Activating hidden signals by mimicking cryptic sites in a synthetic extracellular matrix.

Abstract in brief

• This study focuses on revealing and activating hidden signaling peptides within the extracellular matrix (ECM), which are normally hidden until an enzyme cleaves the ECM protein, exposing them to influence cell behavior.
• Researchers designed synthetic hydrogels that mimic this natural process, using depsipeptides that change their structure when triggered by enzymes like trypsin, forming bioactive peptides such as YIGSR that can promote cell adhesion.
• The engineered hydrogels respond to cell enzymes like aminopeptidase N, transforming from inert to adhesive, supporting cell growth, and creating a dynamic, interactive environment similar to natural tissue, which could be useful for regenerative medicine and tissue engineering.]