MedComm (2020) June 2023 PMID 37250146

Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR-1236/HER2 signaling pathway.

Aiqun Liu, Baohong Jiang, Cailu Song, Qizhi Zhong, Yufan Mo, Ruiqin Yang, Ciyu Chen, Cheng Peng, Fu Peng, Hailin Tang

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Mentions

3
Peak: 2 in Jun 2023
across 2 sources since Jun 2023

Extended reach

4,067
potential audience

Total likes

2

Video views

47

Mentions per month

Jun 2023 – Oct 2023

Where it's discussed

  • X / Twitter2 posts
  • YouTube1 videos

AI synopsis

What people are saying

Overall, the discussions reflect a moderate level of support and curiosity, with references to both the antioxidant effects of isoliquiritigenin and the novel involvement of circRNA in glioma, evidenced by phrases like 'shows potential' and questions about the ISL-circRNA relationship. The tone combines cautious optimism with scientific curiosity, contributing to a balanced view of its potential impact.

AgreementModerate agreement

Most discussions acknowledge the potential of isoliquiritigenin in glioma treatment, indicating general agreement with the research's significance.

InterestModerate interest

Participants show moderate interest, often referencing the antioxidative and antitumor properties but expressing curiosity about the specific mechanisms.

EngagementModerate engagement

Comments include mention of research details, such as the role of circ0030018 and the miR-1236/HER2 pathway, suggesting active engagement.

ImpactModerate impact

The discussions recognize the potential for this research to impact future therapeutic strategies for glioma, highlighting its relevance.

Abstract in brief

  • Glioma is a common and aggressive brain tumor, and despite advancements in treatment, outcomes for high-risk patients remain inadequate.
  • Isoliquiritigenin (ISL) has shown potential antitumor and antioxidative effects, leading to the discovery that it downregulates circ0030018 in glioma cells.
  • Silencing circ0030018 reduces glioma cell growth and invasion, enhances oxidative stress, and functions partially through the miR-1236/HER2 signaling pathway, suggesting its potential as a therapeutic target.

Top posts

Most liked on X and Bluesky
Cancer Stem Cell News
@cancerscnews · X

In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not known. Researchers studied

Jun 4, 2023 · 2 likes · 1 share · 2,695 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @cancerscnews: In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not know…

Jun 4, 2023 · 1 share · 1,322 followers View post →

All mentions

Victoria Hendry
@HendryVictoria · X

RT @cancerscnews: In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not know…

Jun 4, 2023 · 1 share · 1,322 followers View post →
Cancer Stem Cell News
@cancerscnews · X

In #glioma, isoliquiritigenin (ISL) shows antioxidative and antitumor activities but ISL-circRNA relationship is not known. Researchers studied

Jun 4, 2023 · 2 likes · 1 share · 2,695 followers View post →