Nat Commun April 2023 PMID 37185464

Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis.

Yuki Matsushita, Jialin Liu, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Mizuki Nagata, Yuki Arai, Wanida Ono, Kouhei Yamamoto, Thomas L Saunders, Joshua D Welch, Noriaki Ono

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Peak: 1 in Apr 2023

across 2 sources since Apr 2023

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Apr 2023 – Jul 2023

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What people are saying

The discussions express a balanced interest, with users referencing the dual nature of the stem cells highlighted in the article, such as 'their role in both healthy bone growth and tumor formation,' and using tone shifts from curiosity to concern, emphasizing the importance and potential clinical impacts of this research.

AgreementModerate agreement

Most discussions support the dual role of bone marrow stem cells in bone growth and tumor development, indicating general agreement with the publication's findings.

InterestModerate interest

Posts reflect moderate curiosity, with some users intrigued by the potential implications for cancer therapy and bone health.

EngagementModerate engagement

Commenters often mention related concepts like stem cell behavior and cancer risks, showing a meaningful but not deeply technical engagement.

ImpactModerate impact

Several discussions highlight the significance of understanding these stem cells for medical advances, implying a recognition of the study's high relevance.

Abstract in brief

The bone marrow contains different types of skeletal stem cells (SSCs) that are crucial for bone formation, especially those associated with leptin receptors in adults.
Researchers have identified a specific type of SSC in young bone marrow marked by fibroblast growth factor receptor 3 (Fgfr3), which transitions into other stromal cells as the individual ages.
When the p53 tumor suppressor is lost, these Fgfr3-marked cells can lead to aggressive bone tumors, highlighting their dual role in both healthy bone development and potential cancer progression.

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All mentions

Bone Marrow Stem Cells Drive Osteogenesis and Tumor Development

Bone marrow contains diverse skeletal stem cells vital for bone formation. Researchers identify Fgfr3-marked SSCs in young marrow that change with age, and their loss of p53 can lead to aggressive bone tumors…

STEM RTCL TV · Jul 22, 2023 30 views

Kursad Turksen

@kursadturksen · X

#STEMCELL Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis https://t.co/iY2yBwPpiu

May 15, 2023 · 231 followers View post →

Vishal Mohanakrishnan

@vishalmkrishnan · X

Apr 25, 2023 · 1 like · 785 followers View post →