Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べたら閾値が哺乳類よりも低く、アンキリンリピートが温度の閾値の差異に関わるかもというお話 https://t.co/Y6Xu4Kfprb
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1.
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May 2023 – Aug 2023Where it's discussed
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X / Twitter13 posts
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News6 articles
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YouTube1 videos
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What people are saying
The discussions highlight the importance of the mutations' role in thermosensation, with posts mentioning how they 'drastically change' the threshold temperature, emphasizing their significance. The tone suggests that users find the research notable for understanding adaptation mechanisms, although the overall excitement is measured rather than sensational.
Most discussions recognize the significance of the research, indicating general agreement that the findings are relevant.
Comments suggest moderate curiosity, with some posts emphasizing the importance of understanding temperature sensitivity in TRPV1.
Posts reference specific aspects of the mutations and their effects, showing a degree of deep engagement with the scientific content.
The collective tone hints at the potential relevance of these findings for broader biological understanding and adaptation, indicating a moderate perceived impact.
Abstract in brief
- The study investigates how two specific mutations in the ANK1 region of TRPV1, a heat-sensitive ion channel, significantly lower its threshold temperature for activation in tailed amphibians, which prefer cooler environments, compared to rats.
- These amino acid differences (Gln, LeuVal in amphibians versus Arg, Lys in rats) are conserved among tailed amphibians and are shown to increase heat activation when substituted into TRPV1, highlighting their role in adapting to cooler habitats.
- The findings suggest that these mutations in TRPV1 enable tailed amphibians to better sense lower temperatures, likely contributing to their habitat preferences and thermosensory adaptation.]
Top posts
Most liked on X and BlueskyTwo single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 | Nature Communications https://t.co/7JvwkrFtDT
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 https://t.co/uOUjhQon9l
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
All mentions
Impact of Single-Point Mutations on TRPV1 Heat Activation Thresholds
This study investigates how two specific mutations in the ANK1 region of TRPV1 lower its activation temperature, aiding thermosensory adaptation in tailed amphibians to cooler environments.
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 | Nature Communications https://t.co/7JvwkrFtDT
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 | Nature Communications https://t.co/rmkEyxj8Ub
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 https://t.co/uOUjhQon9l
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べたら閾値が哺乳類よりも低く、アンキリンリピートが温度の閾値の差異に関わるかもというお話 https://t.co/Y6Xu4Kfprb