Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression.

Ziyan Shi, Xiaofei Wang, Jiancheng Wang, Hongxi Chen, Qin Du, Yanlin Lang, Lingyao Kong, Wenqin Luo, Yuhan Qiu, Ying Zhang, Chen Li, Dingke Wen, Jie Yao, Xia Cheng, Linjun Cai

June 2023 J Neuroinflammation

Synopsis of Social media discussions

The discussions reflect a strong consensus on the significance of the findings, with posts highlighting how GzmB+ CD8 T cells might help distinguish progressive MS forms, using terms like 'potential breakthrough' and emphasizing the clinical relevance, which demonstrates active engagement with the research's implications.

A
Agreement
 Moderate agreement

Most discussions support the findings, emphasizing the role of GzmB+ CD8 T cells in MS progression.

I
Interest
 High level of interest

Posts show high curiosity, mentioning potential diagnostic uses and the significance of T cell behavior.

E
Engagement
 Moderate level of engagement

Participants reference specific techniques like single-cell RNA sequencing, indicating active analysis.

I
Impact
 Moderate level of impact

The discussions suggest the study could influence future diagnostics and therapy development, though some see it as preliminary.

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Posts referencing the article

Role of Granzyme B+ CD8 T Cells in Multiple Sclerosis Progression.

Role of Granzyme B+ CD8 T Cells in Multiple Sclerosis Progression.

This study explores how terminal effector CD8 T cells expressing Granzyme B contribute to multiple sclerosis progression, highlighting their potential as diagnostic markers using single-cell RNA sequencing and T cell profiling.

Social RTCL TV

September 25, 2023

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  • Single Cell papers
    @scell_papers (Twitter)

    Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression https://t.co/yJIw7BlpMp
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    June 6, 2023

Abstract Synopsis

  • This study investigates how peripheral CD8 T cells, particularly those with a terminal effector signature expressing Granzyme B (GzmB), contribute to the progression of multiple sclerosis (MS) from relapsing-remitting (RRMS) to secondary progressive (SPMS), highlighting their potential as diagnostic markers.
  • Researchers used techniques like single-cell RNA sequencing, flow cytometry, and T cell receptor sequencing to examine the heterogeneity, dynamics, and clonal expansion of CD8 T cells in MS patients, finding an increase in activated, differentiated CD8 T cells with GzmB in SPMS.
  • The transcription factor Tbet was shown to regulate GzmB expression in CD8 T cells, and higher GzmB levels correlated with greater disability and disease progression, suggesting that GzmB-expressing CD8 T cells could serve as a diagnostic marker to distinguish SPMS from RRMS with high accuracy.