J Transl Med June 2023 PMID 37344841

Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing.

Yu Hua, Yue Zheng, Yiran Yao, Renbing Jia, Shengfang Ge, Ai Zhuang

Mentions

61
Peak: 43 in Jun 2023
across 4 sources since Jun 2023

Extended reach

487,938
potential audience

Total likes

6,412

Video views

230,523

Mentions per month

Jun 2023 – Oct 2025

Where it's discussed

  • X / Twitter50 posts
  • YouTube5 videos
  • News4 articles
  • Facebook2 posts

AI synopsis

What people are saying

Discussions emphasize the promising role of metformin as an anti-cancer agent, with posts mentioning its effectiveness and potential for therapeutic repurposing, using phrases like 'shedding new lights' and 'potential anti-cancer activity.' The tone shows enthusiasm for its future applications and recognition of the study's importance, indicating high overall agreement and interest, with some detailed engagement on mechanisms and study implications.

AgreementStrong agreement

Most comments support the idea that metformin has potential anti-cancer properties, reflecting strong consensus.

InterestHigh interest

Discussions highlight curiosity and enthusiasm about the drug's repurposing, showing high engagement and curiosity.

EngagementModerate engagement

Participants reference multiple studies and mechanisms, indicating active involvement in understanding the research.

ImpactHigh impact

Several posts suggest that the research could significantly influence future treatments and scientific understanding.

Abstract in brief

  • Metformin, a widely used antidiabetic drug, shows promise as an anticancer agent due to its safety, low cost, and ability to reduce cancer risk and mortality, though its precise mechanisms are not fully understood.
  • Its antitumor effects are thought to involve changes in energy metabolism, occurring through two main pathways: direct effects on cancer cells independent of blood glucose and insulin, and indirect effects driven by systemic metabolic changes related to blood glucose and insulin levels.
  • The review discusses how metformin's mechanisms relate to the hallmarks of cancer, exploring its potential for repurposing as a cancer therapeutic and highlighting areas for future research.

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0ViD

Jun 24, 2023 · 70 likes · 15 shares · 41,579 followers View post →
htw
@heniek_htw · X

#Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 53 likes · 16 shares · 11,282 followers View post →
Dr. Ilin Gilberto de la Torre M.
@IlindelatorreMD · X

Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IHoVGPKM87 https://t.co/P3OH4yjVpL

Jun 25, 2023 · 29 likes · 15 shares · 45,832 followers View post →
BadenerFreigeist⚔️ (formerly known as SAW-BW
@BadFreigeist · X

@sunshine31769 Leider ja Und bei starkem Übergewicht und

Dec 17, 2024 · 29 likes · 17,417 followers View post →
Reiner 
@erlesen · X

Metformin is one of the most commonly prescribed anti-diabetic drugs worldwide. Its history can be traced back to 1918 when guanidine, found in traditional herbal medicine in Europe known as Galega officinalis, was shown to lower glycemia https://t.co/ad60pp2SJ6 cancer hallmarks

Jun 23, 2023 · 4 likes · 1 share · 7,858 followers View post →
BMC
@BioMedCentral · X

A Review in the Journal of Translational Medicine discusses the possible molecular mechanisms of metformin in cancer prevention and treatment, its role in terms of cancer hallmarks, current challenges, and future directions in clinical translation. https://t.co/vD7jPMiC8P

Jun 27, 2023 · 1 like · 1 share · 75,412 followers View post →

All mentions

Walter dos Santos Jr
@WalterSantosJr2 · X

https://t.co/owGxtPxURW PRECAME Study: Preventing cardiovascular effects with metformin in obese patients ( Corpori Sano Biotechnology & Walter LAB, Brazil

Jun 21, 2025 · 51 followers View post →
Walter dos Santos Jr
@WalterSantosJr2 · X

https://t.co/owGxtPxURW PRECAME Study: Preventing cardiovascular effects with metformin in obese patients ( Corpori Sano Biotechnology & @a

Jun 21, 2025 · 51 followers View post →
BadenerFreigeist⚔️ (formerly known as SAW-BW
@BadFreigeist · X

@sunshine31769 Leider ja Und bei starkem Übergewicht und

Dec 17, 2024 · 29 likes · 17,417 followers View post →
Samir Agrawal
@Samir_Agrawal1 · X

@graham74GC Similar story for Metformin - evidence of reduced cancer risk and potential anti-cancer activity https://t.co/DbhfV2ulaD.

