Nat Commun May 2023 PMID 37208326

Antibody binding reports spatial heterogeneities in cell membrane organization.

Daniel P Arnold, Yaxin Xu, Sho C Takatori

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Peak: 8 in Nov 2022

across 2 sources since Nov 2022

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Nov 2022 – Aug 2023

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AI synopsis

What people are saying

The overall tone reflects an appreciation for the detailed insights into cell membrane organization, with comments mentioning how the study 'supports the idea' of membrane heterogeneity and discussing potential improvements in antibody design. Words like 'valuable', 'significant', and 'implications' highlight the perceived importance of the research while showing a moderate level of engagement and interest through references to specific scientific concepts and potential applications.

AgreementModerate agreement

Most discussions recognize the significance of the research, with many referencing it as a valuable contribution to understanding membrane heterogeneity.

InterestModerate interest

Posts indicate a moderate level of curiosity, especially among those mentioning applications like antibody design and membrane organization.

EngagementModerate engagement

The discussions show some depth, with posts referencing specific aspects such as binding affinity variability and membrane regions like raft domains.

ImpactModerate impact

Several comments suggest that the findings could influence future research and practical applications, hinting at a notable scientific impact.

Abstract in brief

This study combines experiments and simulations to analyze the organization of cell membrane components at a very small, nanometer scale, revealing that different regions of the membrane have varying levels of crowding that can influence how molecules like antibodies bind.
It shows that antibodies, specifically IgG monoclonal antibodies, experience sharp differences in binding affinity near the membrane surface, indicating the presence of dense or crowded regions.
The research supports the idea that certain membrane areas, like raft-like domains, exclude larger proteins, which impacts membrane behavior and could help improve antibody design and understanding of cell membrane structure.

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Mapping Cell Membrane Organization with Antibody Binding Analysis

This study combines experiments and simulations to analyze the organization of cell membrane components at a nanometer scale, revealing regions with varying crowding that influence antibody binding. It enhances…

STEM RTCL TV · Aug 19, 2023 15 views

Nature Communications

@NatureComms · X

Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/GeCiwSV4UU

Jun 7, 2023 · 3 likes · 248,512 followers View post →

Dieter

@Wuhle · X

RT @NatureComms: Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/GeCiwSV4UU

Jun 5, 2023 · 1 share · 477 followers View post →

Nature Communications

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Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/GeCiwSV4UU

Jun 5, 2023 · 4 likes · 1 share · 248,512 followers View post →

Nick Ariotti

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RT @lipidchronicles: Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/AkAMQrvg2H (@NatureComms)

May 26, 2023 · 3 shares · 144 followers View post →

Toyota_Group_Komaba

@KomaToug · X

RT @lipidchronicles: Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/AkAMQrvg2H (@NatureComms)

May 24, 2023 · 3 shares · 668 followers View post →

Kasparas Petkevicius

@Kasparas_lab · X

RT @lipidchronicles: Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/AkAMQrvg2H (@NatureComms)

May 24, 2023 · 3 shares · 233 followers View post →

The Lipid Chronicles

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Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/AkAMQrvg2H (@NatureComms)

May 23, 2023 · 8 likes · 3 shares · 5,854 followers View post →

Kato

@oxkawaka · X

Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/zNIaczuBFK

May 20, 2023 · 2 likes · 5,815 followers View post →

arXiv physics.bio-ph

@ArxivBiophys · X

Antibody binding reports spatial heterogeneities in cell membrane organization. (arXiv:2211.12022v2 [physics.bio-ph] UPDATED) https://t.co/b3fHZdaGSv

Dec 6, 2022 · 59 followers View post →

arXiv cond-mat.soft

@ArxivSoftMat · X

Antibody binding reports spatial heterogeneities in cell membrane organization. (arXiv:2211.12022v2 [physics.bio-ph] UPDATED) https://t.co/GIebyEZWuC

Dec 6, 2022 · 66 followers View post →

biophotonicat

@biophotonicat · X

Antibody binding reports spatial heterogeneities in cell membrane organization (relevance: 49%) https://t.co/OmHuqVF7Zb #biophotonics #biomedicaloptics https://t.co/VAboPIXHy6

Nov 23, 2022 · 1,529 followers View post →

Unreadable Preprint Bot

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Antibody binding reports spatial heterogeneities in cell membrane organization FK grade 20 (very unreadable)

Nov 23, 2022 · 16 followers View post →

soft/living matter fanclub

@softlivmat_fc · X

D. P. Arnold, Y. Xu, S. C. Takatori, Antibody binding reports spatial heterogeneities in cell membrane organization. arXiv [physics.bio-ph] (2022). https://t.co/wxViZ3Cpcd

Nov 23, 2022 · 2 likes · 1,527 followers View post →

arXiv cond-mat.soft

@ArxivSoftMat · X

Antibody binding reports spatial heterogeneities in cell membrane organization. (arXiv:2211.12022v1 [physics.bio-ph]) https://t.co/6JkmDLg6xM

Nov 22, 2022 · 66 followers View post →

bioRxiv Biophysics

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Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/l3ZTwGEvhM #biorxiv_biophys

Nov 22, 2022 · 5,378 followers View post →

bioRxiv

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Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/y57TAd4hRs #bioRxiv

Nov 22, 2022 · 136,946 followers View post →

arXiv physics.bio-ph

@ArxivBiophys · X

Antibody binding reports spatial heterogeneities in cell membrane organization. (arXiv:2211.12022v1 [physics.bio-ph]) https://t.co/OBOrcSz4Ol

Nov 22, 2022 · 59 followers View post →

arXiv physics

@_arXiv_physics · X

[2211.12022] Daniel P. Arnold, Yaxin Xu, Sho C. Takatori: Antibody binding reports spatial heterogeneities in cell membrane organization https://t.co/wK5s3GC72y https://t.co/8kVOcoOVen #physics_bio_ph

Nov 22, 2022 · 1,150 followers View post →

Antibody binding reports spatial heterogeneities in cell membrane organization.

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Mapping Cell Membrane Organization with Antibody Binding Analysis