Nat Commun May 2023 PMID 37169739

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1.

Shogo Hori, Michihiro Tateyama, Tsuyoshi Shirai, Yoshihiro Kubo, Osamu Saitoh

Mentions

20
Peak: 13 in May 2023
across 3 sources since May 2023

Extended reach

18,103
potential audience

Total likes

35

Video views

27

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter13 posts
  • News6 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions highlight the importance of the mutations' role in thermosensation, with posts mentioning how they 'drastically change' the threshold temperature, emphasizing their significance. The tone suggests that users find the research notable for understanding adaptation mechanisms, although the overall excitement is measured rather than sensational.

AgreementModerate agreement

Most discussions recognize the significance of the research, indicating general agreement that the findings are relevant.

InterestModerate interest

Comments suggest moderate curiosity, with some posts emphasizing the importance of understanding temperature sensitivity in TRPV1.

EngagementModerate engagement

Posts reference specific aspects of the mutations and their effects, showing a degree of deep engagement with the scientific content.

ImpactModerate impact

The collective tone hints at the potential relevance of these findings for broader biological understanding and adaptation, indicating a moderate perceived impact.

Abstract in brief

  • The study investigates how two specific mutations in the ANK1 region of TRPV1, a heat-sensitive ion channel, significantly lower its threshold temperature for activation in tailed amphibians, which prefer cooler environments, compared to rats.
  • These amino acid differences (Gln, LeuVal in amphibians versus Arg, Lys in rats) are conserved among tailed amphibians and are shown to increase heat activation when substituted into TRPV1, highlighting their role in adapting to cooler habitats.
  • The findings suggest that these mutations in TRPV1 enable tailed amphibians to better sense lower temperatures, likely contributing to their habitat preferences and thermosensory adaptation.]

Top posts

Most liked on X and Bluesky
Kato
@oxkawaka · X

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べたら閾値が哺乳類よりも低く、アンキリンリピートが温度の閾値の差異に関わるかもというお話 https://t.co/Y6Xu4Kfprb

May 11, 2023 · 32 likes · 10 shares · 5,816 followers View post →
ぜのぱす(初代_凍結から快復)
@Xenopus007 · X

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 | Nature Communications https://t.co/7JvwkrFtDT

May 11, 2023 · 2 likes · 854 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 https://t.co/uOUjhQon9l

May 11, 2023 · 1 like · 1,956 followers View post →
Masa-aki Yoshida
@yoshidamasaaki · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 2,835 followers View post →
Hikari Yoshitane
@HYtane · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 2,425 followers View post →
とよけらとぷす
@rex_toyo · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 2,152 followers View post →

All mentions

sacha salphati
@SSalphati · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 16, 2023 · 10 shares · 25 followers View post →
Zy
@Zy_shintamhouse · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 15, 2023 · 10 shares · 192 followers View post →
とよけらとぷす
@rex_toyo · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 2,152 followers View post →
ぜのぱす(初代_凍結から快復)
@Xenopus007 · X

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 | Nature Communications https://t.co/7JvwkrFtDT

May 11, 2023 · 2 likes · 854 followers View post →
やもり
@yamori_ju · X

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 | Nature Communications https://t.co/rmkEyxj8Ub

May 11, 2023 · 384 followers View post →
ぜのぱす(初代_凍結から快復)
@Xenopus007 · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 854 followers View post →
Masa-aki Yoshida
@yoshidamasaaki · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 2,835 followers View post →
Itomaki
@Itomaki_86 · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 319 followers View post →
shimoT
@tada02270411 · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 13 followers View post →
Hikari Yoshitane
@HYtane · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 2,425 followers View post →
Keizo Nishikawa
@ihaveapenpai · X

RT @oxkawaka: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べ…

May 11, 2023 · 10 shares · 51 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 https://t.co/uOUjhQon9l

May 11, 2023 · 1 like · 1,956 followers View post →
Kato
@oxkawaka · X

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1 涼しい環境に生きる両生類のTRPV1を調べたら閾値が哺乳類よりも低く、アンキリンリピートが温度の閾値の差異に関わるかもというお話 https://t.co/Y6Xu4Kfprb

May 11, 2023 · 32 likes · 10 shares · 5,816 followers View post →