Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis.

Abstract in brief

• This study used network meta-analysis to compare the effectiveness of different probiotic supplements used alongside standard triple therapy for Helicobacter pylori eradication, finding that certain probiotics such as Bifidobacterium, Lactobacillus, and Saccharomyces showed higher eradication rates and fewer side effects.
• Results from 34 randomized controlled trials involving over 9,000 patients indicated that adding probiotics generally improved treatment outcomes, with combinations like Bifidobacterium and Lactobacillus being particularly effective in boosting eradication rates (~78-88%) and reducing adverse effects.
• The research suggests that combining specific probiotics with triple therapy, especially Bifidobacterium and Lactobacillus, can be a better strategy to enhance eradication success and protect against side effects, making these probiotics a recommended addition in H. pylori treatment.