Nat Commun May 2023 PMID 37147288

Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation.

Yafeng Li, Jessica S Hook, Qing Ding, Xue Xiao, Stephen S Chung, Marcel Mettlen, Lin Xu, Jessica G Moreland, Michalis Agathocleous

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Peak: 4 in May 2023

across 2 sources since May 2023

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May 2023 – Aug 2023

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What people are saying

The overall tone indicates that the community finds the metabolic mechanisms, like GAPDH's role, intriguing and potentially impactful, such as mentions of 'neutrophil function' and the 'metabolic disruption,’ with some users emphasizing the importance of these findings for understanding severe COVID-19 and describing the research as 'a step forward' in immune studies.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, with some explicitly supporting the idea that GAPDH plays a key role in neutrophil regulation in severe COVID-19.

InterestHigh interest

Participants show high curiosity, likely due to the connection between neutrophil metabolism and COVID-19 severity, evidenced by comments highlighting the novelty of metabolic pathways involved.

EngagementModerate engagement

There is a moderate level of exploration, with some users referencing specific aspects like enzyme activity and immune cell dysfunction, but few detailed technical debates.

ImpactModerate impact

The discussions suggest recognition of the research’s potential to influence future treatment strategies and deepen understanding of immune responses, though not unanimously viewed as groundbreaking.

Abstract in brief

Severe COVID-19 leads to changes in innate immune cells, particularly neutrophils, showing altered metabolism compared to mild cases and healthy individuals.
Metabolomic analysis revealed disruptions in amino acids, redox, and carbon metabolism linked to decreased activity of the glycolytic enzyme GAPDH.
Inhibiting GAPDH affects neutrophil functions such as glycolysis and influences extracellular trap formation, suggesting that these metabolic changes contribute to neutrophil dysfunction in severe COVID-19 cases.

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All mentions

GAPDH's Role in Neutrophil Dysfunction in Severe COVID-19

Severe COVID-19 causes metabolic changes in neutrophils, notably decreasing GAPDH activity, which impacts their immune functions and trap formation, contributing to disease severity.

STEM RTCL TV · Aug 20, 2023 21 views

Stavros Giaglis, PhD

@StavrosGiaglis · X

Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation | Nature Communications https://t.co/Evw4RINCJJ

May 9, 2023 · 359 followers View post →

pathdoc3

@pathdoc3 · X

May 8, 2023 · 1 like · 1,234 followers View post →

LungOmics

@LungOmics · X

Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation https://t.co/POSrn8Vdku https://t.co/h2ST6kWtov

May 8, 2023 · 39 followers View post →

Metabolomics Papers

@Metabbot · X

Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation. Nat Commun #metabolomics https://t.co/Rs4rBpH7n7

May 6, 2023 · 5 likes · 1,489 followers View post →