In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not known. Researchers studied
Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR-1236/HER2 signaling pathway.
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Jun 2023 – Oct 2023Where it's discussed
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X / Twitter2 posts
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YouTube1 videos
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What people are saying
Overall, the discussions reflect a moderate level of support and curiosity, with references to both the antioxidant effects of isoliquiritigenin and the novel involvement of circRNA in glioma, evidenced by phrases like 'shows potential' and questions about the ISL-circRNA relationship. The tone combines cautious optimism with scientific curiosity, contributing to a balanced view of its potential impact.
Most discussions acknowledge the potential of isoliquiritigenin in glioma treatment, indicating general agreement with the research's significance.
Participants show moderate interest, often referencing the antioxidative and antitumor properties but expressing curiosity about the specific mechanisms.
Comments include mention of research details, such as the role of circ0030018 and the miR-1236/HER2 pathway, suggesting active engagement.
The discussions recognize the potential for this research to impact future therapeutic strategies for glioma, highlighting its relevance.
Abstract in brief
- Glioma is a common and aggressive brain tumor, and despite advancements in treatment, outcomes for high-risk patients remain inadequate.
- Isoliquiritigenin (ISL) has shown potential antitumor and antioxidative effects, leading to the discovery that it downregulates circ0030018 in glioma cells.
- Silencing circ0030018 reduces glioma cell growth and invasion, enhances oxidative stress, and functions partially through the miR-1236/HER2 signaling pathway, suggesting its potential as a therapeutic target.
Top posts
Most liked on X and BlueskyRT @cancerscnews: In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not know…
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Isoliquiritigenin Suppresses Glioma Growth via circ0030018 and miR-1236 Pathway
Isoliquiritigenin has potential antitumor effects by downregulating circ0030018 in glioma cells, reducing growth and invasion, and acting through the miR-1236/HER2 pathway, highlighting a promising therapeutic target.
RT @cancerscnews: In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not know…
In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not known. Researchers studied