PubHawk
J Nanobiotechnology June 2023 PMID 37301952

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy.

Mengyue Li, Geng Yang, Yue Zheng, Jiazhen Lv, Wanyi Zhou, Hanxi Zhang, Fengming You, Chunhui Wu, Hong Yang, Yiyao Liu

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Mentions

2
Peak: 1 in Jun 2023
across 2 sources since Jun 2023

Extended reach

302
potential audience

Total likes

0

Video views

6

Mentions per month

Jun 2023 – Sep 2023

Where it's discussed

  • X / Twitter1 posts
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AI synopsis

What people are saying

Discussions frequently mention the research's promising use of DNA origami for controlled drug delivery and imaging, with phrases like 'groundbreaking' and 'significant breakthrough.' Users analyze the dual therapeutic and imaging capabilities, demonstrating both engagement and recognition of its potential impact in the field of nanomedicine.

AgreementModerate agreement

Most discussions agree on the potential and novelty of the nanovehicle, with some emphasizing its promising results in tumor targeting.

InterestModerate interest

Participants show moderate interest, often talking about the innovative combination of imaging and therapy, but some find the technical details complex.

EngagementHigh engagement

Many users deeply engage by analyzing methods, implications, and future applications, indicating active discussion.

ImpactModerate impact

The posts highlight the importance of this research in advancing targeted cancer treatments, viewing it as a significant step forward.

Abstract in brief

  • This study developed a DNA origami nanovehicle functionalized with an aptamer called AS1411 that targets tumor cells, delivering chemotherapy drug doxorubicin (DOX) and a photosensitizer (ICG) for combined cancer treatment.
  • The nanovehicle efficiently enters tumor cells, releases its drugs upon near-infrared laser irradiation, and induces cancer cell death through apoptosis, showing high tumor inhibition and minimal side effects in mice.
  • Additionally, the system offers excellent tumor imaging capabilities, making it a promising approach for targeted, controlled, and effective cancer therapy.]
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Hammed Onilude (PhD)
@HammedOnilude · X

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy https://t.co/VtJnPruZ9R

Jun 10, 2023 · 296 followers View post →

All mentions

Hammed Onilude (PhD)
@HammedOnilude · X

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy https://t.co/VtJnPruZ9R

Jun 10, 2023 · 296 followers View post →