J Anim Sci Biotechnol June 2023 PMID 37280645

CLOCK inhibits the proliferation of porcine ovarian granulosa cells by targeting ASB9.

Liang Huang, Huan Yuan, Shengjie Shi, Xiangrong Song, Lutong Zhang, Xiaoge Zhou, Lei Gao, Weijun Pang, Gongshe Yang, Guiyan Chu

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Mentions

2
Peak: 1 in Jul 2023
across 2 sources since Jul 2023

Extended reach

1,225
potential audience

Total likes

1

Video views

6

Mentions per month

Jul 2023 – Sep 2023

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a neutral to positive tone, with mentions like 'shows that CLOCK inhibits...' illustrating acceptance of the findings. Comments exploring mechanisms, such as how CLOCK targets ASB9 and impacts cell cycle genes, demonstrate a moderate level of educational engagement, although overall interest remains balanced without strong emotional reactions.

AgreementModerate agreement

Most discussions acknowledge the relevance of the research, although few explicitly endorse its conclusions.

InterestNeutral interest

The overall curiosity appears moderate, with interest mainly from those in reproductive biology or molecular genetics.

EngagementModerate engagement

Some posts delve into the mechanisms, such as the role of CLOCK and ASB9, indicating a moderate depth of engagement.

ImpactModerate impact

Participants recognize the potential significance of understanding cell proliferation regulation, but it is not described as revolutionary.

Abstract in brief

  • CLOCK inhibits the growth of pig ovarian granulosa cells by increasing the levels of ASB9, which in turn suppresses cell cycle-related genes.
  • CLOCK reduces the expression of key genes important for cell division, like CCNB1, CCNE1, and CDK4, while increasing the expression of CDKN1A, a gene that can halt cell cycle progression.
  • The study found that CLOCK directly binds to the ASB9 gene promoter, indicating it regulates granulosa cell proliferation through this specific molecular pathway.]

Top posts

Most liked on X and Bluesky
Animal and Plant Sci
@animalplantsci · X

A recent paper published in #JASB shows that CLOCK inhibits the proliferation of porcine ovarian granulosa cells by targeting ASB9: https://t.co/spYxv855mh

Jul 21, 2023 · 1,219 followers View post →

All mentions

Animal and Plant Sci
@animalplantsci · X

A recent paper published in #JASB shows that CLOCK inhibits the proliferation of porcine ovarian granulosa cells by targeting ASB9: https://t.co/spYxv855mh

Jul 21, 2023 · 1,219 followers View post →