Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies.

Abstract in brief

• The p53 tumor suppressor pathway plays a crucial role in regulating the cell cycle, DNA repair, metabolism, angiogenesis, and apoptosis in response to stress, with its activity being tightly controlled through modifications like phosphorylation, acetylation, and ubiquitination.
• Abnormal activation or inactivation of p53 is closely linked to cancer development, but targeted therapies focusing on this pathway are still in early stages, with few treatments in clinical trials; ongoing research aims to develop effective drugs.
• Recent studies highlight TRIAP1 as a key downstream inhibitor of p53-mediated apoptosis that promotes tumor growth, making it a promising target for future cancer therapies.]