating general agreement with the article's significance.

InterestHigh interest

The posts demonstrate high interest by highlighting new drug developments and future research directions, showing engagement with the subject matter.

EngagementModerate engagement

Users actively discuss implications, such as the potential for targeted therapies, indicating a moderate level of engagement.

ImpactModerate impact

The discussions suggest that the research could influence future drug development and understanding of disease mechanisms, though this is more aspirational than confirmed.

Abstract in brief

  • Bromodomain (BD) is a key protein module found in 46 different proteins that can bind to acetylated lysine, playing crucial roles in gene regulation and cellular processes, but is also linked to various diseases like cancer and inflammation.
  • Recent research has focused on developing drugs that inhibit or downregulate these bromodomain-containing proteins (BCPs), with many promising inhibitors already in clinical trials.
  • This paper reviews the progress in designing BCP inhibitors, outlines challenges faced in drug development, and suggests future research paths to improve the efficacy and safety of these potential treatments.

Top posts

Most liked on X and Bluesky
Cardio-Targets
@CardioTargets · X

Targeting bromodomain-containing proteins: research advances of drug discovery https://t.co/1Uj0CemDOI

May 5, 2023 · 153 followers View post →
GK
@GK27726828 · X

Targeting bromodomain-containing proteins: research advances of drug discovery https://t.co/wFJ065PSvc https://t.co/5LYHeOVMKB

May 5, 2023 · 14 followers View post →

All mentions

GK
@GK27726828 · X

Targeting bromodomain-containing proteins: research advances of drug discovery https://t.co/wFJ065PSvc https://t.co/5LYHeOVMKB

May 5, 2023 · 14 followers View post →
Cardio-Targets
@CardioTargets · X

Targeting bromodomain-containing proteins: research advances of drug discovery https://t.co/1Uj0CemDOI

May 5, 2023 · 153 followers View post →