Nat Commun May 2023 PMID 37193694

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity.

Bei Wang, Arabella H Wan, Yu Xu, Ruo-Xin Zhang, Ben-Chi Zhao, Xin-Yuan Zhao, Yan-Chuan Shi, Xiaolei Zhang, Yongbo Xue, Yong Luo, Yinyue Deng, G Gregory Neely, Guohui Wan, Qiao-Ping Wang

Mentions

189
Peak: 16 in May 2023
across 6 sources since May 2023

Extended reach

59,301
potential audience

Total likes

212

Video views

86

Mentions per month

May 2023 – Dec 2024

Where it's discussed

  • News149 articles
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  • Blogs15 articles
  • Facebook3 posts
  • Reddit2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects enthusiasm and support, with phrases like 'could this save lives?' and 'Mickey lives!', indicating high interest and perceived importance. Some posts discuss the scientific process and potential applications, emphasizing both curiosity and recognition of the research's impact on future treatments.

AgreementModerate agreement

Most discussions express support or optimism about the research and its potential implications, indicating general agreement with the findings.

InterestHigh interest

The discussions highlight curiosity and excitement, especially regarding the possibility of an antidote for mushroom poisoning and the scientific advancements involved.

EngagementModerate engagement

Participants delve into the scientific methods, such as CRISPR screening and animal trials, showing active interest and some depth of engagement.

ImpactHigh impact

The posts suggest this research could have a significant impact on medical treatment for mushroom poisoning, emphasizing its potential life-saving value.

Abstract in brief

  • This study identifies STT3B as a key factor in amanitin toxicity, which is the deadly toxin in the death cap mushroom, and shows that inhibiting STT3B with indocyanine green (ICG) can serve as a specific antidote.
  • Using advanced techniques like CRISPR screening, drug simulation, and animal testing, the researchers found that disrupting the glycan biosynthesis pathway involving STT3B reduces amanitin's harmful effects.
  • The findings demonstrate that ICG effectively blocks amanitin's toxicity in cells, liver organoids, and mice, significantly improving survival, making it a promising potential treatment for mushroom poisoning.

Top posts

Most liked on X and Bluesky
Gnome Anne May Perceive Me
@annethegnome · X

But just because it works in a petri dish doesn’t mean it will work on a living creature, so the next step is to make some mice a little mushroom saute (RIP Mickey). But hey, it worked! ICG significantly improved mice’s survival rate! MICKEY LIVES!

Jun 27, 2024 · 192 likes · 1 share · 26,706 followers View post →
高遠 頼@生命科学VTuber(たかとー らい) 定期科学ニュース配信(日)
@takatoh_life · X

【原著論文】 Wang, B, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun 14, 2241 (2023). 【参考文献】 Deadly mushroom poison might now have an antidote — with help from CRISPR https://t.co/AABzvWENVd

May 18, 2023 · 7 likes · 1 share · 13,654 followers View post →
Etienne Rivière
@EtienneRivire1 · X

Un antidote pour l’intox aux amanites phalloïdes ! #medtweeter ⁦@Gilou180⁩ ⁦@univbordeaux⁩ ⁦@clouzeau_b⁩ Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/ys17y6uQB3

May 17, 2023 · 6 likes · 1 share · 195 followers View post →
hexaOrthorexia
@hexaOrthorexia · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity https://t.co/y2C4HKtiSM

May 16, 2023 · 2 likes · 1 share · 1,502 followers View post →
新しい天使
@neostenshi · X

【テングタケの解毒剤】インドシアニングリーンにタマゴテングタケの毒性軽減効果が発見され、待望の解毒剤開発へ!推理小説のトリックにも使われそうですね

May 20, 2023 · 1 like · 4,099 followers View post →
a
@ayanosatoh · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications ファロイジンの毒キノコ https://t.co/5RpZTdlRQf

May 17, 2023 · 1 like · 623 followers View post →

All mentions

Shicheng Guo
@ShihchengGuo · X

Scientists identify STT3B as key to α-amanitin toxicity from the deadly Amanita phalloides. Indocyanine green (ICG) emerges as a potential antidote. Could this save lives? PMID:37193694, Nat Commun 2023, @NatureComms https://t.co/87tinzrx1e

Dec 20, 2024 · 501 followers View post →
Rafaellcord
@Rafaellcord · X

RT @annethegnome: But just because it works in a petri dish doesn’t mean it will work on a living creature, so the next step is to make som…

Jun 27, 2024 · 1 share · 613 followers View post →
Gnome Anne May Perceive Me
@annethegnome · X

But just because it works in a petri dish doesn’t mean it will work on a living creature, so the next step is to make some mice a little mushroom saute (RIP Mickey). But hey, it worked! ICG significantly improved mice’s survival rate! MICKEY LIVES!

