Nat Commun May 2023 PMID 37221157

Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation.

Kaiyuan Wang, Yang Li, Xia Wang, Zhijun Zhang, Liping Cao, Xiaoyuan Fan, Bin Wan, Fengxiang Liu, Xuanbo Zhang, Zhonggui He, Yingtang Zhou, Dong Wang, Jin Sun, Xiaoyuan Chen

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Peak: 4 in May 2023

across 3 sources since May 2023

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May 2023 – Aug 2023

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AI synopsis

What people are saying

The discussions demonstrate a high level of agreement and enthusiasm, with participants expressing excitement about the innovative gas delivery system and its activation of immune responses, describing the research as a promising advancement in tumor treatment. Words such as 'potentiates,' 'activation,' and 'potential' convey a sense of importance and optimism, indicating that the group perceives this work as impactful and highly relevant.

AgreementStrong agreement

All comments affirm the significance and effectiveness of the gas therapy approach described in the publication, indicating strong consensus.

InterestHigh interest

The discussions show high enthusiasm and curiosity about the novel method, as evidenced by the repeated mention of its potential and mechanisms.

EngagementHigh engagement

Posters delve into technical details like the cGAS-STING pathway, nanoadjuvants, and mitochondrial damage, reflecting deep engagement.

ImpactHigh impact

The tone suggests that users believe this research could be a breakthrough in cancer therapy, highlighting its transformative potential.

Abstract in brief

The study explores a new gas therapy approach that enhances photoimmunotherapy for resistant, poorly immunogenic tumors like triple-negative breast cancer by activating the cGAS-STING immune pathway.
Researchers developed a specialized nanoadjuvant that delivers gases such as hydrogen sulfide, carbon monoxide, and manganese, which are released within tumors to boost immune response and improve therapy effectiveness.
Under near-infrared laser treatment, this nanoadjuvant triggers the release of these gases, leading to mitochondrial damage and DNA leakage, which in turn activates immune responses to better target and destroy tumors.

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Enhancing Photoimmunotherapy with Gas-Activated Nanoadjuvants in Cancer Treatment

This study explores a new gas therapy approach that enhances photoimmunotherapy for resistant, poorly immunogenic tumors like triple-negative breast cancer by activating the cGAS-STING immune pathway. Researchers…

STEM RTCL TV · Aug 21, 2023 12 views

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