PubHawk
Clin Pharmacol Ther August 2023 PMID 37253161

Assessment of the Acute Effects of 2C-B vs. Psilocybin on Subjective Experience, Mood, and Cognition.

Pablo Mallaroni, Natasha L Mason, Johannes T Reckweg, Riccardo Paci, Sabrina Ritscher, Stefan W Toennes, Eef L Theunissen, Kim P C Kuypers, Johannes G Ramaekers

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Mentions

35
Peak: 10 in May 2023
across 3 sources since Feb 2023

Extended reach

212,731
potential audience

Total likes

200

Video views

5,988

Mentions per month

Feb 2023 – Jan 2025

Where it's discussed

  • X / Twitter31 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions reflect genuine curiosity and support for the study, with examples like mentions of 'outstanding neuroimaging data' and 'exciting findings,' showing a positive tone and engagement with the research's significance and methods.

AgreementModerate agreement

Most discussions express support or interest in the findings, with some tagging colleagues and celebrating the research, indicating general agreement with the significance of the study.

InterestHigh interest

Posts show high curiosity about the effects and implications of 2C-B versus psilocybin, reflected in comments about its duration, effects, and neuroimaging data.

EngagementModerate engagement

Some discussions cite specific aspects like neuroimaging, drug duration, and methodological steps, showing active engagement with detailed content.

ImpactModerate impact

The posts suggest the research advances understanding of psychedelics, especially regarding practical implications like duration and effects, indicating moderate impact on their fields.

Abstract in brief

  • This study compared the immediate effects of 2CB and psilocybin on mood, cognition, and heart rate in healthy experienced users, finding that both caused psychedelic-like changes, such as altered consciousness and affective states, with psilocybin producing more intense effects like ego dissolution.
  • Both substances slowed psychomotor performance and impaired spatial memory similarly, but neither increased empathy, and 2CB's effects lasted shorter (around 6 hours), with transient increases in blood pressure seen with both drugs.
  • The results suggest that 2CB should be considered a moderate psychedelic, with further research needed to understand how different doses affect its experience and pharmacokinetics.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Pablo Mallaroni
@PMallaroni · X

It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E18YZprgmi

May 31, 2023 · 41 likes · 9 shares · 289 followers View post →
Drummond E-Wen McCulloch
@D_E_McCulloch · X

Congratulations @PIMaastricht on their new study comparing 2CB, psilocybin and placebo (n=22). 2C-B effects lasted about 6 hours and seemed pretty similar to psilocybin. Exciting stuff, looking forward to trying to work out these differences in more detail https://t.co/mAjwAisZFQ

May 31, 2023 · 18 likes · 1 share · 1,821 followers View post →
Blossom
@blossomact · X

Mar 1, 2023 · 8 likes · 2 shares · 3,357 followers View post →
Eline Haijen
@ehaijen · X

@jomo137 Check out the paper by @PMallaroni and @PIMaastricht: https://t.co/0FYwhkBh6L

Jul 27, 2023 · 5 likes · 855 followers View post →
Bright Minds Biosciences
@brightmindsbio · X

New findings support the idea that 2C-B may be a psychedelic of moderate experiential depth. 2C-B subjective effects were similar to psilocybin while the self-reported effect duration was lower for 2C-B than Psilocybin. https://t.co/2dCMFbjAsO

Jun 8, 2023 · 4 likes · 5,894 followers View post →
Tommaso Barba
@tommaso_barba · X

@FundJls @PIMaastricht Here you are! https://t.co/iEMgEQPqJM

Jun 1, 2023 · 3 likes · 1 share · 4,641 followers View post →

All mentions

Synek
@2cSynek · X

@RCarhartHarris @KettnerHannes The ego dissolution as a negative predictor for adolesence makes sense, but still interesting. What are the implications? Better to stick to moderate doses? Maybe 2cb as a lighter headspace more predictable alternative? (https://t.co/p2PUQLe4TV)

Jan 18, 2025 · 29 followers View post →
Evgeny P
@yevgeny_pi · X

@agadelshin @humufan Это случается даже не на микродозах. К примеру в этом исследовании у них были нормальные дозы 2cb и псилоцибина и все равно один участник перепутал плацебо: https://t.co/XkLqAJNuZN

Sep 14, 2024 · 1 like · 84 followers View post →
Eline Haijen
@ehaijen · X

@jomo137 Check out the paper by @PMallaroni and @PIMaastricht: https://t.co/0FYwhkBh6L

Jul 27, 2023 · 5 likes · 855 followers View post →
UNITy
@PsychedelicUNIT · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

Jul 19, 2023 · 9 shares · 1,801 followers View post →
Natasha L Mason / nlmason.bsky.social
@NL_Mason · X

Sneak peaks of 2cb, neuroimaging data to come:https://t.co/M1GoGfCJgZ

Jun 29, 2023 · 2,131 followers View post →
Bright Minds Biosciences
@brightmindsbio · X

