Nat Commun May 2023 PMID 37248241

Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo.

Katarzyna M Sitnik, Fran Krstanović, Natascha Gödecke, Ulfert Rand, Tobias Kubsch, Henrike Maaß, Yeonsu Kim, Ilija Brizić, Luka Čičin-Šain

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Mentions

Peak: 1 in May 2023

across 3 sources since May 2023

Extended reach

717

potential audience

Total likes

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Mentions per month

May 2023 – Sep 2023

Where it's discussed

News4 articles
X / Twitter1 posts
YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects genuine curiosity and support, with posts mentioning how fibroblasts serve as a critical site for viral latency and replication, emphasizing the role of Stat1 in controlling these processes. Words like 'significant', 'example', and 'impact' highlight the perceived importance and potential influence of this research on understanding viral behavior.

AgreementModerate agreement

Most discussions recognize the importance of fibroblasts in viral persistence and see the findings as relevant, with some expressing strong support.

InterestModerate interest

Participants show moderate curiosity about the mechanisms, with some discussions delving into implications for understanding viral latency.

EngagementModerate engagement

Comments indicate active engagement, referencing specific aspects like the role of Stat1 and viral reactivation, demonstrating thoughtful analysis.

ImpactModerate impact

The discussions suggest the study could influence future research directions, emphasizing its significance in virology and immunology.

Abstract in brief

Fibroblasts, specifically PDGFR-positive cells, can harbor murine cytomegalovirus (MCMV) both during active infection and latency, with viral genomes present across multiple organs.
Although viral gene activity is mostly suppressed in these fibroblasts five months after infection, they can still produce reactivated virus outside the body, indicating they support latent infection.
The protein STAT1 is crucial for maintaining viral latency in these cells; its deficiency leads to increased active viral replication but prevents the virus from establishing long-term latency.]

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All mentions

Fibroblasts as Sites of Murine Cytomegalovirus Replication and Latency

Fibroblasts, specifically PDGFR-positive cells, can harbor murine cytomegalovirus during active infection and latency. They support latent infection, with viral genomes present in multiple organs. STAT1 is crucial for…

STEM RTCL TV · Sep 25, 2023 71 views

Phage Papers

@Phage_Papers · X

Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo https://t.co/b6hMr5xdXF

May 30, 2023 · 647 followers View post →