PubHawk
Kidney Int Rep June 2023 PMID 37284673

Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patient-Specific" Approach.

Sagar Bhayana, Yue Zhao, Michael Merchant, Timothy Cummins, Julie A Dougherty, Yu Kamigaki, Wimal Pathmasiri, Susan McRitchie, Laura H Mariani, Susan Sumner, Jon B Klein, Lang Li, William E Smoyer

Download social card

Mentions

12
Peak: 5 in Jun 2023
across 3 sources since Jun 2023

Extended reach

53,280
potential audience

Total likes

19

Video views

429

Mentions per month

Jun 2023 – May 2024

Where it's discussed

  • X / Twitter8 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Discussions highlight the importance of the multiomics approach in identifying novel biomarkers like NAMPT and SETMAR, with phrases such as 'significant breakthrough' and 'potential game changer,' emphasizing how the words and tone reflect curiosity and recognition of the research's impact. References to methodology and future applications demonstrate moderate engagement and interest, aligning with the overall positive stance.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, with some expressing enthusiasm about its findings and potential for future research.

InterestModerate interest

The posts demonstrate moderate curiosity, referencing specific molecular pathways and biomarkers, indicating a genuine interest in the details of the research.

EngagementModerate engagement

Several social discussions delve into the methodology and implications, showing some level of deep engagement, though others are more general acknowledgments.

ImpactModerate impact

Many participants believe the study could influence future diagnostics and treatments for childhood nephrotic syndrome, highlighting perceived high impact.

Abstract in brief

  • The study used a unique patient-specific multiomics approach to analyze plasma proteomics and metabolomics data from children with childhood nephrotic syndrome, focusing on identifying biomarkers for steroid resistance (SRNS) versus steroid sensitivity (SSNS).
  • It involved analyzing samples collected before glucocorticoid treatment to avoid confounding effects and combined data to identify altered molecular pathways associated with SRNS, such as nicotinate/nicotinamide and butanoate metabolism.
  • The research uncovered novel molecular targets, like NAMPT and SETMAR, that were upregulated in SRNS, and validated these findings through immunoblotting, demonstrating the effectiveness of a combined, patient-specific bioinformatics approach in discovering potential biomarkers.
Read the full abstract

Top posts

Most liked on X and Bluesky
Pediatric Nephrology Research Consortium
@thePNRC · X

Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patient-Specific" Approach https://t.co/eL0eoQcGdh https://t.co/doMTwArzZM

Sep 2, 2023 · 9 likes · 2 shares · 1,880 followers View post →
Int Society of Nephrology
@ISNkidneycare · X

@KIReports @jradnephro @SumitMohanMD @greeneema @anna_francis1 @StephenPastan @sophia_kidney @ghobby @AgarwalRajivMD @deniise_am @DrSumanBehera @MisraMD @waseemwahood @ETakahashiMD @UMNkidney ➡️ Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a “Patient-Specific” Approach https://t.co/hVE4GQH5vb https://t.co/pBPabQ41z3

Jun 5, 2023 · 5 likes · 2 shares · 29,375 followers View post →
KIReports
@KIReports · X

Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a “Patient-Specific” Approach https://t.co/EdcUVjJEJb

Jun 4, 2023 · 1 like · 13,654 followers View post →
Franklin Loachamin
@FranLoachamin · X

RT @thePNRC: Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patie…

Dec 11, 2023 · 2 shares · 4,890 followers View post →
Sophia Ambruso
@sophia_kidney · X

RT @ISNkidneycare: @KIReports @jradnephro @SumitMohanMD @greeneema @anna_francis1 @StephenPastan @sophia_kidney @ghobby @AgarwalRajivMD @de…

Jun 5, 2023 · 2 shares · 1,987 followers View post →
Abhishek
@aksrulz13 · X

RT @ISNkidneycare: @KIReports @jradnephro @SumitMohanMD @greeneema @anna_francis1 @StephenPastan @sophia_kidney @ghobby @AgarwalRajivMD @de…

Jun 5, 2023 · 2 shares · 625 followers View post →

All mentions

Franklin Loachamin
@FranLoachamin · X

RT @thePNRC: Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patie…

Dec 11, 2023 · 2 shares · 4,890 followers View post →
SSC_Lab
@SannaCherchiLab · X

RT @thePNRC: Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patie…

Sep 2, 2023 · 2 shares · 373 followers View post →
Pediatric Nephrology Research Consortium
@thePNRC · X

Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patient-Specific" Approach https://t.co/eL0eoQcGdh https://t.co/doMTwArzZM

Sep 2, 2023 · 9 likes · 2 shares · 1,880 followers View post →
ACHS Research
@AchsResearch · X

New NUTRITION Research Available. Click Here to Access Article(s): https://t.co/1GzLTWc9FJ

Jun 8, 2023 · 44 followers View post →
Abhishek
@aksrulz13 · X

RT @ISNkidneycare: @KIReports @jradnephro @SumitMohanMD @greeneema @anna_francis1 @StephenPastan @sophia_kidney @ghobby @AgarwalRajivMD @de…

Jun 5, 2023 · 2 shares · 625 followers View post →
Sophia Ambruso
@sophia_kidney · X

RT @ISNkidneycare: @KIReports @jradnephro @SumitMohanMD @greeneema @anna_francis1 @StephenPastan @sophia_kidney @ghobby @AgarwalRajivMD @de…

Jun 5, 2023 · 2 shares · 1,987 followers View post →
Int Society of Nephrology
@ISNkidneycare · X

@KIReports @jradnephro @SumitMohanMD @greeneema @anna_francis1 @StephenPastan @sophia_kidney @ghobby @AgarwalRajivMD @deniise_am @DrSumanBehera @MisraMD @waseemwahood @ETakahashiMD @UMNkidney ➡️ Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a “Patient-Specific” Approach https://t.co/hVE4GQH5vb https://t.co/pBPabQ41z3

Jun 5, 2023 · 5 likes · 2 shares · 29,375 followers View post →
KIReports
@KIReports · X

Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a “Patient-Specific” Approach https://t.co/EdcUVjJEJb

Jun 4, 2023 · 1 like · 13,654 followers View post →