Jun 27, 2024 · 192 likes · 1 share · 26,706 followers View post →
MaNoV BioteClinica
@BioteClinica · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/H8GfgdL07V

May 25, 2023 · 24 followers View post →
CRISP_SCIENCE
@ScienceCrisp · X

"Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity" Wang B, Wan AH, Xu Y [..] Wan G, Wang QP. Nat Commun. 2023-05-16. https://t.co/bXQQ3vers0 #CRISPR-Cas9 KO screen; in silico drug screening; in vivo functional validation

May 24, 2023 · 1,917 followers View post →
WalesTox - TocsCymru
@WalesTox · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity // Adnabod indocyanine gwyrdd fel atalydd STT3B yn erbyn 'cytotoxicity' madarch α-amanitin https://t.co/erclII0lDE

May 23, 2023 · 226 followers View post →
SG
@719AbcXyz · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity https://t.co/gLwHF4Td1V

May 21, 2023 · 111 followers View post →
新しい天使
@neostenshi · X

【テングタケの解毒剤】インドシアニングリーンにタマゴテングタケの毒性軽減効果が発見され、待望の解毒剤開発へ!推理小説のトリックにも使われそうですね

May 20, 2023 · 1 like · 4,099 followers View post →
ぜのぱす(初代_凍結から快復)
@Xenopus007 · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/RboZaDc8aF

May 18, 2023 · 855 followers View post →
あつこ@彷徨える大衆 (Atsuko)
@plutoatsuko · X

同じテングタケの中でもタマゴテングタケは猛毒で、きのこによる中毒死の原因で相当数を占めるそう、つまり解毒剤が無い。この突破口になるかもしれない論文が発表された。https://t.co/q7qz8iMZ9C

May 18, 2023 · 107 followers View post →
Thomas Moulinet
@MoulinetThomas · X

RT @EtienneRivire1: Un antidote pour l’intox aux amanites phalloïdes ! #medtweeter ⁦@Gilou180⁩ ⁦@univbordeaux⁩ ⁦@clouzeau_b⁩ Identificatio…

May 18, 2023 · 1 share · 71 followers View post →
原 拓史
@haltaq · X

RT @takatoh_life: 【原著論文】 Wang, B, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity.…

May 18, 2023 · 1 share · 3,484 followers View post →
高遠 頼@生命科学VTuber(たかとー らい) 定期科学ニュース配信(日)
@takatoh_life · X

【原著論文】 Wang, B, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun 14, 2241 (2023). 【参考文献】 Deadly mushroom poison might now have an antidote — with help from CRISPR https://t.co/AABzvWENVd

May 18, 2023 · 7 likes · 1 share · 13,654 followers View post →
Khoo KH
@khooAS · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. The authors hypothesized that the blockage of N-glycans of amatoxin transporters may hinder its recognition, which contributes to the resistance https://t.co/AUJ7xETYJz https://t.co/jty1s0olO0

May 17, 2023 · 1 like · 90 followers View post →
a
@ayanosatoh · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications ファロイジンの毒キノコ https://t.co/5RpZTdlRQf

May 17, 2023 · 1 like · 623 followers View post →
Andy_Weeble_Weaver
@AndrewW66619812 · X

The paper in "Nature Communications" the above "Nature" piece is based upon, & links to: “Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity” 2/2 https://t.co/kuk3XHkIC1

May 17, 2023 · 4,319 followers View post →
Etienne Rivière
@EtienneRivire1 · X

Un antidote pour l’intox aux amanites phalloïdes ! #medtweeter ⁦@Gilou180⁩ ⁦@univbordeaux⁩ ⁦@clouzeau_b⁩ Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/ys17y6uQB3

May 17, 2023 · 6 likes · 1 share · 195 followers View post →
hexaOrthorexia
@hexaOrthorexia · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity https://t.co/y2C4HKtiSM

May 16, 2023 · 2 likes · 1 share · 1,502 followers View post →
NewcastleCPT
@CptNewcastle · X

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity | Nature Communications https://t.co/LBoc9QzbPy

May 16, 2023 · 1 like · 105 followers View post →