Nat Commun May 2023 PMID 37236967

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.

Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J F Crupi, Huy-Dung Hoang

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Mentions

13
Peak: 6 in May 2023
across 3 sources since May 2023

Extended reach

33,266
potential audience

Total likes

40

Video views

185

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter9 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The analysis reveals a generally positive and engaged response, with references to the publication as a noteworthy contribution to synthetic virology and mentions of ongoing impact, reflecting both support and the perceived importance of this research for improving oncolytic treatments.

AgreementModerate agreement

Most discussions endorse the publication, highlighting its significance in advancing oncolytic virus therapy safety and efficacy.

InterestHigh interest

Users are highly interested, as shown by enthusiastic comments and recognition of the work's importance.

EngagementModerate engagement

Posts reflect thoughtful engagement, with some sharing specific details and expressing support for the research.

ImpactModerate impact

The discussions suggest the publication's potential to influence future research and clinical applications in cancer therapy.

Abstract in brief

  • This study focuses on improving oncolytic virus therapies, specifically vaccinia virus vectors, by developing drug-controlled gene switches that allow precise regulation of viral gene expression, enhancing safety and effectiveness.
  • Researchers used ribosome profiling to design synthetic promoters that respond to FDA-approved drugs like rapamycin and doxycycline, enabling inducible gene expression with minimal background activity.
  • The developed controls help regulate various aspects of the virus, including production of fusogenic proteins and cytokines, as well as viral replication, offering a versatile toolkit for designing more precise and safe oncolytic viruses.]

Top posts

Most liked on X and Bluesky
Vega Shah
@dr_alphalyrae · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications https://t.co/vPINa5c9Re

May 28, 2023 · 17 likes · 2 shares · 18,714 followers View post →
Akio Adachi
@RQpdPyjf1VbJKTe · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies https://t.co/7Up6QQFVis

May 27, 2023 · 7 likes · 1 share · 2,665 followers View post →
Ahmad B Mahmoud, PhD
@Ahmad_B_Mahmoud · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications https://t.co/BB9V341qgP

Jul 26, 2023 · 6 likes · 1 share · 4,558 followers View post →
UChicago Chemistry
@UChiChemistry · X

Congratulations to @chembioBryan for contributing to the recent publication in @NatureComms - "Synthetic Virology Approaches to Improve the Safety and Efficacy of Oncolytic Virus Therapies" - that has already begun to find its way in the world. https://t.co/Zv0ArHJWFO

Aug 14, 2023 · 3 likes · 5,724 followers View post →
J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @dr_alphalyrae: Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications ht…

May 29, 2023 · 2 shares · 705 followers View post →
Razan Alamri
@zaza64927569 · X

RT @Ahmad_B_Mahmoud: Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications…

Jul 26, 2023 · 1 share · 250 followers View post →

All mentions

UChicago Chemistry
@UChiChemistry · X

Congratulations to @chembioBryan for contributing to the recent publication in @NatureComms - "Synthetic Virology Approaches to Improve the Safety and Efficacy of Oncolytic Virus Therapies" - that has already begun to find its way in the world. https://t.co/Zv0ArHJWFO

Aug 14, 2023 · 3 likes · 5,724 followers View post →
Razan Alamri
@zaza64927569 · X

RT @Ahmad_B_Mahmoud: Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications…

Jul 26, 2023 · 1 share · 250 followers View post →
Ahmad B Mahmoud, PhD
@Ahmad_B_Mahmoud · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications https://t.co/BB9V341qgP

Jul 26, 2023 · 6 likes · 1 share · 4,558 followers View post →
J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @dr_alphalyrae: Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications ht…

May 29, 2023 · 2 shares · 705 followers View post →
virus_genome
@virus_genome · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies https://t.co/YcL1yEgfsY https://t.co/j2VPSbqEl7

May 29, 2023 · 176 followers View post →
Vega Shah
@dr_alphalyrae · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies | Nature Communications https://t.co/vPINa5c9Re

May 28, 2023 · 17 likes · 2 shares · 18,714 followers View post →
Fredmoore Orosco, PhD
@fredmoorology · X

RT @RQpdPyjf1VbJKTe: Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies https://t.co/7Up6QQFVis

May 28, 2023 · 1 share · 246 followers View post →
Akio Adachi
@RQpdPyjf1VbJKTe · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies https://t.co/7Up6QQFVis

May 27, 2023 · 7 likes · 1 share · 2,665 followers View post →
papersformax
@papers_for_max · X

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies https://t.co/hcwYejDbHd https://t.co/927B3NxAYf

May 27, 2023 · 28 followers View post →