Nat Commun June 2023 PMID 37328472

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.

Katherine U Gaynor, Marina Vaysburd, Maximilian A J Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul Brear, Aleksei Lulla, Katarzyna Ciazynska

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Mentions

Peak: 16 in Jul 2023

across 2 sources since Jun 2023

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522,786

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Jun 2023 – Sep 2023

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X / Twitter26 posts
YouTube1 videos

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What people are saying

The overall tone reflects high enthusiasm about the breakthrough, with posts highlighting the peptide's effectiveness against SARS-CoV-2 and its potential as a new antiviral approach. Words like 'potent' and mentions of organizations such as @NatureComms and #WellcomeTrust underscore both the scientific promise and broad interest in this development.

AgreementStrong agreement

Most discussions praise the findings, emphasizing the effectiveness and potential of multivalent bicyclic peptides against COVID-19, using words like 'effective' and 'potently inhibit'.

InterestHigh interest

Posts show high interest, with numerous hashtags, mentions of related fields like virology and drug discovery, and references to prominent organizations, indicating curiosity and relevance.

EngagementModerate engagement

Users engage by sharing enthusiasm, retweeting from reputable sources, and emphasizing the significance of this research, although some posts are more promotional than analytical.

ImpactHigh impact

Discussion suggests the research could significantly influence antiviral strategies, with phrases like 'new antiviral modality' and references to potential therapeutic applications enhancing its perceived importance.

Abstract in brief

COVID-19 has led to the swift creation of new antiviral treatments, including a novel approach using "Bicycles," which are specially structured peptides that target SARS-CoV-2.
By screening bacteriophage libraries, researchers identified specific Bicycle binders that were enhanced from micromolar to nanomolar efficacy through a process called multimerization.
Testing in mouse models showed that these multimerized and biparatopic Bicycles effectively reduce viral load and inflammation, highlighting their potential as a new antiviral strategy against evolving viruses like SARS-CoV-2.

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Multivalent Bicyclic Peptides as Potent SARS-CoV-2 Inhibitors

This video discusses the development of multivalent bicyclic peptides as a new antiviral approach against SARS-CoV-2, demonstrating their enhanced efficacy through multimerization and promising results in mouse models.

STEM RTCL TV · Sep 30, 2023 36 views

Loic Carrique

@CarriqueLoic · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Aug 23, 2023 · 12 shares · 502 followers View post →

Ieva Drulyte

@IevaDrulyte · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Aug 22, 2023 · 12 shares · 2,105 followers View post →

Utrecht Virology Lab

@UtrechtVirology · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Aug 22, 2023 · 12 shares · 2,194 followers View post →

Blair Strang

@StrangVirusLab · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Aug 21, 2023 · 12 shares · 1,019 followers View post →

Leo James' Lab

@JamesLab9 · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Aug 21, 2023 · 12 shares · 981 followers View post →

김연수

@dEmeZE976ZJpXBH · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 14, 2023 · 12 shares · 10 followers View post →

Phelipe Vitale

@VitalePhelipe · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 14, 2023 · 12 shares · 24 followers View post →

npj Antimicrobials and Resistance

@npjAMR · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 14, 2023 · 12 shares · 1,298 followers View post →

Ciudadano común y corriente

@TwiteroDeVisera · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 14, 2023 · 12 shares · 737 followers View post →

Nick Fuller

@nick_full3r · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 14, 2023 · 12 shares · 311 followers View post →

Lucile Mollet

@MolletLucile · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 14, 2023 · 12 shares · 396 followers View post →

Nature Communications

@NatureComms · X

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19 #virology #DrugDiscovery https://t.co/e3aIjgmuP3 https://t.co/yjSXMx4UEJ

Jul 14, 2023 · 37 likes · 12 shares · 248,521 followers View post →

Phenomics

@Phenomics_J · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 12, 2023 · 9 shares · 1,528 followers View post →

from_atoms_to_stars

@akitaelperro · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 11, 2023 · 9 shares · 72 followers View post →

Steve Burston

@BurstonSteven · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 11, 2023 · 9 shares · 498 followers View post →

John Kenten

@JohnKenten · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 11, 2023 · 9 shares · 577 followers View post →

#cisplatin

@cisplatin7 · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 11, 2023 · 9 shares · 798 followers View post →

Anthony Rullo: chemically modulating proximity

@LabRullo · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 11, 2023 · 9 shares · 933 followers View post →

Rob Field, PVC Science, UEA

@Rob_Field_Lab · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 11, 2023 · 9 shares · 3,450 followers View post →

Quod scripsi, scripsi

@2lcrs6 · X

RT @NatureComms: Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19…

Jul 11, 2023 · 9 shares · 188 followers View post →

Nature Communications

@NatureComms · X

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19 #virology #DrugDiscovery https://t.co/e3aIjgn2EB https://t.co/8OdXXzoa7F

Jul 11, 2023 · 36 likes · 9 shares · 248,521 followers View post →

Diamond MX Beamlines

@Diamond_MX · X

New Paper from I04 in @NatureComms https://t.co/eD2vcmTAXe (https://t.co/ds8vKMDBmf)

Jun 29, 2023 · 1,420 followers View post →

Europe PMC articles

@EuropePMC · X

New from #The_MRC https://t.co/35sfokJgMC Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.

Jun 20, 2023 · 1,552 followers View post →

Europe PMC articles

@EuropePMC · X

New from #wellcometrust https://t.co/35sfokJgMC Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.

Jun 20, 2023 · 1,552 followers View post →

Alberto Román

@alberto_roman83 · X

1️⃣ Published: 16 June 2023 Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 https://t.co/ubkQV0HnPO

Jun 19, 2023 · 1 like · 2,466 followers View post →

Phage Papers

@Phage_Papers · X

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2 https://t.co/EOs4cSPgad

Jun 17, 2023 · 647 followers View post →

Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Multivalent Bicyclic Peptides as Potent SARS-CoV-2 Inhibitors