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Nat Commun June 2023 PMID 37270547

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition.

Mattia Zaghi, Federica Banfi, Luca Massimino, Monica Volpin, Edoardo Bellini, Simone Brusco, Ivan Merelli, Cristiana Barone, Michela Bruni, Linda Bossini, Luigi Antonio Lamparelli, Laura Pintado, Deborah D'Aliberti, Silvia Spinelli, Luca Mologni

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Mentions

8
Peak: 4 in Jun 2023
across 2 sources since Sep 2022

Extended reach

148,009
potential audience

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0

Video views

9

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Sep 2022 – Oct 2023

Where it's discussed

  • X / Twitter7 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions demonstrate enthusiasm and curiosity about the role of SET in enhancer regulation, referencing specific elements like acetylation and CTCF sites, with tone emphasizing the significance of maintaining correct chromatin states for cell fate decisions, which underscores the perceived importance and potential impact of the research.

AgreementModerate agreement

Most discussions seem to agree that maintaining balanced SET levels is important for proper enhancer function during cell differentiation.

InterestHigh interest

The posts show high interest in the scientific methodology and implications, with mentions of acetylation, enhancer specificity, and chromatin interactions.

EngagementModerate engagement

Participants reference key concepts like enhancer repertoire and chromatin marks, indicating a moderate level of engagement beyond surface-level mentions.

ImpactModerate impact

Discussion around the article’s findings highlights its potential influence on understanding gene regulation and disorders involving SET, suggesting it could impact future research directions.

Abstract in brief

  • Chromatin interactions between distal elements and promoters are crucial for regulating gene transcription, influenced by histone acetylation.
  • The oncoprotein SET plays a significant role in histone acetylation at enhancers, especially in the context of Schinzel-Giedion Syndrome (SGS), where its accumulation disrupts normal regulatory processes.
  • This disruption leads to the use of alternative enhancers and changes in gene transcription, representing a maladaptive mechanism that can influence cell differentiation and maturation in SET-related disorders.
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Top posts

Most liked on X and Bluesky
bioRxiv
@biorxivpreprint · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition https://t.co/eTosBPP3Ih #bioRxiv

Sep 13, 2022 · 136,953 followers View post →
Nucleosome papers
@Nucleosome_Bot · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition https://t.co/gG1GIogQMO

Jun 4, 2023 · 4,709 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition. Nat Commun. 2023; 14: 3212. Published online 2023 Jun 3. doi: 10.1038/s41467-023-39043-x https://t.co/TGHmGhumNF https://t.co/gUONgzLjcz

Jun 5, 2023 · 2,046 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition. Since these enhancers are marked by Acetylation, they are most likely to encompass double (2xCTS) rather than single CTCF target sites. Nat Commun. 06/03/2023 https://t.co/6ba7MG9UIE https://t.co/D8BTInTWDP https://t.co/AmucbVKytC

Jun 5, 2023 · 2,046 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition. Since these enhancers are marked by Acetylation, they are most likely to encompass double (2xCTS) rather than single CTCF target sites. Nat Commun. 06/03/2023 https://t.co/6ba7MGasyc https://t.co/bCrRTLKXHB

Jul 21, 2023 · 2,046 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Nature Communications paper "Balanced SET levels favor the correct enhancer rep…" (https://t.co/l4PrbV5Qz6). Thank you for making your #methodsmatter. #OpenScience

Jun 23, 2023 · 161 followers View post →

All mentions

Victor V. Lobanenkov
@boris_ctcf · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition. Since these enhancers are marked by Acetylation, they are most likely to encompass double (2xCTS) rather than single CTCF target sites. Nat Commun. 06/03/2023 https://t.co/6ba7MGasyc https://t.co/bCrRTLKXHB

Jul 21, 2023 · 2,046 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Nature Communications paper "Balanced SET levels favor the correct enhancer rep…" (https://t.co/l4PrbV5Qz6). Thank you for making your #methodsmatter. #OpenScience

Jun 23, 2023 · 161 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition. Since these enhancers are marked by Acetylation, they are most likely to encompass double (2xCTS) rather than single CTCF target sites. Nat Commun. 06/03/2023 https://t.co/6ba7MG9UIE https://t.co/D8BTInTWDP https://t.co/AmucbVKytC

Jun 5, 2023 · 2,046 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition. Nat Commun. 2023; 14: 3212. Published online 2023 Jun 3. doi: 10.1038/s41467-023-39043-x https://t.co/TGHmGhumNF https://t.co/gUONgzLjcz

Jun 5, 2023 · 2,046 followers View post →
Nucleosome papers
@Nucleosome_Bot · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition https://t.co/gG1GIogQMO

Jun 4, 2023 · 4,709 followers View post →
Biorxiv Reddit
@BiorxivReddit · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition https://t.co/CUuzUrparx

Sep 13, 2022 · 39 followers View post →
bioRxiv
@biorxivpreprint · X

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition https://t.co/eTosBPP3Ih #bioRxiv

Sep 13, 2022 · 136,953 followers View post →