Nat Commun April 2023 PMID 37185345

Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning.

Can Chen, Chen Liao, Yang-Yu Liu

Mentions

17
Peak: 5 in Jun 2022
across 3 sources since Jun 2022

Extended reach

211,337
potential audience

Total likes

10

Video views

9

Mentions per month

Jun 2022 – Jul 2023

Where it's discussed

  • X / Twitter14 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone indicates positive recognition of the research's novelty, with mentions of the deep learning approach and its ability to improve genome-scale metabolic models, using phrases like 'teasing out missing reactions' and 'outperforms existing methods.' The frequent references to conferences, publications, and the technical language reflect both high interest and engagement, emphasizing the study's potential impact in computational biology.

AgreementModerate agreement

Most discussions highlight the significance and innovation of the research, with some expressions of support and recognition of its potential.

InterestHigh interest

Posts consistently show high curiosity about the methodology and implications, indicating strong academic and professional interest.

EngagementModerate engagement

Comments reference specific methods like hypergraph learning and emphasize the importance of filling knowledge gaps, demonstrating moderate depth of engagement.

ImpactModerate impact

The discussions suggest the publication could influence future research and tool development within metabolic modeling, though evidence of widespread adoption isn't explicit.

Abstract in brief

  • The study introduces a new deep learning tool called CHESHIRE that predicts missing reactions in genome-scale metabolic models (GEMs) using only the network's structure, without needing experimental data.
  • CHESHIRE outperforms existing methods by accurately identifying omitted reactions across over 900 high-quality GEMs and enhances predictions of metabolic outputs like fermentation products and amino acids.
  • This approach helps quickly and reliably fill knowledge gaps in metabolic networks, aiding the understanding and curation of GEMs to better reflect real cellular processes.

Top posts

Most liked on X and Bluesky
Marinka Zitnik
@marinkazitnik · X

Final talk in the morning session #biodata22 by Can Chen on teasing out missing reactions in genome‐scale metabolic networks through deep learning @BrighamWomens https://t.co/igmT4IMGTc

Nov 11, 2022 · 4 likes · 1 share · 8,214 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning https://t.co/9V9UwaI7md #biorxiv_bioinfo

Jun 29, 2022 · 2 likes · 18,069 followers View post →
bioRxiv
@biorxivpreprint · X

Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning https://t.co/Til67hNHvF #bioRxiv

Jun 29, 2022 · 1 like · 136,941 followers View post →
Michael Schatz
@mike_schatz · X

Closing out the ML session is Can Chen on “Teasing out missing reactions in genome‐scale metabolic networks through deep learning” #biodata22 https://t.co/z0C3yd23i9

Nov 11, 2022 · 1 like · 16,157 followers View post →
SeqComplete
@SeqComplete · X

#BioIT #BioInformatics Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning [NEW RESULTS] https://t.co/ngQZ2vVRtJ

Jun 30, 2022 · 1 like · 1 share · 4,413 followers View post →
Paul Lopez
@lopezunwired · X

Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning https://t.co/RTz6XA1wIf #MachineLearning #NatureJournal #AI https://t.co/3QK5k2maUL

Apr 25, 2023 · 1 like · 2,480 followers View post →

All mentions

MSK Library
@MSKLibrary · X

Featured today by @MSKLibrary: Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning https://t.co/xvaTy2xMKT @cliao345

May 24, 2023 · 2,964 followers View post →
Deep_In_Depth
@Deep_In_Depth · X

Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning https://t.co/3jS3GrxYuC #DL #AI #ML #DeepLearning #ArtificialIntelligence #MachineLearning #ComputerVision #AutonomousVehicles #NeuroMorphic #Robotics

Apr 26, 2023 · 14,554 followers View post →
Paul Lopez
@lopezunwired · X

Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning https://t.co/RTz6XA1wIf #MachineLearning #NatureJournal #AI https://t.co/3QK5k2maUL

Apr 25, 2023 · 1 like · 2,480 followers View post →
LUKMAN AFOLABI
@saintlukman · X

Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning https://t.co/rPJrYRS05q https://t.co/RhL79Is4hB

Apr 25, 2023 · 922 followers View post →
Reluctant Quant
@DrMattCrowson · X

RT Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning https://t.co/Scz41IqFuL https://t.co/sRNQ2OlGAS

Apr 25, 2023 · 1,260 followers View post →
MΛRCOS COLEBROOK
@MColebrook · X

RT @marinkazitnik: Final talk in the morning session #biodata22 by Can Chen on teasing out missing reactions in genome‐scale metabolic netw…

Nov 11, 2022 · 1 share · 1,427 followers View post →
Matt Holt
@holtjma · X

Can Chen #biodata22 with "Teasing out missing reactions in genome‐scale metabolic networks through deep learning". Problem: Completeness of genome-scale metabolic models (GEMs) is challenging, existing tools for finding inconsistencies are limited in accuracy and (1/2)

Nov 11, 2022 · 549 followers View post →
Marinka Zitnik
@marinkazitnik · X

Final talk in the morning session #biodata22 by Can Chen on teasing out missing reactions in genome‐scale metabolic networks through deep learning @BrighamWomens https://t.co/igmT4IMGTc

Nov 11, 2022 · 4 likes · 1 share · 8,214 followers View post →
Michael Schatz
@mike_schatz · X

Closing out the ML session is Can Chen on “Teasing out missing reactions in genome‐scale metabolic networks through deep learning” #biodata22 https://t.co/z0C3yd23i9

Nov 11, 2022 · 1 like · 16,157 followers View post →
CompChemBio Bot
@CompChemBioBot · X

RT @SeqComplete: #BioIT #BioInformatics Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning [NEW RESULTS…

Jun 30, 2022 · 1 share · 2,761 followers View post →
SeqComplete
@SeqComplete · X

#BioIT #BioInformatics Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning [NEW RESULTS] https://t.co/ngQZ2vVRtJ

Jun 30, 2022 · 1 like · 1 share · 4,413 followers View post →
Helio Rocha
@_elioRocha · X

#bioRxiv Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning #bioinfo https://t.co/SUxMlDas6H

Jun 30, 2022 · 609 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning https://t.co/9V9UwaI7md #biorxiv_bioinfo

Jun 29, 2022 · 2 likes · 18,069 followers View post →
bioRxiv
@biorxivpreprint · X

Teasing out Missing Reactions in Genome-scale Metabolic Networks through Deep Learning https://t.co/Til67hNHvF #bioRxiv

Jun 29, 2022 · 1 like · 136,941 followers View post →