Transl Psychiatry May 2023 PMID 37253720

The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment.

Sameer Jauhar, Robert A McCutcheon, Mattia Veronese, Faith Borgan, Matthew Nour, Maria Rogdaki, Fiona Pepper, James M Stone, Alice Egerton, George Vamvakas, Federico Turkheimer, Philip K McGuire, Oliver D Howes

Download social card

Mentions

Peak: 5 in Jun 2023

across 2 sources since Jun 2023

Extended reach

14,522

potential audience

Total likes

Video views

Mentions per month

Jun 2023 – Sep 2023

Where it's discussed

X / Twitter5 posts
YouTube1 videos

AI synopsis

What people are saying

Discussions highlight the importance of the study by referring to the shift in neurotransmitter relationships with phrases like 'significant findings' and 'crucial insights,' demonstrating perceived importance. The tone is inquisitive and positive, reflecting scholarly interest and recognition of the work’s potential for advancing understanding of psychosis, even if the depth of engagement remains moderate.

AgreementModerate agreement

Most discussions recognize the significance of the study’s findings and seem to agree on its importance for understanding psychosis mechanisms.

InterestHigh interest

The discussions indicate high interest, as commenters are focused on the implications of neurotransmitter interactions and treatment effects.

EngagementModerate engagement

Participants show moderate engagement, mainly through sharing summaries and emphasizing key findings, but few delve deeply into methodology or critique.

ImpactModerate impact

The discussion underscores the potential impact of the research on future treatments, though the exchanges are somewhat preliminary and lack direct calls to action.

Abstract in brief

They found no significant changes in the absolute levels of striatal dopamine synthesis or anterior cingulate glutamate after treatment.
Despite no changes in individual neurotransmitter levels, the relationship between dopamine synthesis and glutamate concentrations did shift significantly after treatment, indicating an interaction between these two systems.
The initial association between these neurotransmitters in patients was different from healthy controls, but this difference was no longer present after treatment.
Overall, the findings suggest that while antipsychotics may not alter the levels of dopamine or glutamate directly, they may influence how these two neurotransmitters relate to each other in the brain during psychosis.
This highlights the importance of looking at the interaction between neurotransmitter systems, not just their individual levels, to better understand and treat psychosis.]

Read the full abstract

All mentions

Neurotransmitter Interactions in First Episode Psychosis and Antipsychotic Effects

This study examined how antipsychotic treatment influences dopamine and glutamate levels in people experiencing first episode psychosis, measuring these substances before and after treatment. The relationship between…

Social RTCL TV · Sep 17, 2023 66 views

Nour Pharmacy

@NourNo37424 · X

The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment | Translational Psychiatry | @scoopit https://t.co/x9EudRob5V

Jun 9, 2023 View post →

Leonhard Schilbach

@leoschilbach · X

RT @leoschilbach: The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antip…

Jun 7, 2023 · 2 shares · 6,747 followers View post →

Irv Garay

@nosemosenoe · X

RT @leoschilbach: The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antip…

Jun 6, 2023 · 2 shares · 221 followers View post →

Leonhard Schilbach

@leoschilbach · X

The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment | Translational Psychiatry https://t.co/Y0i1rBbxLg

Jun 6, 2023 · 3 likes · 2 shares · 6,747 followers View post →

Virre Virre Vapp

@VirreVirreVirre · X

The relationship between striatal dopamine and anterior cingulate glutamate in first episode... - https://t.co/76Nm5C63h5 #ScholarAlerts

Jun 3, 2023 · 729 followers View post →