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Front Mol Neurosci June 2023 PMID 37333619

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID.

Hussein Kadhem Al-Hakeim, Anwar Khairi Abed, Shatha Rouf Moustafa, Abbas F Almulla, Michael Maes

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Mentions

37
Peak: 22 in Jun 2023
across 3 sources since Mar 2023

Extended reach

288,341
potential audience

Total likes

62

Video views

36

Mentions per month

Mar 2023 – Oct 2025

Where it's discussed

  • X / Twitter34 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall discourse reflects a strong interest and moderate engagement with the publication, as many posts highlight the biological mechanisms like tryptophan depletion and neuroactive catabolites, using phrases such as 'critical COVID-19 is accompanied by depletion' and 'new research suggests inflammation's role.' The tone indicates recognition of the study's potential importance in illuminating Long COVID's physiological basis, contributing to a sense that the findings may have meaningful implications for future treatments.

AgreementModerate agreement

Most discussions express support or acknowledgment of the study’s findings, with some referencing the relevance of tryptophan depletion and inflammation in Long COVID symptoms.

InterestHigh interest

The discussions demonstrate high curiosity, with posts mentioning specific biological mechanisms and potential implications, indicating strong engagement with the topic.

EngagementModerate engagement

Users reference various aspects of the research, including the biochemical processes involved, emphasizing a moderate depth of discussion, though some posts are mostly summarizing rather than critically analyzing.

ImpactModerate impact

There is a perception that the research could significantly influence understanding of Long COVID and related conditions, as some posts highlight the importance of the findings for future treatment strategies.

Abstract in brief

  • Critical COVID-19 is linked to low plasma tryptophan (TRY) and an increase in neuroactive tryptophan catabolites (TRYCATs), particularly kynurenine (KYN), which have not been thoroughly investigated in Long COVID symptoms.
  • In a study of 90 Long COVID patients, researchers identified a subset (22%) with severe symptoms, characterized by low TRY levels, high KYN, and correlations with inflammation markers like C-reactive protein (CRP).
  • The findings suggest that both physiosomatic and affective symptoms in Long COVID are connected and can be influenced by inflammatory responses from the acute infection, highlighting the roles of CRP, KYN/TRY ratio, and insulin resistance
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Top posts

Most liked on X and Bluesky
Francisco Mera Cordero
@mera_cordero · X

https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrome de fatiga crónica en #longcovid #covidpersistente https://t.co/r34sR2w8Cl

Jun 19, 2023 · 41 likes · 16 shares · 6,189 followers View post →
Rene Sugar
@renesugar · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in #longCOVID #MECFS https://t.co/q5zpuT08jn

Jun 24, 2023 · 10 likes · 1 share · 3,974 followers View post →
Outbreak Updates
@outbreakupdates · X

May 16, 2023 · 5 likes · 1 share · 100,624 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in Long COVID : endophenotypic class of severe Long COVID (22% of patients) with very low TRY & (SpO2, during acute infection), https://t.co/ddGH4IaVTY

Mar 16, 2023 · 2 likes · 34,721 followers View post →
COVID-19_arXiv
@COVID19arXiv · X

Mar 16, 2023 · 1 like · 1 share · 4,512 followers View post →
Rene Sugar
@renesugar · X

https://t.co/q5zpuT08jn "Critical #COVID19 disease is accompanied by depletion of plasma tryptophan (TRY) and increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive tryptophan catabolites (TRYCATs), including kynurenine (KYN)."

Jun 24, 2023 · 1 like · 1 share · 3,974 followers View post →

All mentions

Eileen Neher
@EileenNeher · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID ⁦⁦@NeBirgitta⁩ ⁦@C_Scheibenbogen⁩ https://t.co/6eN3S0FzQh

Oct 23, 2025 · 76 followers View post →
Birgitta Neher
@NeBirgitta · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID https://t.co/GIUrMOb9rO

Nov 15, 2023 · 1 like · 2,811 followers View post →
Husseinalhakeim
@Husseinalhakeim · X

RT @COVID19arXiv:

Nov 9, 2023 · 1 share · 582 followers View post →
Husseinalhakeim
@Husseinalhakeim · X

RT @renesugar: https://t.co/q5zpuT08jn "Critical #COVID19 disease is accompanied by depletion of plasma tryptophan (TRY) and increases in…

Nov 9, 2023 · 1 share · 582 followers View post →
Robert Olney
@boretrol · X

RT @renesugar: Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective sympt…

Jun 24, 2023 · 1 share · 1,685 followers View post →
Rene Sugar
@renesugar · X

https://t.co/q5zpuT08jn "Critical #COVID19 disease is accompanied by depletion of plasma tryptophan (TRY) and increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive tryptophan catabolites (TRYCATs), including kynurenine (KYN)."

