Nat Commun May 2023 PMID 37169749

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment.

Marius Schwabenland, Omar Mossad, Annika Sievert, Adam G Peres, Elena Ringel, Sebastian Baasch, Julia Kolter, Giulia Cascone, Nikolaos Dokalis, Andreas Vlachos, Zsolt Ruzsics, Philipp Henneke, Marco Prinz, Thomas Blank

Mentions

11
Peak: 6 in May 2023
across 3 sources since May 2023

Extended reach

5,260
potential audience

Total likes

2

Video views

20

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter6 posts
  • News4 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a balanced recognition of the study's importance, with examples such as mentions of their focus on microglial cells and behavioral outcomes, indicating that posters are engaging with the core mechanisms and implications, although often with brief comments that show awareness rather than detailed critique.

AgreementModerate agreement

Most discussions acknowledge the importance of the findings, highlighting the sex-specific effects and biological implications.

InterestModerate interest

Participants demonstrate moderate curiosity, often referencing the research and its potential relevance to neurodevelopmental disorders.

EngagementModerate engagement

Posts show some depth by mentioning specific mechanisms like microglial reprogramming and behavioral impacts, though with limited elaboration.

ImpactModerate impact

The discussion points to the study's significance for understanding sex differences in neuroimmune responses, suggesting a notable scientific and medical influence.

Abstract in brief

  • Research suggests that early life immune activation may contribute to sex biases in central nervous system disorders, particularly after viral infections.
  • In a study with neonatal male and female mice, only the males exhibited behavioral deficits and immune response changes after mimicking a viral infection.
  • These changes included increased T cell infiltration in the brain and abnormal microglial activity, leading to significant synapse loss, highlighting vulnerabilities in male adolescents after early infections.

Top posts

Most liked on X and Bluesky
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/TrDo9mQ1Hp

May 11, 2023 · 1 like · 1,956 followers View post →
Lucassen lab University of Amsterdam
@LucassenPJ · X

Neonatal immune challenge poses a sex-specific risk for epigenetic #microglia reprogramming and behavioral impairment, Prinz & Blank labs @NatureComms https://t.co/CzTt76gx45

May 16, 2023 · 1 like · 1,472 followers View post →
Phage Papers
@Phage_Papers · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/2kEzKcC5oH

May 12, 2023 · 647 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment" https://t.co/ZHQjUet5xC

May 12, 2023 · 620 followers View post →
SynapsePapers
@SynapsePapers · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/60SRkqx2KR

May 12, 2023 · 474 followers View post →
minnlab_litbot
@MLitbot · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/wauXTEMRX4 https://t.co/zmrzgnwBXn

May 12, 2023 · 72 followers View post →

All mentions

Lucassen lab University of Amsterdam
@LucassenPJ · X

Neonatal immune challenge poses a sex-specific risk for epigenetic #microglia reprogramming and behavioral impairment, Prinz & Blank labs @NatureComms https://t.co/CzTt76gx45

May 16, 2023 · 1 like · 1,472 followers View post →
SynapsePapers
@SynapsePapers · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/60SRkqx2KR

May 12, 2023 · 474 followers View post →
minnlab_litbot
@MLitbot · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/wauXTEMRX4 https://t.co/zmrzgnwBXn

May 12, 2023 · 72 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment" https://t.co/ZHQjUet5xC

May 12, 2023 · 620 followers View post →
Phage Papers
@Phage_Papers · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/2kEzKcC5oH

May 12, 2023 · 647 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment https://t.co/TrDo9mQ1Hp

May 11, 2023 · 1 like · 1,956 followers View post →