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Nat Metab May 2023 PMID 37157031

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation.

Jinzhong Tian, Chong Li, Zhixiang Dong, Yunpeng Yang, Jing Xing, Peijun Yu, Ying Xin, Fengmei Xu, Lianwei Wang, Yahui Mu, Xiangyang Guo, Qiang Sun, Guoping Zhao, Yang Gu, Guijun Qin

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Mentions

31
Peak: 21 in May 2023
across 3 sources since May 2023

Extended reach

266,621
potential audience

Total likes

42

Video views

9

Mentions per month

May 2023 – Nov 2024

Where it's discussed

  • X / Twitter27 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The overall discussions reflect strong interest and recognition of the research's significance, with phrases such as 'identifies bacteria linked to resistance' and 'potential impact on treatment,' indicating that users appreciate the scientific and medical implications. The tone and choice of words emphasize both curiosity and the importance of understanding gut microbiota's influence on medication efficacy.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, especially highlighting the role of gut bacteria like Klebsiella grimontii in drug resistance, indicating a general consensus of support.

InterestHigh interest

Posts demonstrate high interest, frequently emphasizing the potential implications for diabetes treatment and personalized medicine through phrases like 'important discovery' and 'significant findings.'

EngagementModerate engagement

Users show moderate engagement by referencing specific bacteria and the mechanisms of drug degradation, suggesting a deeper level of consideration beyond superficial mentions.

ImpactHigh impact

The discussions suggest the findings could have substantial effects on how antidiabetic treatments are viewed and adjusted, with comments implying potential shifts in clinical approaches and understanding of drug resistance.

Abstract in brief

  • Drugs like acarbose can be affected by gut bacteria, influencing how well they work in personalized treatment.
  • Researchers discovered a specific bacterium, Klebsiella grimontii TD1, that breaks down acarbose and is linked to resistance in patients.
  • Findings suggest that the presence of K. grimontii TD1 may decrease the drug's effectiveness, highlighting a potential issue of drug resistance not just seen with antibiotics.
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Top posts

Most liked on X and Bluesky
Host-Microbe Interactions
@HostMicrobeLit · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Identifies an acarbose-degrading bacteria (Klebsiella grimontii), whose presence is associated with acarbose resistance in patients https://t.co/uB76l7xMu3

May 12, 2023 · 18 likes · 8 shares · 3,474 followers View post →
Nature Metabolism
@NatMetabolism · X

Online now! Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.co/GqBqGkz9kZ https://t.co/kBtY1Owz8v

May 8, 2023 · 9 likes · 4 shares · 79,171 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

AOP #ResearchHighlight: inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation (£) https://t.co/IoY9ZONHk1 #diabetes https://t.co/dwiLpkAusI

Jun 2, 2023 · 8 likes · 4 shares · 35,350 followers View post →
Agingdoc
@agingdoc1 · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.co/qm7pnwQVCf @NatMetabolism https://t.co/yrDV0vhAn3

May 8, 2023 · 2 likes · 41,347 followers View post →
Microbiome Articles
@microbe_article · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation. - Tian J et al. - https://t.co/d2UmmT5c03 #microbiome

May 9, 2023 · 2 likes · 1 share · 7,153 followers View post →
Sáfárné Hatrágyi Henrietta
@HatragyiSafarne · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation.

May 9, 2023 · 1 like · 1 share · 490 followers View post →

All mentions

Sáfárné Hatrágyi Henrietta
@HatragyiSafarne · X

RT @HatragyiSafarne: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation.