Dec 12, 2023 · 1 like · 184 followers View post →
Corpori Sano Biotechnology
@corporisanoclin · X

https://t.co/P3wTRffeTx. PRECAME Study: Preventing cardiovascular effects with metformin in obese patients ( Corpori Sano Biotechnology, Brasil

Dec 6, 2023 · 114 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

“Epidemiological evidence reveals that metformin reduces the risk of CANCER and decreases cancer-related mortality in patients with diabetes” @ Translational Medicine #cancer #metformin #diabetes

Jul 16, 2023 · 694 followers View post →
Fred Dennis
@LongevityMD · X

#Longevity & #Healthspan Update on Metformin-It really seems to be an anti-cancer drug https://t.co/RkcZ5j6WQq

Jul 3, 2023 · 267 followers View post →
Karla SIB
@karlasib · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 29, 2023 · 15 shares · 52 followers View post →
Jose Hernandez
@Pharma_Mty · X

RT @BioMedCentral: A Review in the Journal of Translational Medicine discusses the possible molecular mechanisms of metformin in cancer pre…

Jun 27, 2023 · 1 share · 194 followers View post →
BMC
@BioMedCentral · X

A Review in the Journal of Translational Medicine discusses the possible molecular mechanisms of metformin in cancer prevention and treatment, its role in terms of cancer hallmarks, current challenges, and future directions in clinical translation. https://t.co/vD7jPMiC8P

Jun 27, 2023 · 1 like · 1 share · 75,412 followers View post →
Iammaesie
@Iammaesie · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 26, 2023 · 15 shares · 109 followers View post →
Roman Samoilenko
@nilsbored · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 42 followers View post →
Varna
@Varna00517297 · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 172 followers View post →
Vicente Lozada-Balderrama
@VicenteLozadaB · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 13,630 followers View post →
manishikuma/манішікума
@manishikuma · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 349 followers View post →
Gabino Loor
@GabinoLoor · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 141 followers View post →
pelusa
@peluswain · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 1,598 followers View post →
Omed
@Omedina311 · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 815 followers View post →
hscott61
@hscott61 · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 755 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 3,168 followers View post →
Lilia Andrea
@LiliaAndreataf1 · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 379 followers View post →
Dr. Salvatore05
@Eliasreinaldi5 · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 532 followers View post →
Octavio Rivera M.D.
@OctavioRivera_ · X

RT @IlindelatorreMD: Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IH…

Jun 25, 2023 · 15 shares · 249 followers View post →
Dr. Ilin Gilberto de la Torre M.
@IlindelatorreMD · X

Metformina y características del cáncer : arrojando nuevas luces sobre la reutilización terapéutica. https://t.co/IHoVGPKM87 https://t.co/P3OH4yjVpL

Jun 25, 2023 · 29 likes · 15 shares · 45,832 followers View post →
Zen⚡️Chu ⛑
@accelmed · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 3,109 followers View post →
Seda
@sedaciftci · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 140 followers View post →
aesthebi
@103_Takashi · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 1,793 followers View post →
Lisa Vlad
@LisaVlad2 · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 106 followers View post →
Sadeeq Sheshe
@ShesheSadeeq · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 886 followers View post →
Najme Dehghanbanadaki
@Dbanadaki · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 49 followers View post →
John Greene
@Greene_Thoughts · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 1,683 followers View post →
Andrés Grases
@agrases · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 520 followers View post →
Marco Antonio Galván
@Marco_A_Galvan · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 968 followers View post →
SANTHOSH KUMAR VANGALA
@santhoshmpharm2 · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 25, 2023 · 15 shares · 81 followers View post →
TheOneToWatch
@TruthWrestler44 · X

RT @agingdoc1: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0…

Jun 24, 2023 · 15 shares · 147 followers View post →
Agingdoc
@agingdoc1 · X

Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing https://t.co/6TzEXGD7IG https://t.co/5l5obS0ViD

Jun 24, 2023 · 70 likes · 15 shares · 41,579 followers View post →
Reiner 
@erlesen · X

RT @erlesen: Metformin is one of the most commonly prescribed anti-diabetic drugs worldwide. Its history can be traced back to 1918 when gu…

Jun 24, 2023 · 1 share · 7,858 followers View post →
Michelle Mc
@Michell96839440 · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 23, 2023 · 16 shares · 120 followers View post →
Reiner 
@erlesen · X

Metformin is one of the most commonly prescribed anti-diabetic drugs worldwide. Its history can be traced back to 1918 when guanidine, found in traditional herbal medicine in Europe known as Galega officinalis, was shown to lower glycemia https://t.co/ad60pp2SJ6 cancer hallmarks

Jun 23, 2023 · 4 likes · 1 share · 7,858 followers View post →
Ronita De, PhD
@dronita_de · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 23, 2023 · 16 shares · 1,499 followers View post →
Timberman
@avirvr9 · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 196 followers View post →
Jorge Rosas
@guruesmx · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 135 followers View post →
Tetekindeeeeeh
@BDhaure · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 630 followers View post →
Jose Hernandez
@Pharma_Mty · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 194 followers View post →
つとむ
@tsutomuinfinity · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 192 followers View post →
Bayar Jaff
@JaffBayar · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 607 followers View post →
htw
@heniek_htw · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 11,282 followers View post →
Javed Alam
@jalam1001 · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 995 followers View post →
NAD+
@madnadfit · X

RT @heniek_htw: #Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 16 shares · 99 followers View post →
htw
@heniek_htw · X

#Metformin and #cancer hallmarks: shedding new lights on therapeutic repurposing

Jun 22, 2023 · 53 likes · 16 shares · 11,282 followers View post →