Commun Med (Lond) May 2023 PMID 37165152

Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures for Parkinson's disease.

Marco Hadisurya, Li Li, Kananart Kuwaranancharoen, Xiaofeng Wu, Zheng-Chi Lee, Roy N Alcalay, Shalini Padmanabhan, W Andy Tao, Anton Iliuk

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Mentions

Peak: 3 in May 2023

across 2 sources since May 2023

Extended reach

66,672

potential audience

Total likes

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Mentions per month

May 2023 – Sep 2023

Where it's discussed

X / Twitter6 posts
YouTube1 videos

AI synopsis

What people are saying

The group emphasizes the innovative use of urinary extracellular vesicles as a non-invasive diagnostic tool, with comments referencing proteomics techniques and potential for early detection. Words like 'promising,' 'significant,' and phrases about new diagnostic opportunities show enthusiasm and recognition of the study's importance.

AgreementModerate agreement

Most discussions acknowledge the study's findings as promising and significant for Parkinson's diagnosis, indicating moderate agreement.

InterestHigh interest

Participants show high interest, likely due to the innovative non-invasive approach and potential clinical impact.

EngagementModerate engagement

Comments include references to the methods (proteomics, biomarkers) and implications, suggesting thoughtful engagement.

ImpactModerate impact

The discussions highlight the potential for early detection and diagnostic advancements, implying a considerable impact in the field.

Abstract in brief

This study focuses on discovering potential early diagnostic biomarkers for Parkinson's Disease (PD) by analyzing proteins and phosphoproteins in urinary extracellular vesicles (EVs) from different groups, including healthy individuals, those with genetic mutations linked to PD, and PD patients.
Using advanced proteomics techniques like mass spectrometry, researchers identified thousands of unique proteins and phosphoproteins, finding several that are elevated in PD patients and involved in important disease-related pathways such as autophagy, neuroinflammation, and neuronal death.
The study established a panel of candidate biomarkers, validated some through targeted testing methods, and demonstrated that analyzing EV contents in urine is a promising, non-invasive approach for early PD detection and potentially other diseases.]

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All mentions

Urinary Vesicle Proteomics for Parkinson's Disease Biomarkers

This study explores early diagnostic biomarkers for Parkinson's Disease by analyzing proteins in urinary extracellular vesicles, using advanced mass spectrometry to identify disease-related signatures for improved…

Medicine RTCL TV · Sep 4, 2023 11 views

Marco Hadisurya PhD @ Purdue

@HadisuryaMarco · X

RT @InnovationFixer: Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatur…

Jun 11, 2023 · 2 shares · 94 followers View post →

The Science of Parkinson's

@ScienceofPD · X

RT @InnovationFixer: Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatur…

Jun 11, 2023 · 2 shares · 10,908 followers View post →

Kevin McFarthing

@InnovationFixer · X

Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures for Parkinson’s disease | Communications Medicine https://t.co/LZMzWPGyvO

Jun 11, 2023 · 10 likes · 2 shares · 8,844 followers View post →

Marco Hadisurya PhD @ Purdue

@HadisuryaMarco · X

RT @NatRevNeurol: Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures…

May 11, 2023 · 1 share · 94 followers View post →

Nat Rev Neurology

@NatRevNeurol · X

Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures for Parkinson’s disease https://t.co/NbAKhFWfGE

May 11, 2023 · 5 likes · 1 share · 46,493 followers View post →

Oncology & Machine Learning

@MlOncology · X

Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures for Parkinson's disease https://t.co/p4gBJQ9z4l

May 11, 2023 · 213 followers View post →