PLoS Med May 2023 PMID 37216371

Global, regional, and national estimates of the impact of a maternal Klebsiella pneumoniae vaccine: A Bayesian modeling analysis.

Chirag K Kumar, Kirsty Sands, Timothy R Walsh, Seamus O'Brien, Mike Sharland, Joseph A Lewnard, Hao Hu, Padmini Srikantiah, Ramanan Laxminarayan

Mentions

12
Peak: 7 in May 2023
across 3 sources since May 2023

Extended reach

20,202
potential audience

Total likes

18

Video views

15

Mentions per month

May 2023 – Sep 2023

Where it's discussed

  • X / Twitter7 posts
  • News4 articles
  • YouTube1 videos

AI synopsis

What people are saying

The posts reflect strong support and intrigue around the research's implications, exemplified by phrases like 'a maternal vaccine could avert over 80,000 deaths' and references to the persistent challenge of bacterial sepsis. The tone is informative yet optimistic, underscoring the potential public health impact of the findings and demonstrating engaged discourse on innovative solutions to neonatal mortality.

AgreementModerate agreement

Most discussions acknowledge the importance of addressing neonatal sepsis and support the potential benefits of maternal vaccination highlighted in the publication.

InterestHigh interest

Posts show a high level of interest, especially with references to specific findings like the potential to prevent over 80,000 neonatal deaths, indicating they find the topic compelling and relevant.

EngagementModerate engagement

The discussions include mentions of the research methodology and its significance, such as Bayesian modeling, demonstrating moderate depth of engagement and analytical thinking.

ImpactHigh impact

Participants perceive the study as highly impactful, emphasizing its potential to save lives and influence public health strategies, with language such as 'could avert' and 'major cause of neonatal deaths.'

Abstract in brief

  • Neonatal mortality rates have decreased globally, but bacterial sepsis, particularly from Klebsiella pneumoniae, continues to be a leading cause of death among newborns, often resistant to standard antibiotic treatments.
  • The study models the potential impact of a hypothetical maternal K. pneumoniae vaccine, estimated at 70% efficacy, to reduce neonatal infections and fatalities in low- and middle-income countries by analyzing data from comprehensive neonatal studies across various regions.
  • Researchers assessed the accumulation of antibiotic resistance in K. pneumoniae to forecast an increase in resistant cases, emphasizing the importance of maternal vaccination as a strategic public health intervention.

Top posts

Most liked on X and Bluesky
One Health Trust
@OneHealthTrust · X

A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's Ramanan Laxminarayan, found a #maternalvaccine for Klebsiella pneumoniae infections could avert 80,258 neonatal deaths. More here: https://t.co/CH96V7Jr6b

May 23, 2023 · 18 likes · 7 shares · 1,576 followers View post →
CDDEP
@CDDEP · X

RT @OneHealthTrust: A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's R…

May 23, 2023 · 7 shares · 8,636 followers View post →
neo_papers
@neo_papers · X

Global, regional, and national estimates of the impact of a maternal Klebsiella pneumoniae vaccine: A Bayesian modeling analysis #neoTwitter https://t.co/VKp05qw1cv

May 22, 2023 · 5,739 followers View post →
Ivy Mutai
@MutaiIvy · X

RT @OneHealthTrust: A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's R…

May 23, 2023 · 7 shares · 2,363 followers View post →
Dr. Elden Wayne Whalen III, ShD
@wayne_effect · X

https://t.co/oSN0zHO0c9 "Despite significant global progress in reducing neonatal mortality, bacterial sepsis remains a major cause of neonatal deaths."

May 24, 2023 · 1,270 followers View post →
✌
@Iamatewo1 · X

RT @OneHealthTrust: A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's R…

May 23, 2023 · 7 shares · 401 followers View post →

All mentions

Dr. Elden Wayne Whalen III, ShD
@wayne_effect · X

https://t.co/oSN0zHO0c9 "Despite significant global progress in reducing neonatal mortality, bacterial sepsis remains a major cause of neonatal deaths."

May 24, 2023 · 1,270 followers View post →
Jean-Pierre
@JP_Gnimatin · X

RT @OneHealthTrust: A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's R…

May 23, 2023 · 7 shares · 132 followers View post →
Ivy Mutai
@MutaiIvy · X

RT @OneHealthTrust: A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's R…

May 23, 2023 · 7 shares · 2,363 followers View post →
✌
@Iamatewo1 · X

RT @OneHealthTrust: A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's R…

May 23, 2023 · 7 shares · 401 followers View post →
CDDEP
@CDDEP · X

RT @OneHealthTrust: A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's R…

May 23, 2023 · 7 shares · 8,636 followers View post →
One Health Trust
@OneHealthTrust · X

A million babies die in their 1st month of life due to #neonatalsepsis. In @PLOSMedicine researchers, including OHT's Ramanan Laxminarayan, found a #maternalvaccine for Klebsiella pneumoniae infections could avert 80,258 neonatal deaths. More here: https://t.co/CH96V7Jr6b

May 23, 2023 · 18 likes · 7 shares · 1,576 followers View post →
neo_papers
@neo_papers · X

Global, regional, and national estimates of the impact of a maternal Klebsiella pneumoniae vaccine: A Bayesian modeling analysis #neoTwitter https://t.co/VKp05qw1cv

May 22, 2023 · 5,739 followers View post →