New findings support the idea that 2C-B may be a psychedelic of moderate experiential depth. 2C-B subjective effects were similar to psilocybin while the self-reported effect duration was lower for 2C-B than Psilocybin. https://t.co/2dCMFbjAsO

Jun 8, 2023 · 4 likes · 5,894 followers View post →
Psychopharmacology in Maastricht
@PIMaastricht · X

RT @YourBrainOnSci: 7. Assessment of the acute effects of #2CB vs #psilocybin on subjective experience, #mood and cognition by @PIMaastrich…

Jun 7, 2023 · 1 share · 2,811 followers View post →
Psychedelic Brain Science
@PsychedBrainSci · X

7. Assessment of the acute effects of #2CB vs #psilocybin on subjective experience, #mood and cognition by @PIMaastricht group #psychedelics #psychedelicexperience https://t.co/fcYzgHqTMJ

Jun 6, 2023 · 1 like · 1 share · 1,155 followers View post →
JLS Fund
@FundJls · X

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition https://t.co/8tWzBvgBAU Thanks for sharing this @tommaso_barba

Jun 5, 2023 · 298 followers View post →
Greg Cooper
@GregetarianC · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

Jun 2, 2023 · 9 shares · 940 followers View post →
デ力めの犬
@Lotus_Solus · X

2C-Bとシロシビンの比較。 シロシビンの代わりというか、ゴールドスタンダードになりそうな良さげな物質を探してるって感じなんかね。 Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition https://t.co/ntHnXKSbif

Jun 2, 2023 · 3 likes · 1,814 followers View post →
Ajna Jansson
@AjnaJansson · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

Jun 2, 2023 · 9 shares · 111 followers View post →
Tommaso Barba
@tommaso_barba · X

@FundJls @PIMaastricht Here you are! https://t.co/iEMgEQPqJM

Jun 1, 2023 · 3 likes · 1 share · 4,641 followers View post →
Franklin King MD
@KingFranklinIV · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

Jun 1, 2023 · 9 shares · 3,533 followers View post →
Tim Lawn
@lawn_tim · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

May 31, 2023 · 9 shares · 376 followers View post →
Evgeny P
@yevgeny_pi · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

May 31, 2023 · 9 shares · 84 followers View post →
Psychopharmacology in Maastricht
@PIMaastricht · X

RT @D_E_McCulloch: Congratulations @PIMaastricht on their new study comparing 2CB, psilocybin and placebo (n=22). 2C-B effects lasted about…

May 31, 2023 · 1 share · 2,811 followers View post →
Artur Czeszumski
@aczeszum · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

May 31, 2023 · 9 shares · 1,182 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

May 31, 2023 · 9 shares · 10,815 followers View post →
Psychopharmacology in Maastricht
@PIMaastricht · X

RT @PMallaroni: It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E…

May 31, 2023 · 9 shares · 2,811 followers View post →
Pablo Mallaroni
@PMallaroni · X

It be out! A struggle made poss by the wonderful people of @PIMaastricht Next step: task and rest fMRI ! https://t.co/E18YZprgmi

May 31, 2023 · 41 likes · 9 shares · 289 followers View post →
Drummond E-Wen McCulloch
@D_E_McCulloch · X

Congratulations @PIMaastricht on their new study comparing 2CB, psilocybin and placebo (n=22). 2C-B effects lasted about 6 hours and seemed pretty similar to psilocybin. Exciting stuff, looking forward to trying to work out these differences in more detail https://t.co/mAjwAisZFQ

May 31, 2023 · 18 likes · 1 share · 1,821 followers View post →
THERADELICS
@theradelics · X

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition https://t.co/D0MaWnpGyR https://t.co/QW8nFWRSOF

May 30, 2023 · 2 likes · 3,382 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition https://t.co/rOfJ8g3ljZ

May 30, 2023 · 1 like · 4,010 followers View post →
albertoeraso
@albertoeraso · X

RT @blossomact:

Mar 1, 2023 · 2 shares · 761 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

RT @blossomact:

Mar 1, 2023 · 2 shares · 738 followers View post →
Blossom
@blossomact · X

Overall, this study provides important insights into the subjective, cognitive, and cardiovascular effects of 2C-B compared to psilocybin, contributing to our understanding of the effects of novel psychedelics on human experience 6/6 https://t.co/NRJQfauknY

Mar 1, 2023 · 1 like · 3,357 followers View post →
Blossom
@blossomact · X

Mar 1, 2023 · 8 likes · 2 shares · 3,357 followers View post →
PromisingPreprints
@PromPreprint · X

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition https://t.co/GCAX8vEUVt

Feb 20, 2023 · 1 like · 3,308 followers View post →
Ythan
@Shroomery · X

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition https://t.co/WBRHNTVzJ5

Feb 17, 2023 · 1 like · 3,997 followers View post →
bioRxiv
@biorxivpreprint · X

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition https://t.co/MCEQYd35xd #bioRxiv

Feb 16, 2023 · 137,346 followers View post →