But just because it works in a petri dish doesn’t mean it will work on a living creature, so the next step is to make some mice a little mushroom saute (RIP Mickey). But hey, it worked! ICG significantly improved mice’s survival rate! MICKEY LIVES!
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity.
Mentions
Extended reach
Total likes
Video views
Mentions per month
May 2023 – Dec 2024Where it's discussed
-
News149 articles
-
X / Twitter19 posts
-
Blogs15 articles
-
Facebook3 posts
-
Reddit2 posts
-
YouTube1 videos
AI synopsis
What people are saying
The overall tone reflects enthusiasm and support, with phrases like 'could this save lives?' and 'Mickey lives!', indicating high interest and perceived importance. Some posts discuss the scientific process and potential applications, emphasizing both curiosity and recognition of the research's impact on future treatments.
Most discussions express support or optimism about the research and its potential implications, indicating general agreement with the findings.
The discussions highlight curiosity and excitement, especially regarding the possibility of an antidote for mushroom poisoning and the scientific advancements involved.
Participants delve into the scientific methods, such as CRISPR screening and animal trials, showing active interest and some depth of engagement.
The posts suggest this research could have a significant impact on medical treatment for mushroom poisoning, emphasizing its potential life-saving value.
Abstract in brief
- This study identifies STT3B as a key factor in amanitin toxicity, which is the deadly toxin in the death cap mushroom, and shows that inhibiting STT3B with indocyanine green (ICG) can serve as a specific antidote.
- Using advanced techniques like CRISPR screening, drug simulation, and animal testing, the researchers found that disrupting the glycan biosynthesis pathway involving STT3B reduces amanitin's harmful effects.
- The findings demonstrate that ICG effectively blocks amanitin's toxicity in cells, liver organoids, and mice, significantly improving survival, making it a promising potential treatment for mushroom poisoning.
Top posts
Most liked on X and Bluesky【原著論文】 Wang, B, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun 14, 2241 (2023). 【参考文献】 Deadly mushroom poison might now have an antidote — with help from CRISPR https://t.co/AABzvWENVd
Un antidote pour l’intox aux amanites phalloïdes ! #medtweeter @Gilou180 @univbordeaux @clouzeau_b Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/ys17y6uQB3
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity https://t.co/y2C4HKtiSM
【テングタケの解毒剤】インドシアニングリーンにタマゴテングタケの毒性軽減効果が発見され、待望の解毒剤開発へ!推理小説のトリックにも使われそうですね
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications ファロイジンの毒キノコ https://t.co/5RpZTdlRQf
All mentions
Indocyanine Green as a Potential Treatment for Mushroom Amanitin Toxicity
This study identifies STT3B as a key factor in amanitin toxicity from the death cap mushroom and demonstrates that inhibiting STT3B with indocyanine green can serve as a potential antidote. The research shows ICG…
Scientists identify STT3B as key to α-amanitin toxicity from the deadly Amanita phalloides. Indocyanine green (ICG) emerges as a potential antidote. Could this save lives? PMID:37193694, Nat Commun 2023, @NatureComms https://t.co/87tinzrx1e
RT @annethegnome: But just because it works in a petri dish doesn’t mean it will work on a living creature, so the next step is to make som…
But just because it works in a petri dish doesn’t mean it will work on a living creature, so the next step is to make some mice a little mushroom saute (RIP Mickey). But hey, it worked! ICG significantly improved mice’s survival rate! MICKEY LIVES!
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/H8GfgdL07V
"Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity" Wang B, Wan AH, Xu Y [..] Wan G, Wang QP. Nat Commun. 2023-05-16. https://t.co/bXQQ3vers0 #CRISPR-Cas9 KO screen; in silico drug screening; in vivo functional validation
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity // Adnabod indocyanine gwyrdd fel atalydd STT3B yn erbyn 'cytotoxicity' madarch α-amanitin https://t.co/erclII0lDE
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity https://t.co/gLwHF4Td1V
【テングタケの解毒剤】インドシアニングリーンにタマゴテングタケの毒性軽減効果が発見され、待望の解毒剤開発へ!推理小説のトリックにも使われそうですね
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/RboZaDc8aF
同じテングタケの中でもタマゴテングタケは猛毒で、きのこによる中毒死の原因で相当数を占めるそう、つまり解毒剤が無い。この突破口になるかもしれない論文が発表された。https://t.co/q7qz8iMZ9C
RT @EtienneRivire1: Un antidote pour l’intox aux amanites phalloïdes ! #medtweeter @Gilou180 @univbordeaux @clouzeau_b Identificatio…
RT @takatoh_life: 【原著論文】 Wang, B, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity.…
【原著論文】 Wang, B, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun 14, 2241 (2023). 【参考文献】 Deadly mushroom poison might now have an antidote — with help from CRISPR https://t.co/AABzvWENVd
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. The authors hypothesized that the blockage of N-glycans of amatoxin transporters may hinder its recognition, which contributes to the resistance https://t.co/AUJ7xETYJz https://t.co/jty1s0olO0
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications ファロイジンの毒キノコ https://t.co/5RpZTdlRQf
The paper in "Nature Communications" the above "Nature" piece is based upon, & links to: “Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity” 2/2 https://t.co/kuk3XHkIC1
Un antidote pour l’intox aux amanites phalloïdes ! #medtweeter @Gilou180 @univbordeaux @clouzeau_b Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/ys17y6uQB3
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity https://t.co/y2C4HKtiSM
Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/LBoc9QzbPy