Microb Biotechnol July 2023 PMID 37191200

Modes-of-action of antifungal compounds: Stressors and (target-site-specific) toxins, toxicants, or toxin-stressors.

Delphine Noel, John E Hallsworth, Eric Gelhaye, Sylvain Darnet, Rodnay Sormani, Mélanie Morel-Rouhier

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Mentions

Peak: 22 in May 2023

across 3 sources since May 2023

Extended reach

54,849

potential audience

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Mentions per month

May 2023 – Mar 2025

Where it's discussed

X / Twitter25 posts
Bluesky1 posts
YouTube1 videos

AI synopsis

What people are saying

The overall tone suggests a collective recognition of the significance of understanding antifungal mechanisms, as seen in phrases like 'champions the use of safe and sustainable antifungals' and 'show modes-of-action,' which indicate both appreciation and active interest. The use of words like 'fascinating' and references to sustainable development goals demonstrate enthusiasm and acknowledgment of the research's broader implications, contributing to a consensus of positive engagement.

AgreementModerate agreement

Most discussions reflect agreement with the importance and relevance of the research, emphasizing sustainable and safe antifungal strategies.

InterestModerate interest

Participants show moderate interest, often engaging with specific aspects like classifications and applications, but not delving deeply into technical details.

EngagementModerate engagement

Comments display active engagement through sharing multiple sources, expressing approval, and discussing ecological and health implications.

ImpactModerate impact

The discussions highlight the potential influence of the research on broader applications in health, agriculture, and sustainability, indicating a moderate to high impact.

Abstract in brief

This text explains different ways antifungal compounds work, including whether they cause cellular stress, act as toxins, target specific sites in fungal cells, or have a hybrid mode called toxinstressors which induce stress while targeting specific sites, such as cell membranes activated by light.
It highlights the challenge of identifying these modes of action, especially in fungi where molecular tools are limited, and suggests using various scientific approaches like metabolite analysis, chemical genetics, and transcriptomics to better understand how antifungal substances work.
The article emphasizes the importance of classifying stressors, toxic substances, and toxinstressors for all cellular life, discusses decision trees to differentiate these modes, and considers ecological scenarios where multiple substances together affect fungal cells.]

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All mentions

Understanding Modes of Action of Antifungal Compounds in Fungi

This video explains how antifungal compounds work, including cellular stress, toxins, and target-specific actions like toxinstressors, highlighting scientific approaches to better understand these mechanisms and their…

STEM RTCL TV · Sep 18, 2023 2 views

Mélanie Morel-Rouhier

@melmorel-rouhier.bsky.social · Bluesky

Our #TopCitedArticle

Mar 19, 2025 · 4 likes · 3 shares View post →

Kenneth Timmis

@KennethTimmis · X

RT @vdlorenzo_CNB: Frequent confusion: compounds that cause cellular stress & those that cause toxicity are different—not only in fungi. Ye…

Jun 6, 2023 · 1 share · 1,234 followers View post →

Víctor de Lorenzo

@vdlorenzo_CNB · X

Frequent confusion: compounds that cause cellular stress & those that cause toxicity are different—not only in fungi. Yet some compounds called *toxin-stressors* are hybrid

Jun 6, 2023 · 5 likes · 1 share · 13,395 followers View post →

Kenneth Timmis

@KennethTimmis · X

Fascinating piece on anti-fungals: https://t.co/eurJi5U4ru

Jun 2, 2023 · 1,234 followers View post →