J Neuroinflammation May 2023 PMID 37147668

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer's disease.

Yanaika S Hok-A-Hin, Marta Del Campo, Walter A Boiten, Erik Stoops, Melanie Vanhooren, Afina W Lemstra, Wiesje M van der Flier, Charlotte E Teunissen

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Peak: 6 in May 2023

across 3 sources since May 2023

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Users emphasize the importance of biomarkers like MIF, sTREM1, and sTREM2 in tracking AD, often discussing their levels at various disease stages and their correlation with other clinical measures. The use of terms like 'significant' and 'potential' reflects a mixture of optimism and cautious interest, driven by the article's detailed profiling of inflammatory markers.

AgreementModerate agreement

Most discussions recognize the significance of the findings, with some explicitly highlighting the potential of these biomarkers for understanding AD progression.

InterestHigh interest

The topic appears highly engaging, with users expressing curiosity about the implications of biomarker dynamics in Alzheimer's disease.

EngagementModerate engagement

Posts show moderate engagement by referencing specific biomarkers and their roles, indicating thoughtful consideration beyond surface-level reactions.

ImpactModerate impact

While some comments hint at the potential clinical impact of these findings, the general tone suggests a developing interest rather than definitive conclusions.

Abstract in brief

The study found that neuroinflammatory biomarkers like MIF, sTREM1, and sTREM2 show significant changes in their levels across different stages of Alzheimer's disease (AD) and related conditions, indicating their potential as fluid biomarkers for tracking disease progression.
MIF and sTREM1 levels increase in conditions such as mild cognitive impairment (MCI), AD, and dementia with Lewy bodies (DLB), while sTREM2 levels are notably elevated only in MCI, highlighting their specific roles at different disease stages.
These inflammatory markers are strongly correlated with other CSF biomarkers of AD, such as pTau, and with clinical measures like MMSE scores, suggesting they could be useful for monitoring neuroinflammatory responses and disease severity in AD.]

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Dynamic Neuroinflammatory Biomarkers in Alzheimer's Disease Progression

Neuroinflammatory biomarkers like MIF, sTREM1, and sTREM2 exhibit significant changes across Alzheimer's disease stages, indicating their potential as fluid biomarkers for tracking disease progression and severity.

Social RTCL TV · Aug 28, 2023 17 views

ADx NeuroSciences

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May 12, 2023 · 5 likes · 82 followers View post →

Shweta Puntambekar

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RT @Aenoreth: Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease https://t.co…

May 8, 2023 · 3 shares · 237 followers View post →

Tharick Pascoal

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RT @Aenoreth: Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease https://t.co…

May 8, 2023 · 3 shares · 1,652 followers View post →

ZZneuroscience

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RT @Aenoreth: Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease https://t.co…

May 8, 2023 · 3 shares · 3 followers View post →

ZZneuroscience

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Ariakas Enoreth

@Aenoreth · X

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease https://t.co/1HnIfvtuRa

May 8, 2023 · 14 likes · 3 shares · 1,009 followers View post →

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer's disease.

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Dynamic Neuroinflammatory Biomarkers in Alzheimer's Disease Progression