Jun 24, 2023 · 1 like · 1 share · 3,974 followers View post →
Rene Sugar
@renesugar · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in #longCOVID #MECFS https://t.co/q5zpuT08jn

Jun 24, 2023 · 10 likes · 1 share · 3,974 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

New Research: Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID: Critical COVID-19 disease is accompanied by depletion of plasma… #Molecular #Neuroscience https://t.co/1E78xgECkh

Jun 23, 2023 · 1 share · 81,066 followers View post →
Bristol FME United
@BristolFME · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective ... https://t.co/RkLfYootIT

Jun 23, 2023 · 361 followers View post →
Alvaro Osorio
@Alvar70 · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 21, 2023 · 16 shares · 140 followers View post →
jomincp
@jomincp · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 21, 2023 · 16 shares · 11 followers View post →
Asun Saldana
@AsunLapera · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 20, 2023 · 16 shares · 380 followers View post →
Leyda Sindoni
@LeydaSindoni · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 20, 2023 · 16 shares · 103 followers View post →
Real Academia de Medicina y Cirugía de Valladolid
@RealCirugia · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 20, 2023 · 16 shares · 914 followers View post →
Ros.M.
@RosM14646297 · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 20, 2023 · 16 shares · 305 followers View post →
Leyre_G.
@leyre_gp · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 20, 2023 · 16 shares · 1,053 followers View post →
Francis Estevia
@FrancisEstevia · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 19, 2023 · 16 shares · 426 followers View post →
LONG COVID Puerto Rico
@PRicoLongCovid · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 19, 2023 · 16 shares · 573 followers View post →
Dr Mario HMG
@mgmglobal · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 19, 2023 · 16 shares · 2,523 followers View post →
Alberto Román
@alberto_roman83 · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 19, 2023 · 16 shares · 2,482 followers View post →
AIREyVIDA aquí no contamos casos, los prevenimos
@AIREyVIDA2021 · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 19, 2023 · 16 shares · 1,732 followers View post →
FIBRO PROTESTA YA por tus derechos .
@BotHarmonie · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 19, 2023 · 16 shares · 3,554 followers View post →
Ana Calber
@amcalber · X

RT @mera_cordero: https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrom…

Jun 19, 2023 · 16 shares · 2,271 followers View post →
Francisco Mera Cordero
@mera_cordero · X

https://t.co/wFdzMuOCCm Catabolitos de triptófano, inflamación y resistencia a la insulina como determinantes del síndrome de fatiga crónica en #longcovid #covidpersistente https://t.co/r34sR2w8Cl

Jun 19, 2023 · 41 likes · 16 shares · 6,189 followers View post →
LongCovid
@LongCovid8 · X

En conclusión, el fenómeno fisio-afectivo del Long COVID es una manifestación de las respuestas inflamatorias durante la COVID aguda #LongCovid #CovidPersistente https://t.co/Q1D0Opsu08

Jun 19, 2023 · 458 followers View post →
LongCovidPapers
@LongCovidPapers · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID #LongCovid #pwLC https://t.co/nQksDHmZ78

Jun 19, 2023 · 2,142 followers View post →
Sally Fereday CFIRM
@SallyFereday · X

RT @outbreakupdates:

May 18, 2023 · 1 share · 6,421 followers View post →
Outbreak Updates
@outbreakupdates · X

May 16, 2023 · 5 likes · 1 share · 100,624 followers View post →
Outbreak Science
@outbreaksci · X

New preprint: Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in Long COVID https://t.co/LmgDdsL7cq #COVID19

Mar 20, 2023 · 1,373 followers View post →
More trees is always the answer
@Nancyjayneem · X

RT @LongCovidPapers: Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective…

Mar 16, 2023 · 1 share · 180 followers View post →
COVID-19_arXiv
@COVID19arXiv · X

Mar 16, 2023 · 1 like · 1 share · 4,512 followers View post →
LongCovidPapers
@LongCovidPapers · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in Long COVID https://t.co/Y3VgFqAUN7

Mar 16, 2023 · 1 like · 1 share · 2,142 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in Long COVID : endophenotypic class of severe Long COVID (22% of patients) with very low TRY & (SpO2, during acute infection), https://t.co/ddGH4IaVTY

Mar 16, 2023 · 2 likes · 34,721 followers View post →
medRxiv
@medrxivpreprint · X

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in Long COVID https://t.co/XMVrS4DNSv #medRxiv

Mar 16, 2023 · 17,463 followers View post →