Nat Commun June 2023 PMID 37339949

Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence.

Guilhem Royer, Olivier Clermont, Julie Marin, Bénédicte Condamine, Sara Dion, François Blanquart, Marco Galardini, Erick Denamur

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Peak: 12 in Jun 2023

across 2 sources since Jun 2023

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Jun 2023 – Sep 2023

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The discussions consistently highlight the importance of epistatic interactions between the high pathogenicity island and iron uptake systems, with phrases like 'shape E. coli virulence' and 'understanding genetic interactions' conveying their relevance. The tone is generally positive and analytical, showing moderate engagement through sharing of summaries and author tags, indicating recognition of the study’s potential impact in microbiology and disease research.

AgreementStrong agreement

Most discussions clearly support the significance of the findings, emphasizing the importance of gene interactions in bacterial virulence.

InterestModerate interest

The posts show a moderate level of interest, mainly focusing on the novelty of epistatic interactions in E. coli research.

EngagementModerate engagement

Participants engage by sharing summaries, tagging authors, and highlighting specific aspects of the study, though most responses are brief.

ImpactModerate impact

The repeated emphasis on the research's relevance suggests a perception that it could influence future investigations or clinical approaches.

Abstract in brief

The study finds that the virulence of extraintestinal E. coli, especially in strain complex STc58, is linked to the presence of specific genes like the high-pathogenicity island (HPI) and iron uptake systems, which work together in a way that depends on the bacteria's genetic background.
Researchers discovered that the full virulence phenotype in E. coli is associated with the co-occurrence of the HPI and other iron acquisition operons (aer and sit), and this association varies depending on the strain's lineage, suggesting strong gene interactions (epistasis).
The findings highlight that the combination of virulence genes isn't random but is shaped by the bacteria's genetics, which influences how these bacteria evolve toward increased virulence, especially through specific gene interactions across different strains.

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Epistatic Interactions in Escherichia coli Virulence Mechanisms.

The study finds that the virulence of extraintestinal E. coli, especially in strain complex STc58, is linked to specific genes like the high-pathogenicity island and iron uptake systems, which interact based on the…

STEM RTCL TV · Sep 22, 2023 35 views

D'Ombre et de Lumière

@louvetou · X

RT @IAME_Center: #papersofthemonth @NatureComms : Epistatic interactions between the high #pathogenicityIsland and other #iron uptake sys…

Jun 26, 2023 · 1 share · 132 followers View post →

IAME Research Center

@IAME_Center · X

Jun 26, 2023 · 5 likes · 1 share · 539 followers View post →

Ramakrishnan

@SRamakrishnan_1 · X

RT @hlcao: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestin…

Jun 26, 2023 · 5 shares · 155 followers View post →

Saubashya Sur, PhD

@SaubashyaSur · X

RT @hlcao: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestin…

Jun 25, 2023 · 5 shares · 768 followers View post →

Sandeep J Joseph

@jose_sandeep · X

RT @hlcao: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestin…

Jun 24, 2023 · 5 shares · 204 followers View post →

Koji Yahara

@KojiYahara · X

RT @hlcao: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestin…

Jun 24, 2023 · 5 shares · 295 followers View post →

Huiluo Cao 曹慧荦

@hlcao · X

Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence | Nature Communications https://t.co/lr0KPFAaJp

Jun 24, 2023 · 4 likes · 5 shares · 2,827 followers View post →

Akosiererem

@sokaribo · X

RT @EvolvedBiofilm: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra…

Jun 23, 2023 · 4 shares · 70 followers View post →

Vivek Mutalik

@vivek_mutalik · X

RT @EvolvedBiofilm: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra…

Jun 23, 2023 · 4 shares · 5,175 followers View post →

Ilana Kolodkin-Gal

@IBiofilms · X

RT @EvolvedBiofilm: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra…

Jun 23, 2023 · 4 shares · 548 followers View post →

Lars Barquist

@LBarquist · X

RT @EvolvedBiofilm: Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra…

Jun 23, 2023 · 4 shares · 1,011 followers View post →

Akos T. Kovacs

@EvolvedBiofilm · X

Jun 23, 2023 · 16 likes · 4 shares · 21,035 followers View post →

Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence.

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Epistatic Interactions in Escherichia coli Virulence Mechanisms.