Nov 10, 2024 · 1 share · 490 followers View post →
ZYRAH
@zyrahsamar · X

RT @NatureRevEndo: AOP #ResearchHighlight: inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradatio…

Jun 4, 2023 · 4 shares · 195 followers View post →
Shreya Ghosh
@shrez07 · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation | Nature Metabolism https://t.co/LGLjTCAnzp

Jun 3, 2023 · 145 followers View post →
ARYAN®
@gladeolie · X

RT @NatureRevEndo: AOP #ResearchHighlight: inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradatio…

Jun 2, 2023 · 4 shares · 1,492 followers View post →
Wendy Phua, PhD
@DrWendyPhua · X

RT @NatureRevEndo: AOP #ResearchHighlight: inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradatio…

Jun 2, 2023 · 4 shares · 99 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

AOP #ResearchHighlight: inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation (£) https://t.co/IoY9ZONHk1 #diabetes https://t.co/dwiLpkAusI

Jun 2, 2023 · 8 likes · 4 shares · 35,350 followers View post →
Saravanan Devendran
@SaravananDeven4 · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 14, 2023 · 8 shares · 62 followers View post →
Chieh-Jen Cheng
@ChiehJenCheng3 · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 14, 2023 · 8 shares · 32 followers View post →
Maruhen Datsch Silveira
@MaruhenSilveira · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 13, 2023 · 8 shares · 182 followers View post →
Arnau Vich Vila
@arnauvich · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 13, 2023 · 8 shares · 592 followers View post →
Adrian Brink
@ABpreservation · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 13, 2023 · 8 shares · 2,142 followers View post →
Klebsiella Club
@KlebClub · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 12, 2023 · 8 shares · 738 followers View post →
Salahuddin Khan
@salahwormsnbugs · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 12, 2023 · 8 shares · 261 followers View post →
Fadhilah
@AraniyF · X

RT @HostMicrobeLit: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Iden…

May 12, 2023 · 8 shares · 233 followers View post →
Host-Microbe Interactions
@HostMicrobeLit · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation @NatMetabolism Identifies an acarbose-degrading bacteria (Klebsiella grimontii), whose presence is associated with acarbose resistance in patients https://t.co/uB76l7xMu3

May 12, 2023 · 18 likes · 8 shares · 3,474 followers View post →
Conscious Tone
@ToneConscious · X

RT @NatMetabolism: Online now! Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.…

May 12, 2023 · 4 shares · 55 followers View post →
Maryam
@Maryam__Sayadi · X

RT @NatMetabolism: Online now! Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.…

May 9, 2023 · 4 shares · 69 followers View post →
Transcriptomes
@transcriptomes · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degrada... https://t.co/lJhFvE5nVn

May 9, 2023 · 1,808 followers View post →
Phenomics
@Phenomics_J · X

RT @microbe_article: Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation. - Tian J et al. - h…

May 9, 2023 · 1 share · 1,527 followers View post →
Rene Sugar
@renesugar · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.co/UajR5VsGR1

May 9, 2023 · 3,953 followers View post →
Sáfárné Hatrágyi Henrietta
@HatragyiSafarne · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation.

May 9, 2023 · 1 like · 1 share · 490 followers View post →
INTERNAL MEDICINE
@medicinterna · X

RT @NatMetabolism: Online now! Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.…

May 9, 2023 · 4 shares · 2,455 followers View post →
Nature Metabolism
@NatMetabolism · X

RT @NatMetabolism: Online now! Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.…

May 9, 2023 · 4 shares · 79,171 followers View post →
Microbiome Articles
@microbe_article · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation. - Tian J et al. - https://t.co/d2UmmT5c03 #microbiome

May 9, 2023 · 2 likes · 1 share · 7,153 followers View post →
Metagenomics Papers
@metagenomic_lit · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.co/1UYWKfrJya

May 9, 2023 · 3,702 followers View post →
Agingdoc
@agingdoc1 · X

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.co/qm7pnwQVCf @NatMetabolism https://t.co/yrDV0vhAn3

May 8, 2023 · 2 likes · 41,347 followers View post →
Nature Metabolism
@NatMetabolism · X

Online now! Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation https://t.co/GqBqGkz9kZ https://t.co/kBtY1Owz8v

May 8, 2023 · 9 likes · 4 shares · 79,171 followers View post →