Global, regional, and national time trends in incidence, prevalence, years lived with disability for uterine fibroids, 1990-2019: an age-period-cohort analysis for the global burden of disease 2019 study.

Abstract in brief

• Uterine fibroids are the most common benign tumors of the uterus and have increasingly contributed to women’s health issues globally from 1990 to 2019, with rises in incidence, prevalence, and years lived with disability (YLDs).
• The study analyzed data from 204 countries using an age–period–cohort model, revealing that higher socioeconomic status countries generally experienced decreasing trends, while middle and low-income regions saw increases in fibroid cases and related disability rates over the past 30 years.
• Age impacts fibroid rates significantly, peaking in women aged 35–44, and both period and cohort effects also influence prevalence and disability, highlighting complex interactions between age, societal factors, and generational changes in fibroid burden.