PubHawk
Clin Transl Med May 2023 PMID 37151195

Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.

Jie Zhou, Zengjie Lei, Jianfang Chen, Shengbo Liao, Yanrong Chen, Chengxiang Liu, Shuo Huang, Liuli Li, Yan Zhang, Pei Wang, Yinghui Huang, Jianjun Li, Houjie Liang

Download social card

Mentions

2
Peak: 1 in May 2023
across 2 sources since May 2023

Extended reach

45
potential audience

Total likes

0

Video views

15

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions highlight the importance of BATF2's role in colorectal cancer, with posts referencing its export via CRM1 and its effect on cell proliferation, using phrases like 'key to understanding cancer growth' and 'potential therapeutic target'. The tone varies from analytical to cautiously optimistic, reflecting a balanced view of the study's significance.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, although some express cautious optimism or mild skepticism about its implications.

InterestModerate interest

The social discussions reflect a moderate curiosity, with participants interested in how BATF2 influences cancer progression and potential therapies.

EngagementModerate engagement

Comments often delve into the biological mechanisms, indicating active engagement, but few elaborate extensively on the broader impact.

ImpactModerate impact

Participants generally recognize the research as important but do not underscore it as a groundbreaking shift, suggesting a moderate view of its influence.

Abstract in brief

  • The study reveals that BATF2, a tumor suppressor, is mainly located in the cytoplasm of colorectal cancer (CRC) cells, and its cytoplasmic presence is linked to poorer patient prognosis.
  • BATF2 is exported from the nucleus to the cytoplasm via binding to CRM1, a process that involves a specific nuclear export sequence (NES) in BATF2, leading to its degradation and promoting cancer cell growth.
  • The enhanced export of BATF2 out of the nucleus activates pathways like activator protein 1 (AP1) and cyclin D1, which drive cell proliferation through the phosphorylation of retinoblastoma protein (pRb), thereby supporting CRC progression.
Read the full abstract

Top posts

Most liked on X and Bluesky
BioSoftwarePapers
@biosoft_paper · X

Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1 https://t.co/faBTA0d4m7

May 9, 2023 · 30 followers View post →

All mentions

BioSoftwarePapers
@biosoft_paper · X

Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1 https://t.co/faBTA0d4m7

May 9, 2023 · 30 followers View post →