PubHawk
BMC Med May 2023 PMID 37170220

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study.

Shu Xu, Xiaozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma, Liyuan Xiang, Lianmin Chen, Yijun Zhu, Ce Tang, Arno R Bourgonje, Miaoxin Li, Yao He, Zhirong Zeng, Shixian Hu

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Mentions

22
Peak: 20 in May 2023
across 2 sources since May 2023

Extended reach

31,749
potential audience

Total likes

19

Video views

81

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter21 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects strong agreement and recognition of the study’s significance, as seen in phrases like 'statistical evidence of causality' and 'trigger Crohn's disease,' which convey support and interest. The use of words such as 'provide,' 'support,' and 'trigger' highlight engagement, while references to the potential impact of understanding disease mechanisms suggest high perceived influence.

AgreementStrong agreement

Most discussions express strong support for the findings and emphasize the importance of the research, showing near-unanimous agreement.

InterestModerate interest

Posts demonstrate moderate interest, with many highlighting the significance of the study but not delving deeply into technical details.

EngagementModerate engagement

Several discussions mention the mechanisms investigated, indicating active engagement, but overall engagement remains moderate.

ImpactHigh impact

The tone suggests the research is viewed as highly impactful, with posts referring to the potential for new interventions and understanding Crohn's disease.

Abstract in brief

  • The study investigates how oxidative stress (OS) genes, DNA methylation, and gut microbiota interactions contribute to Crohn's disease (CD) using a multiomics Mendelian randomization approach, aiming to clarify whether OS plays a causal role in CD development.
  • Researchers identified differentially expressed OS-related genes in CD, prioritized potential causal genes such as BAD, SHC1, STAT3, and MUC1, and explored how genetic regulation and gut microbiota may influence OS gene expression and disease risk.
  • The findings were validated across multiple datasets, revealing complex interactions between host genetics, epigenetic modifications, and microbiota, which could offer new insights into the mechanisms driving Crohn's disease and potential targets for intervention.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Shixian
@Shixian00000 · X

Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co/ABGnmFizIV https://t.co/Fij3KkY53X

May 11, 2023 · 12 likes · 9 shares · 100 followers View post →
Hannah Went
@EverythingEpi · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study #everythingepigenetics https://t.co/SuJdSi9ySe

May 12, 2023 · 4 likes · 1 share · 553 followers View post →
MR_lit
@Mendelian_lit · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study https://t.co/Su6INB9I0G

May 12, 2023 · 2 likes · 1 share · 1,838 followers View post →
BMC Medicine
@BMCMedicine · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 15, 2023 · 9 shares · 9,189 followers View post →
Microbiome Articles
@microbe_article · X

Oxidative stress gene expression, dna methylation, and gut microbiota interaction trigger crohn's disease: a multi-omics mendel... - Xu S et al. - https://t.co/YsIdTUktLI #microbiome

May 12, 2023 · 7,156 followers View post →
iMeta
@iMetaScience · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 12, 2023 · 9 shares · 2,877 followers View post →

All mentions

Ildiko ☕️
@IldikoMe · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

Jun 3, 2023 · 9 shares · 1,741 followers View post →
BMC Medicine
@BMCMedicine · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 15, 2023 · 9 shares · 9,189 followers View post →
GutMicrobiomePapers
@GutPapers · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study https://t.co/jEWqLinOn3

May 13, 2023 · 519 followers View post →
Yu-Feng Huang 黄钰沣
@huangyu02736240 · X

RT @eQTL_papers: Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics M…

May 13, 2023 · 1 share · 110 followers View post →
Zhaoli
@zhaoli666li · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 13, 2023 · 9 shares · 25 followers View post →
TruDiagnostic
@TruDiagnostic · X

RT @EverythingEpi: Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics…

May 12, 2023 · 1 share · 1,338 followers View post →
Transcriptomes
@transcriptomes · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Cro... https://t.co/3cw3eM847r

May 12, 2023 · 1,809 followers View post →
Arno Bourgonje
@BourgonjeArno · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 12, 2023 · 9 shares · 296 followers View post →
Hannah Went
@EverythingEpi · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study #everythingepigenetics https://t.co/SuJdSi9ySe

May 12, 2023 · 4 likes · 1 share · 553 followers View post →
T Tian
@gdsttian · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 12, 2023 · 9 shares · 136 followers View post →
iMeta
@iMetaScience · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 12, 2023 · 9 shares · 2,877 followers View post →
Microbiome Articles
@microbe_article · X

Oxidative stress gene expression, dna methylation, and gut microbiota interaction trigger crohn's disease: a multi-omics mendel... - Xu S et al. - https://t.co/YsIdTUktLI #microbiome

May 12, 2023 · 7,156 followers View post →
J Sam
@JaicSam · X

RT @Mendelian_lit: Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics…

May 12, 2023 · 1 share · 984 followers View post →
DNAMethylationPapers
@DNAmPapers · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study https://t.co/tlqNPz0c7h https://t.co/eowpNTpam8

May 12, 2023 · 703 followers View post →
Shiqiang
@ShiqiangS · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 12, 2023 · 9 shares · 32 followers View post →
Fix News Peak
@fix_newspeak · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study https://t.co/yLyYHxjvzr #TrendingNow #HotTopics #Trending #News #NewsUpdate #MyForumLink #BreakingNews

May 12, 2023 · 794 followers View post →
MR_lit
@Mendelian_lit · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study https://t.co/Su6INB9I0G

May 12, 2023 · 2 likes · 1 share · 1,838 followers View post →
eQTLpapers
@eQTL_papers · X

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study https://t.co/HxyrI6Yu8M https://t.co/wk3nT9x3Rw

May 12, 2023 · 1 share · 626 followers View post →
Arnau Vich Vila
@arnauvich · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 11, 2023 · 9 shares · 591 followers View post →
Cancan
@CancanQi · X

RT @Shixian00000: Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co…

May 11, 2023 · 9 shares · 59 followers View post →
Shixian
@Shixian00000 · X

Please check our recent paper: we provide statistical evidence of causality between oxidative stress and CD. https://t.co/ABGnmFizIV https://t.co/Fij3KkY53X

May 11, 2023 · 12 likes · 9 shares · 100 followers View post →