Aging (Albany NY) June 2023 PMID 37315204

Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery.

Anatoly Urban, Denis Sidorenko, Diana Zagirova, Ekaterina Kozlova, Aleksandr Kalashnikov, Stefan Pushkov, Vladimir Naumov, Viktoria Sarkisova, Geoffrey Ho Duen Leung, Hoi Wing Leung, Frank W Pun, Ivan V Ozerov, Alex Aliper, Feng Ren, Alex Zhavoronkov

Mentions

15
Peak: 14 in Jun 2023
across 4 sources since Jun 2023

Extended reach

127,095
potential audience

Total likes

36

Video views

851

Mentions per month

Jun 2023 – May 2025

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos
  • News2 articles
  • Blogs1 articles

AI synopsis

What people are saying

Participants express strong interest and moderate engagement by discussing the technical advancements and potential applications of Precious1GPT, using phrases like 'target discovery' and 'aging clock development' to emphasize its scientific and therapeutic relevance. Their tone suggests they see this research as impactful for future aging and medical interventions.

AgreementModerate agreement

Most discussions recognize the significance of Precious1GPT in advancing aging research, indicating general support and agreement with its potential.

InterestHigh interest

The multiple references to the publication and focus on innovative methods show high interest from the community.

EngagementModerate engagement

Participants engage by sharing summaries, reactions, and highlighting key features, reflecting moderate to deep involvement.

ImpactModerate impact

The emphasis on potential for therapeutic discovery and innovation suggests the discussions see a meaningful influence of the work in the field.

Abstract in brief

  • The study introduces Precious1GPT, a new multimodal aging clock that uses both methylation and transcriptomic data to predict biological age and identify potential therapeutic targets, addressing the limitations of existing aging clocks that are often specialized and disconnected.
  • Although Precious1GPT's accuracy in predicting age is slightly lower than specialized clocks, it offers greater potential for discovering new therapeutic targets by analyzing features important for aging and age-related diseases, which could lead to interventions that modify biological age.
  • The researchers also used the PandaOmics platform to annotate and identify promising targets, providing a pathway for drug discovery and validation aimed at reversing or accelerating biological aging.

Top posts

Most liked on X and Bluesky
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

New Paper Alert: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery We developed a multi-modal epigenetic and transcriptomic clock that can be used for target https://t.co/hq9cERhVOC

Jun 15, 2023 · 20 likes · 3 shares · 33,095 followers View post →
Peter Xing
@peterxing · X

Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery | Aging https://t.co/uqWGMPYmo8

Jun 16, 2023 · 5 likes · 1 share · 24,518 followers View post →
Biomarkers of Aging Consortium
@agingbiomarkers · X

New paper by Consortium member @biogerontology and colleagues on Precious1GPT, a multimodal transformer-based transfer learning for #aging clock development and feature importance analysis for aging and age-related disease target discovery. https://t.co/wmogCsynJ5

Jun 18, 2023 · 5 likes · 1 share · 2,432 followers View post →
Agingdoc
@agingdoc1 · X

Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery Anatoly Urban, @biogerontology & coauthors. https://t.co/PC5Y1edrfJ @AgingJrnl https://t.co/g8ZIBtqROO

Jun 15, 2023 · 3 likes · 1 share · 43,746 followers View post →
Transhumanism Australia
@transhumanAU · X

RT @peterxing: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for…

Jun 16, 2023 · 1 share · 18,503 followers View post →
Kejun (Albert) Ying
@KejunYing · X

RT @biogerontology: New Paper Alert: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature i…

Jun 15, 2023 · 3 shares · 2,248 followers View post →

All mentions

Biomarkers of Aging Consortium
@agingbiomarkers · X

New paper by Consortium member @biogerontology and colleagues on Precious1GPT, a multimodal transformer-based transfer learning for #aging clock development and feature importance analysis for aging and age-related disease target discovery. https://t.co/wmogCsynJ5

Jun 18, 2023 · 5 likes · 1 share · 2,432 followers View post →
Transhumanism Australia
@transhumanAU · X

RT @peterxing: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for…

Jun 16, 2023 · 1 share · 18,503 followers View post →
Peter Xing
@peterxing · X

Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery | Aging https://t.co/uqWGMPYmo8

Jun 16, 2023 · 5 likes · 1 share · 24,518 followers View post →
Arne Søraas
@ArSoraas · X

RT @biogerontology: New Paper Alert: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature i…

Jun 16, 2023 · 3 shares · 257 followers View post →
Kejun (Albert) Ying
@KejunYing · X

RT @biogerontology: New Paper Alert: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature i…

Jun 15, 2023 · 3 shares · 2,248 followers View post →
Carles Villaplana
@carlesvillapla1 · X

RT @biogerontology: New Paper Alert: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature i…

Jun 15, 2023 · 3 shares · 368 followers View post →
Jay
@jckellyinc · X

https://t.co/Lee6SbI174

Jun 15, 2023 · 27 followers View post →
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology · X

New Paper Alert: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery We developed a multi-modal epigenetic and transcriptomic clock that can be used for target https://t.co/hq9cERhVOC

Jun 15, 2023 · 20 likes · 3 shares · 33,095 followers View post →
J Sam
@JaicSam · X

RT @agingdoc1: Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for…

Jun 15, 2023 · 1 share · 987 followers View post →
Agingdoc
@agingdoc1 · X

Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery Anatoly Urban, @biogerontology & coauthors. https://t.co/PC5Y1edrfJ @AgingJrnl https://t.co/g8ZIBtqROO

Jun 15, 2023 · 3 likes · 1 share · 43,746 followers View post →
Novel approach to multimodal aging clock for interpretable age ...
Blogs

... aging and age-related disease target discovery. Aging-US. doi.org/10.18632/aging.204788. Be the first to rate this article. Posted in: Drug ...

Jun 21, 2023 View →
Precious1GPT: multimodal transfer learning for aging clock ...
News

... aging.” Read the full study: DOI: https://doi.org/10.18632/aging.204788. Corresponding Author: Alex Zhavoronkov. Corresponding Email: alex ...

Jun 20, 2023 View →
英矽智能发布基于Transformer模型的衰老时钟,赋能抗衰老和疾病的 ...
News

... aging and age-related disease target discovery. Aging (Albany NY). 2023 Jun 13; . https://doi.org/10.18632/aging.204788 [Epub ahead of print].

Jun 15, 2023 View →