Nat Commun May 2023 PMID 37258531

Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy.

Marjan M Naeini, Felicity Newell, Lauren G Aoude, Vanessa F Bonazzi, Kalpana Patel, Guy Lampe, Lambros T Koufariotis, Vanessa Lakis, Venkateswar Addala, Olga Kondrashova, Rebecca L Johnston, Sowmya Sharma, Sandra Brosda, Oliver Holmes, Conrad Leonard

Full text PDF Download social card

Mentions

Peak: 2 in Oct 2023

across 2 sources since Jun 2023

Extended reach

128

potential audience

Total likes

Video views

Mentions per month

Jun 2023 – Oct 2023

Where it's discussed

X / Twitter2 posts
YouTube1 videos

AI synopsis

What people are saying

Discussions highlight interest in the study's detailed genetic and immune analyses, with posts referencing features like APOBEC mutations and immune clusters to emphasize its potential to improve patient outcomes. The tone varies from analytical to optimistic, reflecting both curiosity and recognition of the study's significance.

AgreementModerate agreement

Most discussions acknowledge the value of the research, with some expressing optimism about its implications for treatment outcomes.

InterestHigh interest

The posts show high curiosity, particularly about the genomic and immune profiling insights, indicating strong engagement with the topic.

EngagementModerate engagement

Several discussions include references to specific molecular features and potential clinical applications, suggesting moderate depth.

ImpactModerate impact

Participants believe the findings could influence future research directions and treatment strategies, though some see it as preliminary.

Abstract in brief

Oesophageal adenocarcinoma often has a poor prognosis, and this study examines genetic and molecular data from 115 patients to understand treatment responses better.
The researchers found specific genomic features, like the APOBEC mutation and RS3-like rearrangements, that are linked to shorter survival times, while non-responding patients showed more complex genomic alterations.
Patients were categorized into four immune clusters based on their transcriptomic data, revealing that those in the immune suppressed cluster had worse survival outcomes, while those in the immune hot cluster showed better survival and characteristics that suggest potential responsiveness to immunotherapy.

Read the full abstract

All mentions

Genomic and Immune Features of Oesophageal Adenocarcinoma Post-Treatment

This study investigates genetic and molecular data from 115 patients with oesophageal adenocarcinoma to understand treatment responses. It highlights specific genomic features linked to survival and identifies immune…

STEM RTCL TV · Oct 1, 2023 41 views

LungCancer

@LungCan78725393 · X

Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperati… | https://t.co/NMrLrnwdIc [Video] https://t.co/zsFixcq0oF

Oct 7, 2023 · 16 followers View post →

minnlab_litbot

@MLitbot · X

Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy https://t.co/hQ2SJ9e8EF https://t.co/IfgsjJTcs8

Jun 1, 2023 · 72 followers View post →